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dc.creatorLukić, Vera
dc.creatorMicić, Ružica
dc.creatorArsić, Biljana
dc.creatorMitić, Milan
dc.creatorJovanović, Miloš
dc.creatorPavlović, Aleksandra
dc.date.accessioned2022-02-03T09:06:08Z
dc.date.available2022-02-03T09:06:08Z
dc.date.issued2021
dc.identifier.issn2391-5420
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/4050
dc.description.abstractThe samples of plant material suspected to contain new psychoactive substances are very often the subject of chemical-toxicological analyses. Gas chromatography-mass spectrometry (MS), liquid chromatography-quadrupole time-of-flight-MS, and liquid chromatography-tandem MS were applied with the aim to identify synthetic cannabinoid, methyl 2-{[1-(cyclohexylmethyl)-1H-indol-3-yl] formamido}-3-methylbutanoate (MMB-CHMICA) without the analytical standard, which is very often the case when a new drug arrives. The structure of compound was also confirmed by one-dimensional and two-dimensional nuclear magnetic resonance spectroscopy and conformational analysis. After identification, methanolic extract of plant material containing MMB-CHMICA was successfully used for developing a multiple reaction monitoring method on liquid chromatography-tandem MS instrument. The optimization procedure is shown in detail. The complete fragmentation pattern and also the optimization of the extraction procedure of MMB-CHMICA from plant material were shown. The obtained data are useful for forensic, toxicological, and clinical purposes.
dc.publisherDe Gruyter Open Ltd
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200123/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceOpen Chemistry
dc.subjecthigh-resolution mass spectrometry
dc.subjectidentification of NPS
dc.subjectMMB-CHMICA
dc.subjectMRM optimization
dc.subjectsynthetic cannabinoids
dc.titleIdentification of synthetic cannabinoid methyl 2-{[1-(cyclohexylmethyl)-1H-indol-3-yl] formamido}-3-methylbutanoate using modern mass spectrometry and nuclear magnetic resonance techniques
dc.typearticle
dc.rights.licenseBY
dc.citation.volume19
dc.citation.issue1
dc.citation.spage1259
dc.citation.epage1273
dc.citation.rankM23
dc.identifier.wos000736839200001
dc.identifier.doi10.1515/chem-2021-0113
dc.identifier.scopus2-s2.0-85123318672
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/9502/Identification_of_synthetic_pub_2021.pdf
dc.type.versionpublishedVersion


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Приказ основних података о документу