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dc.creatorŽivančević, Katarina
dc.creatorBaralić, Katarina
dc.creatorBožić, Dragica
dc.creatorAntonijević-Miljaković, Evica
dc.creatorBuha-Đorđević, Aleksandra
dc.creatorĆurčić, Marijana
dc.creatorBulat, Zorica
dc.creatorAntonijević, Biljana
dc.creatorBulat, Petar
dc.creatorĐukić-Ćosić, Danijela
dc.date.accessioned2022-02-09T09:11:48Z
dc.date.available2022-02-09T09:11:48Z
dc.date.issued2022
dc.identifier.issn0278-6915
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/4052
dc.description.abstractWe aimed to examine the molecular basis of the positive effect of berberine against environmentally relevant toxic metal-linked Alzheimer’s disease (AD). The Comparative Toxicogenomic Database (CTD) retrieved a set of genes common to lead, cadmium, methylmercury and arsenic linked to AD development and a set of genes through which berberine exerts a therapeutic mode of action in AD. GeneMania prediction server revealed detailed gene interactions, while Metascape highlighted protein-protein interaction enrichment (PPIE). SwissADME evaluated physicochemical properties of berberine. Berberine had an antagonistic effect for the majority of genes mutual for AD and toxic metal mixture: ACHE, APP, BAX, BCL2, CASP3, HMOX1, IL1B, MAPT, SOD2, TNF. Gene network analysis revealed interactions predicted by the server (45.29%) and physical interactions (18.39%) as the most important. Enriched biological processes analysis showed apoptotic signaling pathway, positive regulation of organelle organization and response to oxidative stress as dominant pathways involved in berberine protective effects against toxic metal mixture, while PPIE analysis showed regulation of apoptotic signaling pathway as the main gene ontology process targeted by berberine. Physicochemical properties and pharmacokinetics of berberine are in concordance with its beneficial properties in AD due to the high gastrointestinal absorption and capability to pass the blood-brain barrier.
dc.publisherElsevier Ltd
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//
dc.rightsrestrictedAccess
dc.sourceFood and Chemical Toxicology
dc.subjectToxicogenomic data mining
dc.subjectAlzheimer's diesase
dc.subjectBerberine
dc.subjectEnvironmentally relevant toxic metal mixture
dc.subjectMolecular mechanisms
dc.titleInvolvement of environmentally relevant toxic metal mixture in Alzheimer's disease pathway alteration and protective role of berberine: Bioinformatics analysis and toxicogenomic screening
dc.typearticle
dc.rights.licenseARR
dc.citation.volume161
dc.citation.rankaM21
dc.identifier.wos000750832500001
dc.identifier.doi10.1016/j.fct.2022.112839
dc.identifier.scopus2-s2.0-85123701707
dc.type.versionpublishedVersion


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