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dc.creatorAaseth, Jan
dc.creatorJavorac, Dragana
dc.creatorBuha-Đorđević, Aleksandra
dc.creatorBulat, Zorica
dc.creatorSkalny, Anatoly
dc.creatorZaitseva, Irina
dc.creatorAschner, Michael
dc.creatorTinkov, Alexey
dc.date.accessioned2022-03-01T14:26:28Z
dc.date.available2022-03-01T14:26:28Z
dc.date.issued2022
dc.identifier.issn2305-6304
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/4059
dc.description.abstractPersistent organic pollutants (POPs) are considered as potential obesogens that may affect adipose tissue development and functioning, thus promoting obesity. However, various POPs may have different mechanisms of action. The objective of the present review is to discuss the key mechanisms linking exposure to POPs to adipose tissue dysfunction and obesity. Laboratory data clearly demonstrate that the mechanisms associated with the interference of exposure to POPs with obesity include: (a) dysregulation of adipogenesis regulators (PPAR and C/EBP); (b) affinity and binding to nuclear receptors; (c) epigenetic effects; and/or (d) proinflammatory activity. Although in vivo data are generally corroborative of the in vitro results, studies in living organisms have shown that the impact of POPs on adipogenesis is affected by biological factors such as sex, age, and period of exposure. Epidemiological data demonstrate a significant association between exposure to POPs and obesity and obesity-associated metabolic disturbances (e.g., type 2 diabetes mellitus and metabolic syndrome), although the existing data are considered insufficient. In conclusion, both laboratory and epidemiological data underline the significant role of POPs as environmental obesogens. However, further studies are required to better characterize both the mechanisms and the dose/concentration-response effects of exposure to POPs in the development of obesity and other metabolic diseases.
dc.publisherMDPI
dc.relationThe study was supported by the Ministry of Science and Higher Education of the Russian Federation within the framework of state support for the creation and development ofWorld-Class Research Centers “Digital biodesign and personalized healthcare” 075-15-2020-926.
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceToxics
dc.subjectObesity
dc.subjectBisphenol A
dc.subjectPhthalates
dc.subjectAdipogenesis
dc.subjectDichlorodiphenyltrichloroethane
dc.subjectDioxin
dc.subjectPerfluorinated compounds
dc.subjectPolyaromatic hydrocarbons
dc.subjectPolybromated diphenylethers
dc.subjectPolychlorinated biphenyls
dc.titleThe Role of Persistent Organic Pollutants in Obesity: A Review of Laboratory and Epidemiological Studies
dc.typearticle
dc.rights.licenseBY
dc.citation.volume10
dc.citation.issue2
dc.citation.rankM21
dc.identifier.wos000762075300001
dc.identifier.doi10.3390/toxics10020065
dc.identifier.scopus2-s2.0-85124991373
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/9529/The_Role_of_pub_2022.pdf
dc.type.versionpublishedVersion


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