Приказ основних података о документу

dc.creatorRadojević, Branislava
dc.creatorDragašević-Mišković, Nataša
dc.creatorMarjanović, Ana
dc.creatorBranković, Marija
dc.creatorMilovanović, Andona
dc.creatorPetrović, Igor
dc.creatorSvetel, Marina
dc.creatorJančić, Ivan
dc.creatorStanisavljević, Dejana
dc.creatorMilićević, Ognjen
dc.creatorSavić, Miroslav
dc.creatorKostić, Vladimir
dc.date.accessioned2022-04-19T08:49:02Z
dc.date.available2022-04-19T08:49:02Z
dc.date.issued2022
dc.identifier.issn1353-8020
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/4082
dc.description.abstractBackground: Clinical-related risk factors to freezing of gait (FOG) in Parkinson’s disease (PD) have been iden- tified. Still, the influence of genetic variations on the FOG occurrence has been poorly studied thus far. Aim: We aimed to evaluate the association of six selected polymorphisms of DRD2, ANKK1, and COMT genes with the FOG occurrence and explore the influence of ANNK1/DRD2 haplotypes on the onset of FOG in the group of PD patients. Method: PD patients (n = 234), treated with levodopa for at least two years, were genotyped for the rs4680 in COMT, rs6277, rs1076560, and rs2283265 in DRD2, and rs1800497 and rs2734849 polymorphisms in ANKK1 genes. FOG was evaluated by posing a direct question. In addition, a comprehensive set of clinical scales was applied to all patients. Results: FOG occurred in 132 (56.4%) PD patients in our cohort. Freezers were younger at PD onset, had longer disease duration, used higher levodopa daily doses and dopaminergic agents, and had higher motor and non- motor scales scores than non-freezers. FOG was more frequent among AA rs4680 COMT carriers than AG and GG rs4680 COMT carriers. Independent predictors of FOG were: disease duration of more than ten years, levodopa daily dose higher than 500 mg/day, motor status, and COMT AA genotype. AGGAA and GGAAA haplotypes were revealed as protective and vulnerability factors for FOG occurrence. Conclusion: In addition to previously identified disease- and therapy-related risk factors, our results suggested a possible contribution of dopamine-related genes to the FOG occurrence.
dc.publisherElsevier Ltd
dc.rightsrestrictedAccess
dc.sourceParkinsonism and Related Disorders
dc.subjectCOMT Val158Met
dc.subjectDRD2
dc.subjectFreezing of gait
dc.subjectGenetic polymorphisms
dc.subjectParkinson's disease
dc.subjectRisk factors
dc.titleThe correlation between genetic factors and freezing of gait in patients with Parkinson's disease
dc.typearticle
dc.rights.licenseARR
dc.citation.volume98
dc.citation.spage7
dc.citation.epage12
dc.citation.rankM21
dc.identifier.wos00080521720000
dc.identifier.doi10.1016/j.parkreldis.2022.03.018
dc.identifier.scopus2-s2.0-85127820869
dc.type.versionpublishedVersion


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Приказ основних података о документу