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Spasmolytic, Gastroprotective and Antioxidant Activities of Dry Methanol Extract of Ferula heuffelii Underground Parts
dc.creator | Pavlović, Ivan | |
dc.creator | Radenković, Mirjana | |
dc.creator | Branković, Suzana | |
dc.creator | Milenković, Marina | |
dc.creator | Niketić, Marjan | |
dc.creator | Ušjak, Ljuboš | |
dc.creator | Petrović, Silvana | |
dc.date.accessioned | 2022-04-19T10:04:53Z | |
dc.date.available | 2022-04-19T10:04:53Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 1612-1872 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/4084 | |
dc.description.abstract | Dry MeOH extract of Ferula heuffelii (Apiaceae) underground parts was tested for spasmolytic, gastroprotective and antioxidant activities. HPLC analysis revealed that chlorogenic acid (CGA; 34.6 mg/g) was its main constituent. Extract in vitro exhibited notable total antioxidant activity (FRAP value=1.0 μmol Fe2+/mg), and scavenging of DPPH (SC50=62.5 μg/ml) and •OH radicals (49.5 % at 20 μg/ml in 2-deoxyribose assay). In vitro on isolated rat ileum, extract exhibited significant spasmolytic activity, i. e., it showed 124.6 % of maximal atropine effect on spontaneous contractions (at 100 μg/ml), and reduced spasmogenic effect of KCl (80 mm) to 44.4 % (at 60 μg/ml) and of highest applied concentration of ACh to 26.3 % (at 120 μg/ml). In parallel experiments, spasmolytic effect of CGA was also demonstrated. In acute EtOH-induced gastric ulceration model in rats, extract (100 mg/kg p.o.) showed significant gastroprotective effect (gastric damage score 0.50), similar to ranitidine (20 mg/kg p.o.). Obtained results showed that tested F. heuffelii polar extract represents new herbal preparation with potential use against some gastrointestinal complaints. | |
dc.publisher | John Wiley and Sons Inc | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200113/RS// | |
dc.rights | restrictedAccess | |
dc.source | Chemistry and Biodiversity | |
dc.subject | antioxidants | |
dc.subject | Ferula heuffelii dry MeOH extract | |
dc.subject | gastroprotective effect | |
dc.subject | liquid chromatography | |
dc.subject | spasmolytic activity | |
dc.title | Spasmolytic, Gastroprotective and Antioxidant Activities of Dry Methanol Extract of Ferula heuffelii Underground Parts | |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.volume | 19 | |
dc.citation.issue | 5 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000781617100001 | |
dc.identifier.doi | 10.1002/cbdv.202200047 | |
dc.identifier.scopus | 2-s2.0-85127965760 | |
dc.type.version | publishedVersion |