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dc.creatorBarišić, Goran
dc.creatorAnđelkov, Katarina
dc.creatorRosić, Jovana
dc.creatorMiladinov, Marko
dc.creatorKotur-Stevuljević, Jelena
dc.creatorDinić, Tanja
dc.creatorJelenković, Jelenko
dc.creatorKrivokapić, Zoran
dc.date.accessioned2022-05-11T12:15:39Z
dc.date.available2022-05-11T12:15:39Z
dc.date.issued2022
dc.identifier.issn1462-8910
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/4092
dc.description.abstractAim: The aim of this study was to investigate whether the application of nanofat contain-ing stem cells improves continence in women who had previously undergone anal sphinc-teroplasty with unsatisfactory long-term outcomes.Method: This prospective pilot study included nine women with various degrees of anal incontinence who had previously undergone anal sphincteroplasty due to obstetric trauma. In all patients, the Wexner Incontinence Score (WS) and Faecal Incontinence Quality of Life Score (FIQLS), as well as anal manometry and endoanal ultrasound meas-urements, were performed before the procedure and during follow-up. In all patients, liposuction was performed and 50 ml of raw lipoaspirate was obtained and processed using a NanoFat Kit device. Approximately 20 ml of the mechanically emulsified and fil-trated fat was obtained and the anal sphincter complex was infiltrated with it. Patient fol-low-up was conducted in person or via telephone 6 and 12 months after the procedure.Results: The squeeze pressure was significantly increased 6 months after the proce-dure (p= 0.01). The external anal sphincter measured at the 12 o'clock position was sig-nificantly thicker (p= 0.04). A significant decrease in the WS was observed both 6 and 12 months after the procedure compared with baseline values (p< 0.05 for both).Conclusion: This study is the first to show that the application of nanofat as an inject-able product improves continence in patients with unsatisfactory results after sphinc-teroplasty, suggesting it to be a promising and effective therapeutic tool. The procedure is safe and can be easily performed as an ambulatory procedure.
dc.publisherJohn Wiley and Sons Inc
dc.rightsrestrictedAccess
dc.sourceColorectal Disease
dc.subjectadipose-derived stromal cells
dc.subjectfaecal incontinence
dc.subjectliposuction
dc.subjectnanofat
dc.subjectregenerative cell-based medicine
dc.subjectsphincteroplasty
dc.titleApplication of nanofat for treatment of traumatic faecal incontinence after sphincteroplasty – A pilot study
dc.typearticle
dc.rights.licenseARR
dc.citation.volume24
dc.citation.issue9
dc.citation.spage1054
dc.citation.epage1062
dc.citation.rankM21
dc.identifier.wos000789539400001
dc.identifier.doi10.1111/codi.16148
dc.identifier.scopus2-s2.0-85128678915
dc.type.versionpublishedVersion


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