Epigenetic mechanisms in metal carcinogenesis
Аутори
Manić, LukaWallace, David
Onganer, Pinar Uysal
Taalab, Yasmeen
Farooqi, Ammad
Antonijević, Biljana
Buha-Đorđević, Aleksandra
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Many metals exhibit genotoxic and/or carcinogenic effects. These toxic metals can be found ubiquitously – in drinking water, food, air, general use products, in everyday and occupational settings. Exposure to such carcinogenic metals can result in serious health disorders, including cancer. Arsenic, cadmium, chromium, nickel, and their compounds have already been recognized as carcinogens by the International Agency for Research on Cancer. This review summarizes a wide range of epigenetic mechanisms contributing to carcinogenesis induced by these metals, primarily including, but not limited to, DNA methylation, miRNA regulation, and histone posttranslational modifications. The mechanisms are described and discussed both from a metal-centric and a mechanism-centric standpoint. The review takes a broad perspective, putting the mechanisms in the context of real-life exposure, and aims to assist in guiding future research, particularly with respect to the assessment and control of exposure... to carcinogenic metals and novel therapy development.
Извор:
Toxicology Reports, 2022, 9, 778-787Издавач:
- Elsevier Inc.
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
Институција/група
PharmacyTY - JOUR AU - Manić, Luka AU - Wallace, David AU - Onganer, Pinar Uysal AU - Taalab, Yasmeen AU - Farooqi, Ammad AU - Antonijević, Biljana AU - Buha-Đorđević, Aleksandra PY - 2022 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4101 AB - Many metals exhibit genotoxic and/or carcinogenic effects. These toxic metals can be found ubiquitously – in drinking water, food, air, general use products, in everyday and occupational settings. Exposure to such carcinogenic metals can result in serious health disorders, including cancer. Arsenic, cadmium, chromium, nickel, and their compounds have already been recognized as carcinogens by the International Agency for Research on Cancer. This review summarizes a wide range of epigenetic mechanisms contributing to carcinogenesis induced by these metals, primarily including, but not limited to, DNA methylation, miRNA regulation, and histone posttranslational modifications. The mechanisms are described and discussed both from a metal-centric and a mechanism-centric standpoint. The review takes a broad perspective, putting the mechanisms in the context of real-life exposure, and aims to assist in guiding future research, particularly with respect to the assessment and control of exposure to carcinogenic metals and novel therapy development. PB - Elsevier Inc. T2 - Toxicology Reports T1 - Epigenetic mechanisms in metal carcinogenesis VL - 9 SP - 778 EP - 787 DO - 10.1016/j.toxrep.2022.03.037 ER -
@article{ author = "Manić, Luka and Wallace, David and Onganer, Pinar Uysal and Taalab, Yasmeen and Farooqi, Ammad and Antonijević, Biljana and Buha-Đorđević, Aleksandra", year = "2022", abstract = "Many metals exhibit genotoxic and/or carcinogenic effects. These toxic metals can be found ubiquitously – in drinking water, food, air, general use products, in everyday and occupational settings. Exposure to such carcinogenic metals can result in serious health disorders, including cancer. Arsenic, cadmium, chromium, nickel, and their compounds have already been recognized as carcinogens by the International Agency for Research on Cancer. This review summarizes a wide range of epigenetic mechanisms contributing to carcinogenesis induced by these metals, primarily including, but not limited to, DNA methylation, miRNA regulation, and histone posttranslational modifications. The mechanisms are described and discussed both from a metal-centric and a mechanism-centric standpoint. The review takes a broad perspective, putting the mechanisms in the context of real-life exposure, and aims to assist in guiding future research, particularly with respect to the assessment and control of exposure to carcinogenic metals and novel therapy development.", publisher = "Elsevier Inc.", journal = "Toxicology Reports", title = "Epigenetic mechanisms in metal carcinogenesis", volume = "9", pages = "778-787", doi = "10.1016/j.toxrep.2022.03.037" }
Manić, L., Wallace, D., Onganer, P. U., Taalab, Y., Farooqi, A., Antonijević, B.,& Buha-Đorđević, A.. (2022). Epigenetic mechanisms in metal carcinogenesis. in Toxicology Reports Elsevier Inc.., 9, 778-787. https://doi.org/10.1016/j.toxrep.2022.03.037
Manić L, Wallace D, Onganer PU, Taalab Y, Farooqi A, Antonijević B, Buha-Đorđević A. Epigenetic mechanisms in metal carcinogenesis. in Toxicology Reports. 2022;9:778-787. doi:10.1016/j.toxrep.2022.03.037 .
Manić, Luka, Wallace, David, Onganer, Pinar Uysal, Taalab, Yasmeen, Farooqi, Ammad, Antonijević, Biljana, Buha-Đorđević, Aleksandra, "Epigenetic mechanisms in metal carcinogenesis" in Toxicology Reports, 9 (2022):778-787, https://doi.org/10.1016/j.toxrep.2022.03.037 . .