Many metals exhibit genotoxic and/or carcinogenic effects. These toxic metals can be found ubiquitously – in drinking water, food, air, general use products, in everyday and occupational settings. Exposure to such carcinogenic metals can result in serious health disorders, including cancer. Arsenic, cadmium, chromium, nickel, and their compounds have already been recognized as carcinogens by the International Agency for Research on Cancer. This review summarizes a wide range of epigenetic mechanisms contributing to carcinogenesis induced by these metals, primarily including, but not limited to, DNA methylation, miRNA regulation, and histone posttranslational modifications. The mechanisms are described and discussed both from a metal-centric and a mechanism-centric standpoint. The review takes a broad perspective, putting the mechanisms in the context of real-life exposure, and aims to assist in guiding future research, particularly with respect to the assessment and control of exposure... to carcinogenic metals and novel therapy development.
TY - JOUR
AU - Manić, Luka
AU - Wallace, David
AU - Onganer, Pinar Uysal
AU - Taalab, Yasmeen
AU - Farooqi, Ammad
AU - Antonijević, Biljana
AU - Buha-Đorđević, Aleksandra
PY - 2022
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4101
AB - Many metals exhibit genotoxic and/or carcinogenic effects. These toxic metals can be found ubiquitously – in drinking water, food, air, general use products, in everyday and occupational settings. Exposure to such carcinogenic metals can result in serious health disorders, including cancer. Arsenic, cadmium, chromium, nickel, and their compounds have already been recognized as carcinogens by the International Agency for Research on Cancer. This review summarizes a wide range of epigenetic mechanisms contributing to carcinogenesis induced by these metals, primarily including, but not limited to, DNA methylation, miRNA regulation, and histone posttranslational modifications. The mechanisms are described and discussed both from a metal-centric and a mechanism-centric standpoint. The review takes a broad perspective, putting the mechanisms in the context of real-life exposure, and aims to assist in guiding future research, particularly with respect to the assessment and control of exposure to carcinogenic metals and novel therapy development.
PB - Elsevier Inc.
T2 - Toxicology Reports
T1 - Epigenetic mechanisms in metal carcinogenesis
VL - 9
SP - 778
EP - 787
DO - 10.1016/j.toxrep.2022.03.037
ER -
@article{
author = "Manić, Luka and Wallace, David and Onganer, Pinar Uysal and Taalab, Yasmeen and Farooqi, Ammad and Antonijević, Biljana and Buha-Đorđević, Aleksandra",
year = "2022",
abstract = "Many metals exhibit genotoxic and/or carcinogenic effects. These toxic metals can be found ubiquitously – in drinking water, food, air, general use products, in everyday and occupational settings. Exposure to such carcinogenic metals can result in serious health disorders, including cancer. Arsenic, cadmium, chromium, nickel, and their compounds have already been recognized as carcinogens by the International Agency for Research on Cancer. This review summarizes a wide range of epigenetic mechanisms contributing to carcinogenesis induced by these metals, primarily including, but not limited to, DNA methylation, miRNA regulation, and histone posttranslational modifications. The mechanisms are described and discussed both from a metal-centric and a mechanism-centric standpoint. The review takes a broad perspective, putting the mechanisms in the context of real-life exposure, and aims to assist in guiding future research, particularly with respect to the assessment and control of exposure to carcinogenic metals and novel therapy development.",
publisher = "Elsevier Inc.",
journal = "Toxicology Reports",
title = "Epigenetic mechanisms in metal carcinogenesis",
volume = "9",
pages = "778-787",
doi = "10.1016/j.toxrep.2022.03.037"
}
Manić, L., Wallace, D., Onganer, P. U., Taalab, Y., Farooqi, A., Antonijević, B.,& Buha-Đorđević, A.. (2022). Epigenetic mechanisms in metal carcinogenesis. in Toxicology Reports
Elsevier Inc.., 9, 778-787.
https://doi.org/10.1016/j.toxrep.2022.03.037
Manić L, Wallace D, Onganer PU, Taalab Y, Farooqi A, Antonijević B, Buha-Đorđević A. Epigenetic mechanisms in metal carcinogenesis. in Toxicology Reports. 2022;9:778-787.
doi:10.1016/j.toxrep.2022.03.037 .
Manić, Luka, Wallace, David, Onganer, Pinar Uysal, Taalab, Yasmeen, Farooqi, Ammad, Antonijević, Biljana, Buha-Đorđević, Aleksandra, "Epigenetic mechanisms in metal carcinogenesis" in Toxicology Reports, 9 (2022):778-787,
https://doi.org/10.1016/j.toxrep.2022.03.037 . .
