Possible role of lead in breast cancer — a case-control study
Authorized Users Only
2022
Authors
Anđelković, Milena
Buha-Đorđević, Aleksandra

Javorac, Dragana

Baralić, Katarina

Đukić-Ćosić, Danijela

Repić, Aleksandra
Zeljković, Aleksandra

Vekić, Jelena

Čolaković, Nataša
Bulat, Zorica

Article (Published version)

Metadata
Show full item recordAbstract
Numerous risk factors have been associated with breast cancer (BC), exposure to metalloestrogen, like lead, being such. Since lead involvement in BC is still equivocal, we focused on lead levels in three compartments of BC patients, blood, healthy, and malignant tissues. Also, as the cholesterol role in cancer development was recognized at the beginning of the twentieth century and led to involvement in lipid profile impairment, we further extend our research on lipid profile and enzymes responsible for maintaining lipid balance in BC patients. Fifty-five women diagnosed with BC were enrolled in the study. Forty-one healthy women represented the control group. Lead levels in blood, healthy surrounding and malignant tissue, and lipid profile parameters in serum, were determined. Higher lead levels were obtained in surrounding healthy tissue samples compared to cancerous tissue samples, while blood lead levels of BC women did not differ significantly from the control group. The altered l...ipid profile scheme in women diagnosed with breast cancer contained significantly higher triglycerides levels (P < 0.001). Moreover, logistic regression analysis revealed triglycerides as a significant predictor of BC (OR = 2.6; P < 0.01). Although statistical significance was missing for lower paraoxonase-1 (PON-1) activities observed in BC women, multivariate logistic regression singled out PON-1 activities as significant BC predictors. The result of the present study further indicated oxidative status imbalance and tissue levels bioelements perturbation. Obtained results in the present study propose possible lead involvement in BC onset accompanied with bioelements redistribution and oxidative stress occurrence.
Keywords:
Breast cancer / Lead / CETP / LCAT / Lipid profile / Oxidative stressSource:
Environmental Science and Pollution Research, 2022, 29, 65211-65221Publisher:
- Springer Nature
Funding / projects:
DOI: 10.1007/s11356-022-20439-z
ISSN: 0944-1344
WoS: 000788985600012
Scopus: 2-s2.0-85129101066
Collections
Institution/Community
PharmacyTY - JOUR AU - Anđelković, Milena AU - Buha-Đorđević, Aleksandra AU - Javorac, Dragana AU - Baralić, Katarina AU - Đukić-Ćosić, Danijela AU - Repić, Aleksandra AU - Zeljković, Aleksandra AU - Vekić, Jelena AU - Čolaković, Nataša AU - Bulat, Zorica PY - 2022 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4103 AB - Numerous risk factors have been associated with breast cancer (BC), exposure to metalloestrogen, like lead, being such. Since lead involvement in BC is still equivocal, we focused on lead levels in three compartments of BC patients, blood, healthy, and malignant tissues. Also, as the cholesterol role in cancer development was recognized at the beginning of the twentieth century and led to involvement in lipid profile impairment, we further extend our research on lipid profile and enzymes responsible for maintaining lipid balance in BC patients. Fifty-five women diagnosed with BC were enrolled in the study. Forty-one healthy women represented the control group. Lead levels in blood, healthy surrounding and malignant tissue, and lipid profile parameters in serum, were determined. Higher lead levels were obtained in surrounding healthy tissue samples compared to cancerous tissue samples, while blood lead levels of BC women did not differ significantly from the control group. The altered lipid profile scheme in women diagnosed with breast cancer contained significantly higher triglycerides levels (P < 0.001). Moreover, logistic regression analysis revealed triglycerides as a significant predictor of BC (OR = 2.6; P < 0.01). Although statistical significance was missing for lower paraoxonase-1 (PON-1) activities observed in BC women, multivariate logistic regression singled out PON-1 activities as significant BC predictors. The result of the present study further indicated oxidative status imbalance and tissue levels bioelements perturbation. Obtained results in the present study propose possible lead involvement in BC onset accompanied with bioelements redistribution and oxidative stress occurrence. PB - Springer Nature T2 - Environmental Science and Pollution Research T1 - Possible role of lead in breast cancer — a case-control study VL - 29 SP - 65211 EP - 65221 DO - 10.1007/s11356-022-20439-z ER -
@article{ author = "Anđelković, Milena and Buha-Đorđević, Aleksandra and Javorac, Dragana and Baralić, Katarina and Đukić-Ćosić, Danijela and Repić, Aleksandra and Zeljković, Aleksandra and Vekić, Jelena and Čolaković, Nataša and Bulat, Zorica", year = "2022", abstract = "Numerous risk factors have been associated with breast cancer (BC), exposure to metalloestrogen, like lead, being such. Since lead involvement in BC is still equivocal, we focused on lead levels in three compartments of BC patients, blood, healthy, and malignant tissues. Also, as the cholesterol role in cancer development was recognized at the beginning of the twentieth century and led to involvement in lipid profile impairment, we further extend our research on lipid profile and enzymes responsible for maintaining lipid balance in BC patients. Fifty-five women diagnosed with BC were enrolled in the study. Forty-one healthy women represented the control group. Lead levels in blood, healthy surrounding and malignant tissue, and lipid profile parameters in serum, were determined. Higher lead levels were obtained in surrounding healthy tissue samples compared to cancerous tissue samples, while blood lead levels of BC women did not differ significantly from the control group. The altered lipid profile scheme in women diagnosed with breast cancer contained significantly higher triglycerides levels (P < 0.001). Moreover, logistic regression analysis revealed triglycerides as a significant predictor of BC (OR = 2.6; P < 0.01). Although statistical significance was missing for lower paraoxonase-1 (PON-1) activities observed in BC women, multivariate logistic regression singled out PON-1 activities as significant BC predictors. The result of the present study further indicated oxidative status imbalance and tissue levels bioelements perturbation. Obtained results in the present study propose possible lead involvement in BC onset accompanied with bioelements redistribution and oxidative stress occurrence.", publisher = "Springer Nature", journal = "Environmental Science and Pollution Research", title = "Possible role of lead in breast cancer — a case-control study", volume = "29", pages = "65211-65221", doi = "10.1007/s11356-022-20439-z" }
Anđelković, M., Buha-Đorđević, A., Javorac, D., Baralić, K., Đukić-Ćosić, D., Repić, A., Zeljković, A., Vekić, J., Čolaković, N.,& Bulat, Z.. (2022). Possible role of lead in breast cancer — a case-control study. in Environmental Science and Pollution Research Springer Nature., 29, 65211-65221. https://doi.org/10.1007/s11356-022-20439-z
Anđelković M, Buha-Đorđević A, Javorac D, Baralić K, Đukić-Ćosić D, Repić A, Zeljković A, Vekić J, Čolaković N, Bulat Z. Possible role of lead in breast cancer — a case-control study. in Environmental Science and Pollution Research. 2022;29:65211-65221. doi:10.1007/s11356-022-20439-z .
Anđelković, Milena, Buha-Đorđević, Aleksandra, Javorac, Dragana, Baralić, Katarina, Đukić-Ćosić, Danijela, Repić, Aleksandra, Zeljković, Aleksandra, Vekić, Jelena, Čolaković, Nataša, Bulat, Zorica, "Possible role of lead in breast cancer — a case-control study" in Environmental Science and Pollution Research, 29 (2022):65211-65221, https://doi.org/10.1007/s11356-022-20439-z . .