Maprotiline, desipramine and moclobemide are widely used in the treatment of depression. The content of these antidepressants in bulk drug and pharmaceutical formulations were determined by TLC and in situ densitometry using a Camag scanner In order to achieve the best condition, mathematical statistical model factorial design was chosen. The partition coefficients, calculated by applying commercial drug design software, were correlated with chromatographic behaviour of these substances. After separation on Silica gel GF(254) using propano-lethanol-ammonium solution (25%) (8:2:0.3 v/v/v) as the mobile phase, the chromatographic zones corresponding to the spots were scanned at 254 nm. Analysing Maprotilin(R) tablets, Pertofran(R) dragees and Auromid(R) film tablets examined the applicability of the method for samples and dosage forms.
TY - JOUR
AU - Vujić, Zorica
AU - Radulović, D
AU - Lucić, B
AU - Erić, Slavica
AU - Kuntić, Vesna
PY - 2003
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/414
AB - Maprotiline, desipramine and moclobemide are widely used in the treatment of depression. The content of these antidepressants in bulk drug and pharmaceutical formulations were determined by TLC and in situ densitometry using a Camag scanner In order to achieve the best condition, mathematical statistical model factorial design was chosen. The partition coefficients, calculated by applying commercial drug design software, were correlated with chromatographic behaviour of these substances. After separation on Silica gel GF(254) using propano-lethanol-ammonium solution (25%) (8:2:0.3 v/v/v) as the mobile phase, the chromatographic zones corresponding to the spots were scanned at 254 nm. Analysing Maprotilin(R) tablets, Pertofran(R) dragees and Auromid(R) film tablets examined the applicability of the method for samples and dosage forms.
PB - Vieweg, Wiesbaden
T2 - Chromatographia
T1 - UV-densitometric determination of maprotiline, desipramine and moclobemide in pharmaceutical dosage forms
VL - 57
IS - 9-10
SP - 687
EP - 689
DO - 10.1007/BF02491750
ER -
@article{
author = "Vujić, Zorica and Radulović, D and Lucić, B and Erić, Slavica and Kuntić, Vesna",
year = "2003",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/414",
abstract = "Maprotiline, desipramine and moclobemide are widely used in the treatment of depression. The content of these antidepressants in bulk drug and pharmaceutical formulations were determined by TLC and in situ densitometry using a Camag scanner In order to achieve the best condition, mathematical statistical model factorial design was chosen. The partition coefficients, calculated by applying commercial drug design software, were correlated with chromatographic behaviour of these substances. After separation on Silica gel GF(254) using propano-lethanol-ammonium solution (25%) (8:2:0.3 v/v/v) as the mobile phase, the chromatographic zones corresponding to the spots were scanned at 254 nm. Analysing Maprotilin(R) tablets, Pertofran(R) dragees and Auromid(R) film tablets examined the applicability of the method for samples and dosage forms.",
publisher = "Vieweg, Wiesbaden",
journal = "Chromatographia",
title = "UV-densitometric determination of maprotiline, desipramine and moclobemide in pharmaceutical dosage forms",
volume = "57",
number = "9-10",
pages = "687-689",
doi = "10.1007/BF02491750"
}
Vujić, Z., Radulović, D., Lucić, B., Erić, S.,& Kuntić, V. (2003). UV-densitometric determination of maprotiline, desipramine and moclobemide in pharmaceutical dosage forms.
Chromatographia
Vieweg, Wiesbaden., 57(9-10), 687-689.
https://doi.org/10.1007/BF02491750
Vujić Z, Radulović D, Lucić B, Erić S, Kuntić V. UV-densitometric determination of maprotiline, desipramine and moclobemide in pharmaceutical dosage forms. Chromatographia. 2003;57(9-10):687-689
Vujić Zorica, Radulović D, Lucić B, Erić Slavica, Kuntić Vesna, "UV-densitometric determination of maprotiline, desipramine and moclobemide in pharmaceutical dosage forms" Chromatographia, 57, no. 9-10 (2003):687-689,
https://doi.org/10.1007/BF02491750 .
