UV-densitometric determination of maprotiline, desipramine and moclobemide in pharmaceutical dosage forms
Само за регистроване кориснике
2003
Чланак у часопису (Објављена верзија)

Метаподаци
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Maprotiline, desipramine and moclobemide are widely used in the treatment of depression. The content of these antidepressants in bulk drug and pharmaceutical formulations were determined by TLC and in situ densitometry using a Camag scanner In order to achieve the best condition, mathematical statistical model factorial design was chosen. The partition coefficients, calculated by applying commercial drug design software, were correlated with chromatographic behaviour of these substances. After separation on Silica gel GF(254) using propano-lethanol-ammonium solution (25%) (8:2:0.3 v/v/v) as the mobile phase, the chromatographic zones corresponding to the spots were scanned at 254 nm. Analysing Maprotilin(R) tablets, Pertofran(R) dragees and Auromid(R) film tablets examined the applicability of the method for samples and dosage forms.
Извор:
Chromatographia, 2003, 57, 9-10, 687-689Издавач:
- Vieweg, Wiesbaden
DOI: 10.1007/BF02491750
ISSN: 0009-5893