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Salting-out thin-layer chromatography of several myorelaxants

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2003
Authors
Aleksić, Mirjana
Odović, Jadranka
Milojković-Opsenica, Dušanka
Tešić, Živoslav
Article (Published version)
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Abstract
The chromatographic behavior of five myorelaxant drugs has been studied under the conditions used for salting-out thin-layer chromatography (SOTLC) on cellulose and alumina. For this purpose, aqueous ammonium sulfate solutions of different concentration were used as mobile phases. It was established that hR(F) values always decreased in parallel to increasing salt concentrations. When cellulose was used as adsorbent, a linear relationship was observed between the R-M values and the ammonium sulfate content of the mobile phase. Regression data of the plots obtained were used to determine the lipophilicity parameters R-M(0) and C-0. Lipophilicity determined in this way correlated with calculated log P values.
Source:
Journal of Planar Chromatography - Modern TLC, 2003, 16, 2, 144-146
Publisher:
  • Research Inst Medicinal Plants, Budakalasz

DOI: 10.1556/JPC.16.2003.2.11

ISSN: 0933-4173

WoS: 000183519300011

Scopus: 2-s2.0-0038282570
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/415
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Institution
Pharmacy

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