Salting-out thin-layer chromatography of several myorelaxants
Abstract
The chromatographic behavior of five myorelaxant drugs has been studied under the conditions used for salting-out thin-layer chromatography (SOTLC) on cellulose and alumina. For this purpose, aqueous ammonium sulfate solutions of different concentration were used as mobile phases. It was established that hR(F) values always decreased in parallel to increasing salt concentrations. When cellulose was used as adsorbent, a linear relationship was observed between the R-M values and the ammonium sulfate content of the mobile phase. Regression data of the plots obtained were used to determine the lipophilicity parameters R-M(0) and C-0. Lipophilicity determined in this way correlated with calculated log P values.
Source:
Journal of Planar Chromatography - Modern TLC, 2003, 16, 2, 144-146Publisher:
- Research Inst Medicinal Plants, Budakalasz
DOI: 10.1556/JPC.16.2003.2.11
ISSN: 0933-4173
WoS: 000183519300011
Scopus: 2-s2.0-0038282570
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Institution/Community
PharmacyTY - JOUR AU - Aleksić, Mirjana AU - Odović, Jadranka AU - Milojković-Opsenica, Dušanka AU - Tešić, Živoslav PY - 2003 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/415 AB - The chromatographic behavior of five myorelaxant drugs has been studied under the conditions used for salting-out thin-layer chromatography (SOTLC) on cellulose and alumina. For this purpose, aqueous ammonium sulfate solutions of different concentration were used as mobile phases. It was established that hR(F) values always decreased in parallel to increasing salt concentrations. When cellulose was used as adsorbent, a linear relationship was observed between the R-M values and the ammonium sulfate content of the mobile phase. Regression data of the plots obtained were used to determine the lipophilicity parameters R-M(0) and C-0. Lipophilicity determined in this way correlated with calculated log P values. PB - Research Inst Medicinal Plants, Budakalasz T2 - Journal of Planar Chromatography - Modern TLC T1 - Salting-out thin-layer chromatography of several myorelaxants VL - 16 IS - 2 SP - 144 EP - 146 DO - 10.1556/JPC.16.2003.2.11 ER -
@article{ author = "Aleksić, Mirjana and Odović, Jadranka and Milojković-Opsenica, Dušanka and Tešić, Živoslav", year = "2003", abstract = "The chromatographic behavior of five myorelaxant drugs has been studied under the conditions used for salting-out thin-layer chromatography (SOTLC) on cellulose and alumina. For this purpose, aqueous ammonium sulfate solutions of different concentration were used as mobile phases. It was established that hR(F) values always decreased in parallel to increasing salt concentrations. When cellulose was used as adsorbent, a linear relationship was observed between the R-M values and the ammonium sulfate content of the mobile phase. Regression data of the plots obtained were used to determine the lipophilicity parameters R-M(0) and C-0. Lipophilicity determined in this way correlated with calculated log P values.", publisher = "Research Inst Medicinal Plants, Budakalasz", journal = "Journal of Planar Chromatography - Modern TLC", title = "Salting-out thin-layer chromatography of several myorelaxants", volume = "16", number = "2", pages = "144-146", doi = "10.1556/JPC.16.2003.2.11" }
Aleksić, M., Odović, J., Milojković-Opsenica, D.,& Tešić, Ž.. (2003). Salting-out thin-layer chromatography of several myorelaxants. in Journal of Planar Chromatography - Modern TLC Research Inst Medicinal Plants, Budakalasz., 16(2), 144-146. https://doi.org/10.1556/JPC.16.2003.2.11
Aleksić M, Odović J, Milojković-Opsenica D, Tešić Ž. Salting-out thin-layer chromatography of several myorelaxants. in Journal of Planar Chromatography - Modern TLC. 2003;16(2):144-146. doi:10.1556/JPC.16.2003.2.11 .
Aleksić, Mirjana, Odović, Jadranka, Milojković-Opsenica, Dušanka, Tešić, Živoslav, "Salting-out thin-layer chromatography of several myorelaxants" in Journal of Planar Chromatography - Modern TLC, 16, no. 2 (2003):144-146, https://doi.org/10.1556/JPC.16.2003.2.11 . .