Factorial analysis of N-acetylcysteine and propolis treatment effects on symptoms, life quality and exacerbations in patients with Chronic Obstructive Pulmonary Disease (COPD): a randomized, double-blind, placebo-controlled trial
Authors
Kolarov, V.Kotur-Stevuljević, Jelena

Ilić, M.
Bogdan, M.
Tušek, B.
Agic, A.
Dugajlić, M.
Tot Vereš, K.
Kutlešić Stević, S.
Zvezdin, B.
Article (Published version)
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OBJECTIVE: Standard treatment for chronic obstructive pulmonary disease (COPD) includes inhalation therapy along with mucoactive drugs. The aim of this study was to assess the efficacy and safety of orally administered mucolytic N-acetylcysteine and propolis (NACp) in COPD patients. PATIENTS AND METHODS: A randomized, double-blind, prospective, interventional, 6 months study was conducted at the Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia. Effects of daily NACp administration (600 mg, 1200 mg or placebo) on exacerbation, life quality (St. George's Respiratory Questionnaire-SGRQ), symptoms (COPD assessment test-CAT; Visual analogue cough scale-VAS; Leicester Cough Questionnaire-LCQ; Medical Research Council Dyspnoea scale-mMRC) and spirometric parameters in 120 COPD patients were assessed. Tests were conducted at three-time points: baseline, after three months and after 6 months of NACp treatment. RESULTS: Repeated measures ANOVA showed that pulmonary functio...n parameters, 6-minute walk test and mMRC score did not significantly change during the study. Cough VAS and CAT scores were significantly different between groups as within experimental groups. LCQ and SGRQ scores did not differ between placebo, and both examined groups, but within each examined group statistically significant difference was confirmed in observed parameters during therapy. Factorial analysis and subsequent binary logistic regression revealed "Symptoms related factor" as the strongest predictor of exacerbation for supplemented groups (p<0.01). CONCLUSIONS: Treatment with high NACp for 6 months is safe and beneficial for cough and expectoration symptoms and improves the life quality. NACp significantly reduces acute exacerbation frequency in COPD patients by controlling COPD related symptoms.
Keywords:
COPD / NAC / Propolis / Exacerbation / Cough / Life qualitySource:
European Review for Medical and Pharmacological Sciences, 2022, 26, 9, 3192-3199Publisher:
- Verduci Editore srl
DOI: 10.26355/eurrev_202205_28737
ISSN: 1128-3602
WoS: 00083294640001
Scopus: 2-s2.0-85130249551
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PharmacyTY - JOUR AU - Kolarov, V. AU - Kotur-Stevuljević, Jelena AU - Ilić, M. AU - Bogdan, M. AU - Tušek, B. AU - Agic, A. AU - Dugajlić, M. AU - Tot Vereš, K. AU - Kutlešić Stević, S. AU - Zvezdin, B. PY - 2022 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4176 AB - OBJECTIVE: Standard treatment for chronic obstructive pulmonary disease (COPD) includes inhalation therapy along with mucoactive drugs. The aim of this study was to assess the efficacy and safety of orally administered mucolytic N-acetylcysteine and propolis (NACp) in COPD patients. PATIENTS AND METHODS: A randomized, double-blind, prospective, interventional, 6 months study was conducted at the Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia. Effects of daily NACp administration (600 mg, 1200 mg or placebo) on exacerbation, life quality (St. George's Respiratory Questionnaire-SGRQ), symptoms (COPD assessment test-CAT; Visual analogue cough scale-VAS; Leicester Cough Questionnaire-LCQ; Medical Research Council Dyspnoea scale-mMRC) and spirometric parameters in 120 COPD patients were assessed. Tests were conducted at three-time points: baseline, after three months and after 6 months of NACp treatment. RESULTS: Repeated measures ANOVA showed that pulmonary function parameters, 6-minute walk test and mMRC score did not significantly change during the study. Cough VAS and CAT scores were significantly different between groups as within experimental groups. LCQ and SGRQ scores did not differ between placebo, and both examined groups, but within each examined group statistically significant difference was confirmed in observed parameters during therapy. Factorial analysis and subsequent binary logistic regression revealed "Symptoms related factor" as the strongest predictor of exacerbation for supplemented groups (p<0.01). CONCLUSIONS: Treatment with high NACp for 6 months is safe and beneficial for cough and expectoration symptoms and improves the life quality. NACp significantly reduces acute exacerbation frequency in COPD patients by controlling COPD related symptoms. PB - Verduci Editore srl T2 - European Review for Medical and Pharmacological Sciences T1 - Factorial analysis of N-acetylcysteine and propolis treatment effects on symptoms, life quality and exacerbations in patients with Chronic Obstructive Pulmonary Disease (COPD): a randomized, double-blind, placebo-controlled trial VL - 26 IS - 9 SP - 3192 EP - 3199 DO - 10.26355/eurrev_202205_28737 ER -
@article{ author = "Kolarov, V. and Kotur-Stevuljević, Jelena and Ilić, M. and Bogdan, M. and Tušek, B. and Agic, A. and Dugajlić, M. and Tot Vereš, K. and Kutlešić Stević, S. and Zvezdin, B.", year = "2022", abstract = "OBJECTIVE: Standard treatment for chronic obstructive pulmonary disease (COPD) includes inhalation therapy along with mucoactive drugs. The aim of this study was to assess the efficacy and safety of orally administered mucolytic N-acetylcysteine and propolis (NACp) in COPD patients. PATIENTS AND METHODS: A randomized, double-blind, prospective, interventional, 6 months study was conducted at the Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia. Effects of daily NACp administration (600 mg, 1200 mg or placebo) on exacerbation, life quality (St. George's Respiratory Questionnaire-SGRQ), symptoms (COPD assessment test-CAT; Visual analogue cough scale-VAS; Leicester Cough Questionnaire-LCQ; Medical Research Council Dyspnoea scale-mMRC) and spirometric parameters in 120 COPD patients were assessed. Tests were conducted at three-time points: baseline, after three months and after 6 months of NACp treatment. RESULTS: Repeated measures ANOVA showed that pulmonary function parameters, 6-minute walk test and mMRC score did not significantly change during the study. Cough VAS and CAT scores were significantly different between groups as within experimental groups. LCQ and SGRQ scores did not differ between placebo, and both examined groups, but within each examined group statistically significant difference was confirmed in observed parameters during therapy. Factorial analysis and subsequent binary logistic regression revealed "Symptoms related factor" as the strongest predictor of exacerbation for supplemented groups (p<0.01). CONCLUSIONS: Treatment with high NACp for 6 months is safe and beneficial for cough and expectoration symptoms and improves the life quality. NACp significantly reduces acute exacerbation frequency in COPD patients by controlling COPD related symptoms.", publisher = "Verduci Editore srl", journal = "European Review for Medical and Pharmacological Sciences", title = "Factorial analysis of N-acetylcysteine and propolis treatment effects on symptoms, life quality and exacerbations in patients with Chronic Obstructive Pulmonary Disease (COPD): a randomized, double-blind, placebo-controlled trial", volume = "26", number = "9", pages = "3192-3199", doi = "10.26355/eurrev_202205_28737" }
Kolarov, V., Kotur-Stevuljević, J., Ilić, M., Bogdan, M., Tušek, B., Agic, A., Dugajlić, M., Tot Vereš, K., Kutlešić Stević, S.,& Zvezdin, B.. (2022). Factorial analysis of N-acetylcysteine and propolis treatment effects on symptoms, life quality and exacerbations in patients with Chronic Obstructive Pulmonary Disease (COPD): a randomized, double-blind, placebo-controlled trial. in European Review for Medical and Pharmacological Sciences Verduci Editore srl., 26(9), 3192-3199. https://doi.org/10.26355/eurrev_202205_28737
Kolarov V, Kotur-Stevuljević J, Ilić M, Bogdan M, Tušek B, Agic A, Dugajlić M, Tot Vereš K, Kutlešić Stević S, Zvezdin B. Factorial analysis of N-acetylcysteine and propolis treatment effects on symptoms, life quality and exacerbations in patients with Chronic Obstructive Pulmonary Disease (COPD): a randomized, double-blind, placebo-controlled trial. in European Review for Medical and Pharmacological Sciences. 2022;26(9):3192-3199. doi:10.26355/eurrev_202205_28737 .
Kolarov, V., Kotur-Stevuljević, Jelena, Ilić, M., Bogdan, M., Tušek, B., Agic, A., Dugajlić, M., Tot Vereš, K., Kutlešić Stević, S., Zvezdin, B., "Factorial analysis of N-acetylcysteine and propolis treatment effects on symptoms, life quality and exacerbations in patients with Chronic Obstructive Pulmonary Disease (COPD): a randomized, double-blind, placebo-controlled trial" in European Review for Medical and Pharmacological Sciences, 26, no. 9 (2022):3192-3199, https://doi.org/10.26355/eurrev_202205_28737 . .