Chemistry of some synthetic antihyperglycemics

Abstract

Chemistry of some non-insulin dependent diabetes mellitus (type 2) such as sulfonylurea derivatives, glinides, biguanides and thiazolidinedione is shown. The relationship between chemical structures and the molecular mechanism of action are presented.

U terapiji insulin nezavisnog dijabetesa (tip 2) koriste se derivati sulfonilureje, bigvanidina, tiazolidindiona i inhibitori alfa glukozidaze. U ovom radu je prikazan odnos hemijske strukture i aktivnosti nekih sintetskih antihiperglikemika.