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Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy

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2003
Authors
Popović, Gordana
Sladić, Dušan
Stefanović, Violeta M.
Pfendt, Lidija
Article (Published version)
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Abstract
Protolytic equilibria in homogeneous and heterogeneous systems of lorazepam and oxazepam, which are sparingly soluble ampholytes from the class of 1,4-benzodiazepines, were studied at 25 degreesC and ionic strength of 0.1 M. Acidity constants and equilibrium constants in a heterogeneous system were determined. On the basis of the analysis of the corresponding C-13- and H-1-NMR spectra, deprotonation site in the molecules of the investigated compounds was predicted. Finally, the correlation between chemical shifts in the H-1-NMR spectra and the acidity of the amide proton of 1,4-benzodiazepines was established.
Source:
Journal of Pharmaceutical and Biomedical Analysis, 2003, 31, 4, 693-699
Publisher:
  • Pergamon-Elsevier Science Ltd, Oxford

DOI: 10.1016/S0731-7085(02)00686-6

ISSN: 0731-7085

PubMed: 12644196

WoS: 000181951300010

Scopus: 2-s2.0-0037467186
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/418
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Institution
Pharmacy

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