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Telomere length as a biomarker of aging and diseases

Dužina telomera kao biomarker starenja i bolesti

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2022
Telomere_length_as_pub_2022.pdf (496.0Kb)
Authors
Guzonjić, Azra
Sopić, Miron
Ostanek, Barbara
Kotur-Stevuljević, Jelena
Article (Published version)
Metadata
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Abstract
As research related to healthspan and lifespan has become a hot topic, the necessity for a reliable and practical biomarker of aging (BoA), which can provide information about mortality and morbidity risk, along with remaining life expectancy, has increased. The chromosome terminus non-coding protective structure that prevents genomic instability is called a telomere. The continual shortening of telomeres, which affects their structure as well as function, is a hallmark of agedness. The aforementioned process is a potential cause of age-related diseases (ARDs), leading to a bad prognosis and a low survival rate, which compromise health and longevity. Hence, studies scrutinizing the BoAs often include telomere length (TL) as a prospective candidate. The results of these studies suggest that TL measurement can only provide an approximate appraisal of the aging rate, and its implementation into clinical practice and routine use as a BoA has many limitations and challenges. Never...theless, measuring TL while determining other biomarkers can be used to assess biological age. This review focuses on the importance of telomeres in health, senescence, and diseases, as well as on summarizing the results and conclusions of previous studies evaluating TL as a potential BoA.

Kako su istraživanja na temu starenja postala sve popularnija, javila se potreba za pouzdanim i praktičnim biomarkerom starenja, koji može pružiti informacije o riziku od mortaliteta i morbiditeta. Telomere su nekodirajući krajevi linearnih hromozoma koji održavaju njihovu stabilnost i integritet. Ćelijsko starenje i starenje organizma karakteriše progresivno skraćivanje telomera, što ugrožava njihovu strukturu i funkciju. Skraćivanje telomera je u vezi sa povećanom incidencom bolesti povezanih sa starenjem i lošom stopom preživljavanja, što ugrožava zdravlje i skraćuje životni vek. Stoga je dužina telomera dugo vremena prepoznata kao jedan od najboljih biomarkera starenja. Međutim, nedavna istraživanja ukazuju na to da dužina telomera može da pruži samo približnu procenu brzine starenja, pa je implementacija ovog biomarkera u kliničku praksu i rutinsku primenu praćena mnogim ograničenjima i izazovima. Uprkos tome, merenje dužine telomera, uz istovremeno određivanje drugih biomarkera, ...može poslužiti za procenu biološke starosti. Fokus ovog rada je na značaju telomera u ljudskom zdravlju, starenju i bolestima, kao i na sumiranju rezultata i zaključaka dosadašnjih studija koje su se bavile ispitivanjem dužine telomera kao potencijalnog kandidata za biomarker starenja.

Keywords:
Telomere length / biomarker of aging / telomerase / age-related diseases / dužina telomera / biomarker starenja / telomeraza / bolesti povezane sa starenjem
Source:
Arhiv za farmaciju, 2022, 72, 2, 105-126
Publisher:
  • Beograd : Savez farmaceutskih udruženja Srbije

DOI: 10.5937/arhfarm72-36376

ISSN: 0004-1963

Scopus: 2-s2.0-85135623508
[ Google Scholar ]
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/4185
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Guzonjić, Azra
AU  - Sopić, Miron
AU  - Ostanek, Barbara
AU  - Kotur-Stevuljević, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4185
AB  - As research related to healthspan and lifespan has become a hot topic, the necessity for a
reliable and practical biomarker of aging (BoA), which can provide information about mortality
and morbidity risk, along with remaining life expectancy, has increased. The chromosome
terminus non-coding protective structure that prevents genomic instability is called a telomere.
The continual shortening of telomeres, which affects their structure as well as function, is a
hallmark of agedness. The aforementioned process is a potential cause of age-related diseases
(ARDs), leading to a bad prognosis and a low survival rate, which compromise health and
longevity. Hence, studies scrutinizing the BoAs often include telomere length (TL) as a
prospective candidate. The results of these studies suggest that TL measurement can only provide
an approximate appraisal of the aging rate, and its implementation into clinical practice and
routine use as a BoA has many limitations and challenges. Nevertheless, measuring TL while
determining other biomarkers can be used to assess biological age. This review focuses on the
importance of telomeres in health, senescence, and diseases, as well as on summarizing the results
and conclusions of previous studies evaluating TL as a potential BoA.
AB  - Kako su istraživanja na temu starenja postala sve popularnija, javila se potreba za pouzdanim i praktičnim biomarkerom starenja, koji može pružiti informacije o riziku od mortaliteta i morbiditeta. Telomere su nekodirajući krajevi linearnih hromozoma koji održavaju njihovu stabilnost i integritet. Ćelijsko starenje i starenje organizma karakteriše progresivno skraćivanje telomera, što ugrožava njihovu strukturu i funkciju. Skraćivanje telomera je u vezi sa povećanom incidencom bolesti povezanih sa starenjem i lošom stopom preživljavanja, što ugrožava zdravlje i skraćuje životni vek. Stoga je dužina telomera dugo vremena prepoznata kao jedan od najboljih biomarkera starenja. Međutim, nedavna istraživanja ukazuju na to da dužina telomera može da pruži samo približnu procenu brzine starenja, pa je implementacija ovog biomarkera u kliničku praksu i rutinsku primenu praćena mnogim ograničenjima i izazovima. Uprkos tome, merenje dužine telomera, uz istovremeno određivanje drugih biomarkera, može poslužiti za procenu biološke starosti. Fokus ovog rada je na značaju telomera u ljudskom zdravlju, starenju i bolestima, kao i na sumiranju rezultata i zaključaka dosadašnjih studija koje su se bavile ispitivanjem dužine telomera kao potencijalnog kandidata za biomarker starenja.
PB  - Beograd : Savez farmaceutskih udruženja Srbije
T2  - Arhiv za farmaciju
T1  - Telomere length as a biomarker of aging and diseases
T1  - Dužina telomera kao biomarker starenja i bolesti
VL  - 72
IS  - 2
SP  - 105
EP  - 126
DO  - 10.5937/arhfarm72-36376
ER  - 
@article{
author = "Guzonjić, Azra and Sopić, Miron and Ostanek, Barbara and Kotur-Stevuljević, Jelena",
year = "2022",
abstract = "As research related to healthspan and lifespan has become a hot topic, the necessity for a
reliable and practical biomarker of aging (BoA), which can provide information about mortality
and morbidity risk, along with remaining life expectancy, has increased. The chromosome
terminus non-coding protective structure that prevents genomic instability is called a telomere.
The continual shortening of telomeres, which affects their structure as well as function, is a
hallmark of agedness. The aforementioned process is a potential cause of age-related diseases
(ARDs), leading to a bad prognosis and a low survival rate, which compromise health and
longevity. Hence, studies scrutinizing the BoAs often include telomere length (TL) as a
prospective candidate. The results of these studies suggest that TL measurement can only provide
an approximate appraisal of the aging rate, and its implementation into clinical practice and
routine use as a BoA has many limitations and challenges. Nevertheless, measuring TL while
determining other biomarkers can be used to assess biological age. This review focuses on the
importance of telomeres in health, senescence, and diseases, as well as on summarizing the results
and conclusions of previous studies evaluating TL as a potential BoA., Kako su istraživanja na temu starenja postala sve popularnija, javila se potreba za pouzdanim i praktičnim biomarkerom starenja, koji može pružiti informacije o riziku od mortaliteta i morbiditeta. Telomere su nekodirajući krajevi linearnih hromozoma koji održavaju njihovu stabilnost i integritet. Ćelijsko starenje i starenje organizma karakteriše progresivno skraćivanje telomera, što ugrožava njihovu strukturu i funkciju. Skraćivanje telomera je u vezi sa povećanom incidencom bolesti povezanih sa starenjem i lošom stopom preživljavanja, što ugrožava zdravlje i skraćuje životni vek. Stoga je dužina telomera dugo vremena prepoznata kao jedan od najboljih biomarkera starenja. Međutim, nedavna istraživanja ukazuju na to da dužina telomera može da pruži samo približnu procenu brzine starenja, pa je implementacija ovog biomarkera u kliničku praksu i rutinsku primenu praćena mnogim ograničenjima i izazovima. Uprkos tome, merenje dužine telomera, uz istovremeno određivanje drugih biomarkera, može poslužiti za procenu biološke starosti. Fokus ovog rada je na značaju telomera u ljudskom zdravlju, starenju i bolestima, kao i na sumiranju rezultata i zaključaka dosadašnjih studija koje su se bavile ispitivanjem dužine telomera kao potencijalnog kandidata za biomarker starenja.",
publisher = "Beograd : Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "Telomere length as a biomarker of aging and diseases, Dužina telomera kao biomarker starenja i bolesti",
volume = "72",
number = "2",
pages = "105-126",
doi = "10.5937/arhfarm72-36376"
}
Guzonjić, A., Sopić, M., Ostanek, B.,& Kotur-Stevuljević, J.. (2022). Telomere length as a biomarker of aging and diseases. in Arhiv za farmaciju
Beograd : Savez farmaceutskih udruženja Srbije., 72(2), 105-126.
https://doi.org/10.5937/arhfarm72-36376
Guzonjić A, Sopić M, Ostanek B, Kotur-Stevuljević J. Telomere length as a biomarker of aging and diseases. in Arhiv za farmaciju. 2022;72(2):105-126.
doi:10.5937/arhfarm72-36376 .
Guzonjić, Azra, Sopić, Miron, Ostanek, Barbara, Kotur-Stevuljević, Jelena, "Telomere length as a biomarker of aging and diseases" in Arhiv za farmaciju, 72, no. 2 (2022):105-126,
https://doi.org/10.5937/arhfarm72-36376 . .

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