Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy
Samo za registrovane korisnike
2003
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Protolytic equilibria in homogeneous and heterogeneous systems of lorazepam and oxazepam, which are sparingly soluble ampholytes from the class of 1,4-benzodiazepines, were studied at 25 degreesC and ionic strength of 0.1 M. Acidity constants and equilibrium constants in a heterogeneous system were determined. On the basis of the analysis of the corresponding C-13- and H-1-NMR spectra, deprotonation site in the molecules of the investigated compounds was predicted. Finally, the correlation between chemical shifts in the H-1-NMR spectra and the acidity of the amide proton of 1,4-benzodiazepines was established.
Izvor:
Journal of Pharmaceutical and Biomedical Analysis, 2003, 31, 4, 693-699Izdavač:
- Pergamon-Elsevier Science Ltd, Oxford
DOI: 10.1016/S0731-7085(02)00686-6
ISSN: 0731-7085
PubMed: 12644196
WoS: 000181951300010
Scopus: 2-s2.0-0037467186
Institucija/grupa
PharmacyTY - JOUR AU - Popović, Gordana AU - Sladić, Dušan AU - Stefanović, Violeta M. AU - Pfendt, Lidija PY - 2003 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/418 AB - Protolytic equilibria in homogeneous and heterogeneous systems of lorazepam and oxazepam, which are sparingly soluble ampholytes from the class of 1,4-benzodiazepines, were studied at 25 degreesC and ionic strength of 0.1 M. Acidity constants and equilibrium constants in a heterogeneous system were determined. On the basis of the analysis of the corresponding C-13- and H-1-NMR spectra, deprotonation site in the molecules of the investigated compounds was predicted. Finally, the correlation between chemical shifts in the H-1-NMR spectra and the acidity of the amide proton of 1,4-benzodiazepines was established. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Journal of Pharmaceutical and Biomedical Analysis T1 - Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy VL - 31 IS - 4 SP - 693 EP - 699 DO - 10.1016/S0731-7085(02)00686-6 ER -
@article{ author = "Popović, Gordana and Sladić, Dušan and Stefanović, Violeta M. and Pfendt, Lidija", year = "2003", abstract = "Protolytic equilibria in homogeneous and heterogeneous systems of lorazepam and oxazepam, which are sparingly soluble ampholytes from the class of 1,4-benzodiazepines, were studied at 25 degreesC and ionic strength of 0.1 M. Acidity constants and equilibrium constants in a heterogeneous system were determined. On the basis of the analysis of the corresponding C-13- and H-1-NMR spectra, deprotonation site in the molecules of the investigated compounds was predicted. Finally, the correlation between chemical shifts in the H-1-NMR spectra and the acidity of the amide proton of 1,4-benzodiazepines was established.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Journal of Pharmaceutical and Biomedical Analysis", title = "Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy", volume = "31", number = "4", pages = "693-699", doi = "10.1016/S0731-7085(02)00686-6" }
Popović, G., Sladić, D., Stefanović, V. M.,& Pfendt, L.. (2003). Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy. in Journal of Pharmaceutical and Biomedical Analysis Pergamon-Elsevier Science Ltd, Oxford., 31(4), 693-699. https://doi.org/10.1016/S0731-7085(02)00686-6
Popović G, Sladić D, Stefanović VM, Pfendt L. Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy. in Journal of Pharmaceutical and Biomedical Analysis. 2003;31(4):693-699. doi:10.1016/S0731-7085(02)00686-6 .
Popović, Gordana, Sladić, Dušan, Stefanović, Violeta M., Pfendt, Lidija, "Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy" in Journal of Pharmaceutical and Biomedical Analysis, 31, no. 4 (2003):693-699, https://doi.org/10.1016/S0731-7085(02)00686-6 . .