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dc.creatorPopović, Gordana
dc.creatorSladić, Dušan
dc.creatorStefanović, Violeta M.
dc.creatorPfendt, Lidija
dc.date.accessioned2019-09-02T10:56:37Z
dc.date.available2019-09-02T10:56:37Z
dc.date.issued2003
dc.identifier.issn0731-7085
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/418
dc.description.abstractProtolytic equilibria in homogeneous and heterogeneous systems of lorazepam and oxazepam, which are sparingly soluble ampholytes from the class of 1,4-benzodiazepines, were studied at 25 degreesC and ionic strength of 0.1 M. Acidity constants and equilibrium constants in a heterogeneous system were determined. On the basis of the analysis of the corresponding C-13- and H-1-NMR spectra, deprotonation site in the molecules of the investigated compounds was predicted. Finally, the correlation between chemical shifts in the H-1-NMR spectra and the acidity of the amide proton of 1,4-benzodiazepines was established.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.rightsrestrictedAccess
dc.sourceJournal of Pharmaceutical and Biomedical Analysis
dc.titleStudy on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПфендт, Лидија; Сладић, Душан; Стефановић, Виолета М.; Поповић, Гордана;
dc.citation.volume31
dc.citation.issue4
dc.citation.spage693
dc.citation.epage699
dc.citation.other31(4): 693-699
dc.citation.rankM22
dc.identifier.wos000181951300010
dc.identifier.doi10.1016/S0731-7085(02)00686-6
dc.identifier.pmid12644196
dc.identifier.scopus2-s2.0-0037467186
dc.identifier.rcubconv_1393
dc.type.versionpublishedVersion


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