dc.creator | Popović, Gordana | |
dc.creator | Sladić, Dušan | |
dc.creator | Stefanović, Violeta M. | |
dc.creator | Pfendt, Lidija | |
dc.date.accessioned | 2019-09-02T10:56:37Z | |
dc.date.available | 2019-09-02T10:56:37Z | |
dc.date.issued | 2003 | |
dc.identifier.issn | 0731-7085 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/418 | |
dc.description.abstract | Protolytic equilibria in homogeneous and heterogeneous systems of lorazepam and oxazepam, which are sparingly soluble ampholytes from the class of 1,4-benzodiazepines, were studied at 25 degreesC and ionic strength of 0.1 M. Acidity constants and equilibrium constants in a heterogeneous system were determined. On the basis of the analysis of the corresponding C-13- and H-1-NMR spectra, deprotonation site in the molecules of the investigated compounds was predicted. Finally, the correlation between chemical shifts in the H-1-NMR spectra and the acidity of the amide proton of 1,4-benzodiazepines was established. | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.rights | restrictedAccess | |
dc.source | Journal of Pharmaceutical and Biomedical Analysis | |
dc.title | Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Пфендт, Лидија; Сладић, Душан; Стефановић, Виолета М.; Поповић, Гордана; | |
dc.citation.volume | 31 | |
dc.citation.issue | 4 | |
dc.citation.spage | 693 | |
dc.citation.epage | 699 | |
dc.citation.other | 31(4): 693-699 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000181951300010 | |
dc.identifier.doi | 10.1016/S0731-7085(02)00686-6 | |
dc.identifier.pmid | 12644196 | |
dc.identifier.scopus | 2-s2.0-0037467186 | |
dc.type.version | publishedVersion | |