New azamacrocyclic binuclear Cu(II) aminocarboxylate complexes: Structural, magnetic, spectral and antiproliferative studies
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2022
Authors
Antonijević Nikolić, MirjanaDražić, Branka

Beata, Cristóvão
Bartyzel, Agata
Miroslaw, Barbara
Tanasković, Slađana

Article (Published version)

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New cationic complexes of Cu(II) with bridged aminocarboxylates: glycine and alanine, as well as octaazamacrocyclic ligand N,N',N'',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc), with general formula [Cu2(L)tpmc](ClO4)4∙Y, (1): L=glycine, Y=2H2O and (2): L=alanine, Y=CH3CN were synthesized. Characterization of the complexes was performed by elemental analysis (C, H, N, Cu), UV/Vis, FTIR spectroscopy and magnetic measurements. The single crystal X-ray analyses results show that reported compounds were obtained as hydrates with formulae [Cu2(gly)tpmc](ClO4)4⋅6.5H2O (M1) and [Cu2(ala)tpmc](ClO4)4⋅5H2O (M2). They crystallize in the orthorhombic system, P212121 space group. The metal centers are bridged by the carboxylate group of the glycine/alanine and bound via nitrogen atoms of tmpc. In the complex M1/M2, geometry around Cu(II) coordination sphere is square pyramidal (M1: τ5 = 0.10/0.33; M2: τ5 = 0.04/0.30). In the crystal structure of M1 and M2 the amino acids... exist as a zwitterion. The temperature dependence of magnetic susceptibility indicated very weak ferromagnetic interaction between two Cu(II) ions. The antiproliferative effect of the complexes, the free ligands, and cis-platin, as referent cytostatic drug, were tested against human leukemia monocytic cell line (THP-1), leukemic T cell lymphoblast (JURKAT) and Human Caucasian Burkitt′s lymphoma (RAMOS). The IC50 values for the complexes were from 37.9 ± 2.6 to 63.05 ± 0.72 µM.
Keywords:
Cu(II) complexes / Octaazamacrocycle / Antiproliferative activity / Glycine and alanineSource:
Journal of Molecular Structure, 2022, 1252Publisher:
- Elsevier B.V.
Funding / projects:
DOI: 10.1016/j.molstruc.2021.131969
ISSN: 0022-2860
WoS: 000744735400014
Scopus: 2-s2.0-85121210625
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PharmacyTY - JOUR AU - Antonijević Nikolić, Mirjana AU - Dražić, Branka AU - Beata, Cristóvão AU - Bartyzel, Agata AU - Miroslaw, Barbara AU - Tanasković, Slađana PY - 2022 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4193 AB - New cationic complexes of Cu(II) with bridged aminocarboxylates: glycine and alanine, as well as octaazamacrocyclic ligand N,N',N'',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc), with general formula [Cu2(L)tpmc](ClO4)4∙Y, (1): L=glycine, Y=2H2O and (2): L=alanine, Y=CH3CN were synthesized. Characterization of the complexes was performed by elemental analysis (C, H, N, Cu), UV/Vis, FTIR spectroscopy and magnetic measurements. The single crystal X-ray analyses results show that reported compounds were obtained as hydrates with formulae [Cu2(gly)tpmc](ClO4)4⋅6.5H2O (M1) and [Cu2(ala)tpmc](ClO4)4⋅5H2O (M2). They crystallize in the orthorhombic system, P212121 space group. The metal centers are bridged by the carboxylate group of the glycine/alanine and bound via nitrogen atoms of tmpc. In the complex M1/M2, geometry around Cu(II) coordination sphere is square pyramidal (M1: τ5 = 0.10/0.33; M2: τ5 = 0.04/0.30). In the crystal structure of M1 and M2 the amino acids exist as a zwitterion. The temperature dependence of magnetic susceptibility indicated very weak ferromagnetic interaction between two Cu(II) ions. The antiproliferative effect of the complexes, the free ligands, and cis-platin, as referent cytostatic drug, were tested against human leukemia monocytic cell line (THP-1), leukemic T cell lymphoblast (JURKAT) and Human Caucasian Burkitt′s lymphoma (RAMOS). The IC50 values for the complexes were from 37.9 ± 2.6 to 63.05 ± 0.72 µM. PB - Elsevier B.V. T2 - Journal of Molecular Structure T1 - New azamacrocyclic binuclear Cu(II) aminocarboxylate complexes: Structural, magnetic, spectral and antiproliferative studies VL - 1252 DO - 10.1016/j.molstruc.2021.131969 ER -
@article{ author = "Antonijević Nikolić, Mirjana and Dražić, Branka and Beata, Cristóvão and Bartyzel, Agata and Miroslaw, Barbara and Tanasković, Slađana", year = "2022", abstract = "New cationic complexes of Cu(II) with bridged aminocarboxylates: glycine and alanine, as well as octaazamacrocyclic ligand N,N',N'',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc), with general formula [Cu2(L)tpmc](ClO4)4∙Y, (1): L=glycine, Y=2H2O and (2): L=alanine, Y=CH3CN were synthesized. Characterization of the complexes was performed by elemental analysis (C, H, N, Cu), UV/Vis, FTIR spectroscopy and magnetic measurements. The single crystal X-ray analyses results show that reported compounds were obtained as hydrates with formulae [Cu2(gly)tpmc](ClO4)4⋅6.5H2O (M1) and [Cu2(ala)tpmc](ClO4)4⋅5H2O (M2). They crystallize in the orthorhombic system, P212121 space group. The metal centers are bridged by the carboxylate group of the glycine/alanine and bound via nitrogen atoms of tmpc. In the complex M1/M2, geometry around Cu(II) coordination sphere is square pyramidal (M1: τ5 = 0.10/0.33; M2: τ5 = 0.04/0.30). In the crystal structure of M1 and M2 the amino acids exist as a zwitterion. The temperature dependence of magnetic susceptibility indicated very weak ferromagnetic interaction between two Cu(II) ions. The antiproliferative effect of the complexes, the free ligands, and cis-platin, as referent cytostatic drug, were tested against human leukemia monocytic cell line (THP-1), leukemic T cell lymphoblast (JURKAT) and Human Caucasian Burkitt′s lymphoma (RAMOS). The IC50 values for the complexes were from 37.9 ± 2.6 to 63.05 ± 0.72 µM.", publisher = "Elsevier B.V.", journal = "Journal of Molecular Structure", title = "New azamacrocyclic binuclear Cu(II) aminocarboxylate complexes: Structural, magnetic, spectral and antiproliferative studies", volume = "1252", doi = "10.1016/j.molstruc.2021.131969" }
Antonijević Nikolić, M., Dražić, B., Beata, C., Bartyzel, A., Miroslaw, B.,& Tanasković, S.. (2022). New azamacrocyclic binuclear Cu(II) aminocarboxylate complexes: Structural, magnetic, spectral and antiproliferative studies. in Journal of Molecular Structure Elsevier B.V.., 1252. https://doi.org/10.1016/j.molstruc.2021.131969
Antonijević Nikolić M, Dražić B, Beata C, Bartyzel A, Miroslaw B, Tanasković S. New azamacrocyclic binuclear Cu(II) aminocarboxylate complexes: Structural, magnetic, spectral and antiproliferative studies. in Journal of Molecular Structure. 2022;1252. doi:10.1016/j.molstruc.2021.131969 .
Antonijević Nikolić, Mirjana, Dražić, Branka, Beata, Cristóvão, Bartyzel, Agata, Miroslaw, Barbara, Tanasković, Slađana, "New azamacrocyclic binuclear Cu(II) aminocarboxylate complexes: Structural, magnetic, spectral and antiproliferative studies" in Journal of Molecular Structure, 1252 (2022), https://doi.org/10.1016/j.molstruc.2021.131969 . .