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dc.creatorAntonijević Nikolić, Mirjana
dc.creatorDražić, Branka
dc.creatorBeata, Cristóvão
dc.creatorBartyzel, Agata
dc.creatorMiroslaw, Barbara
dc.creatorTanasković, Slađana
dc.date.accessioned2022-07-05T12:42:41Z
dc.date.available2022-07-05T12:42:41Z
dc.date.issued2022
dc.identifier.issn0022-2860
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/4193
dc.description.abstractNew cationic complexes of Cu(II) with bridged aminocarboxylates: glycine and alanine, as well as octaazamacrocyclic ligand N,N',N'',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc), with general formula [Cu2(L)tpmc](ClO4)4∙Y, (1): L=glycine, Y=2H2O and (2): L=alanine, Y=CH3CN were synthesized. Characterization of the complexes was performed by elemental analysis (C, H, N, Cu), UV/Vis, FTIR spectroscopy and magnetic measurements. The single crystal X-ray analyses results show that reported compounds were obtained as hydrates with formulae [Cu2(gly)tpmc](ClO4)4⋅6.5H2O (M1) and [Cu2(ala)tpmc](ClO4)4⋅5H2O (M2). They crystallize in the orthorhombic system, P212121 space group. The metal centers are bridged by the carboxylate group of the glycine/alanine and bound via nitrogen atoms of tmpc. In the complex M1/M2, geometry around Cu(II) coordination sphere is square pyramidal (M1: τ5 = 0.10/0.33; M2: τ5 = 0.04/0.30). In the crystal structure of M1 and M2 the amino acids exist as a zwitterion. The temperature dependence of magnetic susceptibility indicated very weak ferromagnetic interaction between two Cu(II) ions. The antiproliferative effect of the complexes, the free ligands, and cis-platin, as referent cytostatic drug, were tested against human leukemia monocytic cell line (THP-1), leukemic T cell lymphoblast (JURKAT) and Human Caucasian Burkitt′s lymphoma (RAMOS). The IC50 values for the complexes were from 37.9 ± 2.6 to 63.05 ± 0.72 µM.sr
dc.language.isoensr
dc.publisherElsevier B.V.sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//sr
dc.rightsrestrictedAccesssr
dc.sourceJournal of Molecular Structuresr
dc.subjectCu(II) complexessr
dc.subjectOctaazamacrocyclesr
dc.subjectAntiproliferative activitysr
dc.subjectGlycine and alaninesr
dc.titleNew azamacrocyclic binuclear Cu(II) aminocarboxylate complexes: Structural, magnetic, spectral and antiproliferative studiessr
dc.typearticlesr
dc.rights.licenseARRsr
dc.citation.volume1252
dc.citation.rankM22
dc.identifier.wos000744735400014
dc.identifier.doi10.1016/j.molstruc.2021.131969
dc.identifier.scopus2-s2.0-85121210625
dc.type.versionpublishedVersionsr


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Приказ основних података о документу