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Quantitative analysis of nimesulide in plasma by thin-layer chromatography: Application to pharmacokinetic studies in man

Samo za registrovane korisnike
2003
Autori
Miljković, Branislava
Brzaković, B
Kovacević, I
Agbaba, Danica
Pokrajac, Milena
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentu
Apstrakt
A thin-layer chromatographic (TLC) method for quantitative analysis of nimesulide in human plasma has been developed, validated, and applied to a pharmacokinetic study of healthy volunteers. A previously published method has been modified and simplified (instead of two-step sample preparation a single step extraction procedure was employed) which makes the new method timesaving. Nimesulide plasma concentrations were analyzed after single-step extraction with dichloromethane. The sample preparation procedure described enables efficient extraction - recoveries were 99 +/- 8% (mean +/- SD). Chromatography was performed on silica gel 60 F-254 TLC plates, developed with toluene-acetone, 100 + 10 (nu/nu) and evaluated densitometricatly at lambda = 310 nin in reflectance-absorbance mode. The R-F was 0.5025. The method presented is characterized by high sensitivity (0.1 mg L-1) and within-run and day-to-day coefficients of variation of 2.8-4.5% and 4.8-8.5%, respectively. The method was used t...o determine the pharmacokinetic profile of nimesulide in healthy volunteers after oral administration.

Izvor:
Journal of Planar Chromatography - Modern TLC, 2003, 16, 3, 211-213
Izdavač:
  • Research Inst Medicinal Plants, Budakalasz

DOI: 10.1556/JPC.16.2003.3.8

ISSN: 0933-4173

WoS: 000183923100008

Scopus: 2-s2.0-0038489377
[ Google Scholar ]
6
6
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/419
Kolekcije
  • Radovi istraživača / Researchers’ publications
Institucija
Pharmacy

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