Pharmacokinetic evaluation of a sustained release preparation of theophylline in asthmatic children and adults
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A sustained release preparation of theophylline (SRP of Th) was evaluated pharmacokinetically in asthmatic children and adults and it was found to have good SR properties. Different dosage requirements for equal pharmacokinetic behaviour in these two groups have been explained by the influence of the factors which can be responsible, such as bioavailability, liver mass and free drug concentration.
Source:Drug Development and Industrial Pharmacy, 1988, 14, 15-17, 2567-2577
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