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Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis

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2022
Joint_impact_of_pub_2022.pdf (1.411Mb)
Authors
Antonijević-Miljaković, Evica
Buha-Đorđević, Aleksandra
Bulat, Zorica
Antonijević, Biljana
Ćurčić, Marijana
Article (Published version)
Metadata
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Abstract
Considering that some researchers point to a possible influence of air pollution on COVID-19 transmission, severity, and death rate, the aim of our in silico study was to determine the relationship between the key air pollutants [sulphur dioxide (SO2), carbon monoxide (CO), particulate matter (PMx), nitrogen dioxide (NO2), and ozone (O3)] and COVID-19 complications using the publicly available toxicogenomic analytical and prediction tools: (i) Comparative Toxicogenomic Database (CTD) to identify genes common to air pollutants and COVID-19 complications; (ii) GeneMANIA to construct a network of these common and related genes; (iii) ToppGene Suite to extract the most important biological processes and molecular pathways; and (iv) DisGeNET to search for the top gene-disease pairs. SO2, CO, PMx, NO2 , and O 3 interacted with 6, 6, 18, 9, and 12 COVID-19-related genes, respectively. Four of these are common for all pollutants (IL10, IL6, IL1B, and TNF) and participate in most (77.64 %) phys...ical interactions. Further analysis pointed to cytokine binding and cytokine-mediated signalling pathway as the most important molecular function and biological process, respectively. Other molecular functions and biological processes are mostly related to cytokine activity and inflammation, which might be connected to the cytokine storm and resulting COVID-19 complications. The final step singled out the link between the CEBPA gene and acute myelocytic leukaemia and between TNFRSF1A and TNF receptor-associated periodic fever syndrome. This indicates possible complications in COVID-19 patients suffering from these diseases, especially those living in urban areas with poor air quality.

Keywords:
cytokines / carbon monoxide / disease complications / in silico / nitrogen dioxide / ozone / particulate matter / SARS-CoV-2 / sulphur dioxide
Source:
Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 2022, 73, 2, 119-125
Publisher:
  • Sciendo
Funding / projects:
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200161 (University of Belgrade, Faculty of Pharmacy) (RS-200161)

DOI: 10.2478/aiht-2022-73-3631

ISSN: 0004-1254

WoS: 000821226500003

Scopus: 2-s2.0-85134244676
[ Google Scholar ]
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/4201
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Ćurčić, Marijana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4201
AB  - Considering that some researchers point to a possible influence of air pollution on COVID-19 transmission, severity, and death rate, the aim of our in silico study was to determine the relationship between the key air pollutants [sulphur dioxide (SO2), carbon monoxide (CO), particulate matter (PMx), nitrogen dioxide (NO2), and ozone (O3)] and COVID-19 complications using the publicly available toxicogenomic analytical and prediction tools: (i) Comparative Toxicogenomic Database (CTD) to identify genes common to air pollutants and COVID-19 complications; (ii) GeneMANIA to construct a network of these common and related genes; (iii) ToppGene Suite to extract the most important biological processes and molecular pathways; and (iv) DisGeNET to search for the top gene-disease pairs. SO2, CO, PMx, NO2 , and O 3 interacted with 6, 6, 18, 9, and 12 COVID-19-related genes, respectively. Four of these are common for all pollutants (IL10, IL6, IL1B, and TNF) and participate in most (77.64 %) physical interactions. Further analysis pointed to cytokine binding and cytokine-mediated signalling pathway as the most important molecular function and biological process, respectively. Other molecular functions and biological processes are mostly related to cytokine activity and inflammation, which might be connected to the cytokine storm and resulting COVID-19 complications. The final step singled out the link between the CEBPA gene and acute myelocytic leukaemia and between TNFRSF1A and TNF receptor-associated periodic fever syndrome. This indicates possible complications in COVID-19 patients suffering from these diseases, especially those living in urban areas with poor air quality.
PB  - Sciendo
T2  - Arhiv za Higijenu Rada i Toksikologiju
T1  - Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis
VL  - 73
IS  - 2
SP  - 119
EP  - 125
DO  - 10.2478/aiht-2022-73-3631
ER  - 
@article{
author = "Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Ćurčić, Marijana",
year = "2022",
abstract = "Considering that some researchers point to a possible influence of air pollution on COVID-19 transmission, severity, and death rate, the aim of our in silico study was to determine the relationship between the key air pollutants [sulphur dioxide (SO2), carbon monoxide (CO), particulate matter (PMx), nitrogen dioxide (NO2), and ozone (O3)] and COVID-19 complications using the publicly available toxicogenomic analytical and prediction tools: (i) Comparative Toxicogenomic Database (CTD) to identify genes common to air pollutants and COVID-19 complications; (ii) GeneMANIA to construct a network of these common and related genes; (iii) ToppGene Suite to extract the most important biological processes and molecular pathways; and (iv) DisGeNET to search for the top gene-disease pairs. SO2, CO, PMx, NO2 , and O 3 interacted with 6, 6, 18, 9, and 12 COVID-19-related genes, respectively. Four of these are common for all pollutants (IL10, IL6, IL1B, and TNF) and participate in most (77.64 %) physical interactions. Further analysis pointed to cytokine binding and cytokine-mediated signalling pathway as the most important molecular function and biological process, respectively. Other molecular functions and biological processes are mostly related to cytokine activity and inflammation, which might be connected to the cytokine storm and resulting COVID-19 complications. The final step singled out the link between the CEBPA gene and acute myelocytic leukaemia and between TNFRSF1A and TNF receptor-associated periodic fever syndrome. This indicates possible complications in COVID-19 patients suffering from these diseases, especially those living in urban areas with poor air quality.",
publisher = "Sciendo",
journal = "Arhiv za Higijenu Rada i Toksikologiju",
title = "Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis",
volume = "73",
number = "2",
pages = "119-125",
doi = "10.2478/aiht-2022-73-3631"
}
Antonijević-Miljaković, E., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Ćurčić, M.. (2022). Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis. in Arhiv za Higijenu Rada i Toksikologiju
Sciendo., 73(2), 119-125.
https://doi.org/10.2478/aiht-2022-73-3631
Antonijević-Miljaković E, Buha-Đorđević A, Bulat Z, Antonijević B, Ćurčić M. Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis. in Arhiv za Higijenu Rada i Toksikologiju. 2022;73(2):119-125.
doi:10.2478/aiht-2022-73-3631 .
Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Ćurčić, Marijana, "Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis" in Arhiv za Higijenu Rada i Toksikologiju, 73, no. 2 (2022):119-125,
https://doi.org/10.2478/aiht-2022-73-3631 . .

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