The chromatographic behavior of some beta-adrenoceptor antagonists has been studied by RP HPTLC on C-18 with water-acetonitrile (phi = 0.2-0.7) and water-dioxane (phi = 0.1-0.5) mobile phases. The retention mechanism was investigated and retention constants, R-M(0) were determined by extrapolation. Good correlation was obtained between R-M(0) and the slope, m, of chromatographic equations. These retention constants correlated well with log P of beta-adrenoceptor antagonists and can be used as a measure of the lipophilicity of the compounds investigated.
Keywords:
beta-adrenoceptor antagonists / R-M(0) / log P
Source:
Journal of Planar Chromatography - Modern TLC, 2003, 16, 5, 347-350
Publisher:
Springer Nature
Funding / projects:
Project “Molecular Structures,
Chemical Transformations, Physicochemical Characterization,
Pharmaceutical Purity, and Analysis of Pharmacologically
Active Compounds, No. 1458)” which is partly financial supported by the Serbian Ministry of Science and Technology.
TY - JOUR
AU - Perišić-Janjić, Nada U.
AU - Lučić, Branka
AU - Janjić, Nataša J.
AU - Agbaba, Danica
PY - 2003
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/424
AB - The chromatographic behavior of some beta-adrenoceptor antagonists has been studied by RP HPTLC on C-18 with water-acetonitrile (phi = 0.2-0.7) and water-dioxane (phi = 0.1-0.5) mobile phases. The retention mechanism was investigated and retention constants, R-M(0) were determined by extrapolation. Good correlation was obtained between R-M(0) and the slope, m, of chromatographic equations. These retention constants correlated well with log P of beta-adrenoceptor antagonists and can be used as a measure of the lipophilicity of the compounds investigated.
PB - Springer Nature
T2 - Journal of Planar Chromatography - Modern TLC
T1 - Study of the lipophilicity and retention behavior of some beta-adrenoceptor antagonists
VL - 16
IS - 5
SP - 347
EP - 350
DO - 10.1556/JPC.16.2003.5.3
ER -
@article{
author = "Perišić-Janjić, Nada U. and Lučić, Branka and Janjić, Nataša J. and Agbaba, Danica",
year = "2003",
abstract = "The chromatographic behavior of some beta-adrenoceptor antagonists has been studied by RP HPTLC on C-18 with water-acetonitrile (phi = 0.2-0.7) and water-dioxane (phi = 0.1-0.5) mobile phases. The retention mechanism was investigated and retention constants, R-M(0) were determined by extrapolation. Good correlation was obtained between R-M(0) and the slope, m, of chromatographic equations. These retention constants correlated well with log P of beta-adrenoceptor antagonists and can be used as a measure of the lipophilicity of the compounds investigated.",
publisher = "Springer Nature",
journal = "Journal of Planar Chromatography - Modern TLC",
title = "Study of the lipophilicity and retention behavior of some beta-adrenoceptor antagonists",
volume = "16",
number = "5",
pages = "347-350",
doi = "10.1556/JPC.16.2003.5.3"
}
Perišić-Janjić, N. U., Lučić, B., Janjić, N. J.,& Agbaba, D.. (2003). Study of the lipophilicity and retention behavior of some beta-adrenoceptor antagonists. in Journal of Planar Chromatography - Modern TLC
Springer Nature., 16(5), 347-350.
https://doi.org/10.1556/JPC.16.2003.5.3
Perišić-Janjić NU, Lučić B, Janjić NJ, Agbaba D. Study of the lipophilicity and retention behavior of some beta-adrenoceptor antagonists. in Journal of Planar Chromatography - Modern TLC. 2003;16(5):347-350.
doi:10.1556/JPC.16.2003.5.3 .
Perišić-Janjić, Nada U., Lučić, Branka, Janjić, Nataša J., Agbaba, Danica, "Study of the lipophilicity and retention behavior of some beta-adrenoceptor antagonists" in Journal of Planar Chromatography - Modern TLC, 16, no. 5 (2003):347-350,
https://doi.org/10.1556/JPC.16.2003.5.3 . .
