Study of the lipophilicity and retention behavior of some beta-adrenoceptor antagonists
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The chromatographic behavior of some beta-adrenoceptor antagonists has been studied by RP HPTLC on C-18 with water-acetonitrile (phi = 0.2-0.7) and water-dioxane (phi = 0.1-0.5) mobile phases. The retention mechanism was investigated and retention constants, R-M(0) were determined by extrapolation. Good correlation was obtained between R-M(0) and the slope, m, of chromatographic equations. These retention constants correlated well with log P of beta-adrenoceptor antagonists and can be used as a measure of the lipophilicity of the compounds investigated.
Keywords:beta-adrenoceptor antagonists / R-M(0) / log P
Source:Journal of Planar Chromatography - Modern TLC, 2003, 16, 5, 347-350
- Research Inst Medicinal Plants, Budakalasz