Study of the lipophilicity and retention behavior of some beta-adrenoceptor antagonists
Samo za registrovane korisnike
2003
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The chromatographic behavior of some beta-adrenoceptor antagonists has been studied by RP HPTLC on C-18 with water-acetonitrile (phi = 0.2-0.7) and water-dioxane (phi = 0.1-0.5) mobile phases. The retention mechanism was investigated and retention constants, R-M(0) were determined by extrapolation. Good correlation was obtained between R-M(0) and the slope, m, of chromatographic equations. These retention constants correlated well with log P of beta-adrenoceptor antagonists and can be used as a measure of the lipophilicity of the compounds investigated.
Ključne reči:
beta-adrenoceptor antagonists / R-M(0) / log PIzvor:
Journal of Planar Chromatography - Modern TLC, 2003, 16, 5, 347-350Izdavač:
- Springer Nature
Finansiranje / projekti:
- Project “Molecular Structures, Chemical Transformations, Physicochemical Characterization, Pharmaceutical Purity, and Analysis of Pharmacologically Active Compounds, No. 1458)” which is partly financial supported by the Serbian Ministry of Science and Technology.
DOI: 10.1556/JPC.16.2003.5.3
ISSN: 0933-4173
WoS: 000187571700003
Scopus: 2-s2.0-17944399854
Institucija/grupa
PharmacyTY - JOUR AU - Perišić-Janjić, Nada U. AU - Lučić, Branka AU - Janjić, Nataša J. AU - Agbaba, Danica PY - 2003 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/424 AB - The chromatographic behavior of some beta-adrenoceptor antagonists has been studied by RP HPTLC on C-18 with water-acetonitrile (phi = 0.2-0.7) and water-dioxane (phi = 0.1-0.5) mobile phases. The retention mechanism was investigated and retention constants, R-M(0) were determined by extrapolation. Good correlation was obtained between R-M(0) and the slope, m, of chromatographic equations. These retention constants correlated well with log P of beta-adrenoceptor antagonists and can be used as a measure of the lipophilicity of the compounds investigated. PB - Springer Nature T2 - Journal of Planar Chromatography - Modern TLC T1 - Study of the lipophilicity and retention behavior of some beta-adrenoceptor antagonists VL - 16 IS - 5 SP - 347 EP - 350 DO - 10.1556/JPC.16.2003.5.3 ER -
@article{ author = "Perišić-Janjić, Nada U. and Lučić, Branka and Janjić, Nataša J. and Agbaba, Danica", year = "2003", abstract = "The chromatographic behavior of some beta-adrenoceptor antagonists has been studied by RP HPTLC on C-18 with water-acetonitrile (phi = 0.2-0.7) and water-dioxane (phi = 0.1-0.5) mobile phases. The retention mechanism was investigated and retention constants, R-M(0) were determined by extrapolation. Good correlation was obtained between R-M(0) and the slope, m, of chromatographic equations. These retention constants correlated well with log P of beta-adrenoceptor antagonists and can be used as a measure of the lipophilicity of the compounds investigated.", publisher = "Springer Nature", journal = "Journal of Planar Chromatography - Modern TLC", title = "Study of the lipophilicity and retention behavior of some beta-adrenoceptor antagonists", volume = "16", number = "5", pages = "347-350", doi = "10.1556/JPC.16.2003.5.3" }
Perišić-Janjić, N. U., Lučić, B., Janjić, N. J.,& Agbaba, D.. (2003). Study of the lipophilicity and retention behavior of some beta-adrenoceptor antagonists. in Journal of Planar Chromatography - Modern TLC Springer Nature., 16(5), 347-350. https://doi.org/10.1556/JPC.16.2003.5.3
Perišić-Janjić NU, Lučić B, Janjić NJ, Agbaba D. Study of the lipophilicity and retention behavior of some beta-adrenoceptor antagonists. in Journal of Planar Chromatography - Modern TLC. 2003;16(5):347-350. doi:10.1556/JPC.16.2003.5.3 .
Perišić-Janjić, Nada U., Lučić, Branka, Janjić, Nataša J., Agbaba, Danica, "Study of the lipophilicity and retention behavior of some beta-adrenoceptor antagonists" in Journal of Planar Chromatography - Modern TLC, 16, no. 5 (2003):347-350, https://doi.org/10.1556/JPC.16.2003.5.3 . .