The treatment of respiratory infections in children requires special attention, since the
paediatric population has rather specific characteristics and consists of heterogenous subgroups.
In this context, the choice of a suitable drug dosage form is of particular importance, depending
on the active substance properties, along with the age and general condition of a paediatric patient.
Тhe most commonly used pharmaceutical products for respiratory infections in children include
oral, parenteral and inhalation dosage forms, although a large number of drugs are not available
in a suitable dosage form and/or strength for paediatric age, leading to the frequent use of
unauthorized drugs (i.e., unlicensed use). Other important issues that should be considered when
choosing the appropriate paediatric dosage form and/or compounding procedure are related to the
careful considerations of the pharmaceutical product composition (safety of excipients) and the
choice of administration/dosi...ng device in relation to a child’s age.
This paper provides an overview of paediatric dosage forms used in the treatment of
respiratory infections in children, their benefits and limitations. The review includes examples of
various pharmaceutical products, along with the considerations regarding administration/dosing
devices. Specific characteristics of paediatric populations affecting the decision on the choice of
age-appropriate paediatric formulation are also addressed.
Terapija respiratornih infekcija kod dece zahteva posebnu pažnju, jer ovu populaciju čini specifična i izuzetno heterogena grupa pacijenata. Veoma je važno odabrati odgovarajući farmaceutski oblik leka, u skladu sa karakteristikama aktivne supstance, kao i stanjem i uzrastom deteta. U praksi se, u terapiji respiratornih infekcija kod dece, najviše koriste preparati za oralnu primenu, za parenteralnu primenu i za inhalaciju. Međutim, veliki broj lekova nije dostupan u odgovarajućem farmaceutskom obliku i/ili jačini za pedijatrijski uzrast, usled čega je česta neodobrena upotreba lekova. Prilikom izbora/izrade preparata za decu potrebno je pažljivo razmotriti i sastav preparata (bezbednost pomoćnih supstanci), kao i izbor aplikatora, u skladu sa uzrastom deteta. U ovom radu je dat prikaz farmaceutskih oblika lekova koji se koriste u terapiji respiratornih infekcija kod dece, njihovih prednosti i izvesnih nedostataka. Navedeni su različiti primeri farmaceutskih preparata, uz poseban osvrt... na izbor aplikatora za primenu/doziranje lekova. Takođe, diskutovane su specifičnosti pedijatrijske populacije koje utiču na izbor odgovarajuće formulacije leka prilagođene uzrastu deteta.
Keywords:
Paediatric dosage forms / age-appropriate formulation / extemporaneous compounding / administration/dosing devices / respiratory infections / farmaceutski oblici lekova za decu / lekovi prilagođeni pedijatrijskom uzrastu / izrada magistralnih lekova / aplikatori za primenu/doziranje lekova / respiratorne infekcije
TY - JOUR
AU - Cvijić, Sandra
AU - Mirković, Dušica
AU - Krajišnik, Danina
PY - 2022
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4260
AB - The treatment of respiratory infections in children requires special attention, since the
paediatric population has rather specific characteristics and consists of heterogenous subgroups.
In this context, the choice of a suitable drug dosage form is of particular importance, depending
on the active substance properties, along with the age and general condition of a paediatric patient.
Тhe most commonly used pharmaceutical products for respiratory infections in children include
oral, parenteral and inhalation dosage forms, although a large number of drugs are not available
in a suitable dosage form and/or strength for paediatric age, leading to the frequent use of
unauthorized drugs (i.e., unlicensed use). Other important issues that should be considered when
choosing the appropriate paediatric dosage form and/or compounding procedure are related to the
careful considerations of the pharmaceutical product composition (safety of excipients) and the
choice of administration/dosing device in relation to a child’s age.
This paper provides an overview of paediatric dosage forms used in the treatment of
respiratory infections in children, their benefits and limitations. The review includes examples of
various pharmaceutical products, along with the considerations regarding administration/dosing
devices. Specific characteristics of paediatric populations affecting the decision on the choice of
age-appropriate paediatric formulation are also addressed.
AB - Terapija respiratornih infekcija kod dece zahteva posebnu pažnju, jer ovu populaciju čini specifična i izuzetno heterogena grupa pacijenata. Veoma je važno odabrati odgovarajući farmaceutski oblik leka, u skladu sa karakteristikama aktivne supstance, kao i stanjem i uzrastom deteta. U praksi se, u terapiji respiratornih infekcija kod dece, najviše koriste preparati za oralnu primenu, za parenteralnu primenu i za inhalaciju. Međutim, veliki broj lekova nije dostupan u odgovarajućem farmaceutskom obliku i/ili jačini za pedijatrijski uzrast, usled čega je česta neodobrena upotreba lekova. Prilikom izbora/izrade preparata za decu potrebno je pažljivo razmotriti i sastav preparata (bezbednost pomoćnih supstanci), kao i izbor aplikatora, u skladu sa uzrastom deteta. U ovom radu je dat prikaz farmaceutskih oblika lekova koji se koriste u terapiji respiratornih infekcija kod dece, njihovih prednosti i izvesnih nedostataka. Navedeni su različiti primeri farmaceutskih preparata, uz poseban osvrt na izbor aplikatora za primenu/doziranje lekova. Takođe, diskutovane su specifičnosti pedijatrijske populacije koje utiču na izbor odgovarajuće formulacije leka prilagođene uzrastu deteta.
PB - Beograd : Savez farmaceutskih udruženja Srbije
T2 - Arhiv za farmaciju
T1 - How to choose an appropriate drug dosage form for the treatment of respiratory infections in children: Facts and tips
T1 - Stavovi i saveti vezani za izbor farmaceutskih oblika lekova za lečenje respiratornih infekcija kod dece
VL - 72
IS - 3
SP - 353
EP - 372
DO - 10.5937/arhfarm72-37643
ER -
@article{
author = "Cvijić, Sandra and Mirković, Dušica and Krajišnik, Danina",
year = "2022",
abstract = "The treatment of respiratory infections in children requires special attention, since the
paediatric population has rather specific characteristics and consists of heterogenous subgroups.
In this context, the choice of a suitable drug dosage form is of particular importance, depending
on the active substance properties, along with the age and general condition of a paediatric patient.
Тhe most commonly used pharmaceutical products for respiratory infections in children include
oral, parenteral and inhalation dosage forms, although a large number of drugs are not available
in a suitable dosage form and/or strength for paediatric age, leading to the frequent use of
unauthorized drugs (i.e., unlicensed use). Other important issues that should be considered when
choosing the appropriate paediatric dosage form and/or compounding procedure are related to the
careful considerations of the pharmaceutical product composition (safety of excipients) and the
choice of administration/dosing device in relation to a child’s age.
This paper provides an overview of paediatric dosage forms used in the treatment of
respiratory infections in children, their benefits and limitations. The review includes examples of
various pharmaceutical products, along with the considerations regarding administration/dosing
devices. Specific characteristics of paediatric populations affecting the decision on the choice of
age-appropriate paediatric formulation are also addressed., Terapija respiratornih infekcija kod dece zahteva posebnu pažnju, jer ovu populaciju čini specifična i izuzetno heterogena grupa pacijenata. Veoma je važno odabrati odgovarajući farmaceutski oblik leka, u skladu sa karakteristikama aktivne supstance, kao i stanjem i uzrastom deteta. U praksi se, u terapiji respiratornih infekcija kod dece, najviše koriste preparati za oralnu primenu, za parenteralnu primenu i za inhalaciju. Međutim, veliki broj lekova nije dostupan u odgovarajućem farmaceutskom obliku i/ili jačini za pedijatrijski uzrast, usled čega je česta neodobrena upotreba lekova. Prilikom izbora/izrade preparata za decu potrebno je pažljivo razmotriti i sastav preparata (bezbednost pomoćnih supstanci), kao i izbor aplikatora, u skladu sa uzrastom deteta. U ovom radu je dat prikaz farmaceutskih oblika lekova koji se koriste u terapiji respiratornih infekcija kod dece, njihovih prednosti i izvesnih nedostataka. Navedeni su različiti primeri farmaceutskih preparata, uz poseban osvrt na izbor aplikatora za primenu/doziranje lekova. Takođe, diskutovane su specifičnosti pedijatrijske populacije koje utiču na izbor odgovarajuće formulacije leka prilagođene uzrastu deteta.",
publisher = "Beograd : Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "How to choose an appropriate drug dosage form for the treatment of respiratory infections in children: Facts and tips, Stavovi i saveti vezani za izbor farmaceutskih oblika lekova za lečenje respiratornih infekcija kod dece",
volume = "72",
number = "3",
pages = "353-372",
doi = "10.5937/arhfarm72-37643"
}
Cvijić, S., Mirković, D.,& Krajišnik, D.. (2022). How to choose an appropriate drug dosage form for the treatment of respiratory infections in children: Facts and tips. in Arhiv za farmaciju
Beograd : Savez farmaceutskih udruženja Srbije., 72(3), 353-372.
https://doi.org/10.5937/arhfarm72-37643
Cvijić S, Mirković D, Krajišnik D. How to choose an appropriate drug dosage form for the treatment of respiratory infections in children: Facts and tips. in Arhiv za farmaciju. 2022;72(3):353-372.
doi:10.5937/arhfarm72-37643 .
Cvijić, Sandra, Mirković, Dušica, Krajišnik, Danina, "How to choose an appropriate drug dosage form for the treatment of respiratory infections in children: Facts and tips" in Arhiv za farmaciju, 72, no. 3 (2022):353-372,
https://doi.org/10.5937/arhfarm72-37643 . .
