Приказ основних података о документу

dc.creatorĐoković, Jelena
dc.creatorDemisli, Sotiria
dc.creatorSavić, Sanela
dc.creatorMarković, Bojan
dc.creatorCekić, Nebojša D.
dc.creatorRanđelović, Danijela V.
dc.creatorMitrović, Jelena
dc.creatorLunter, Dominique Jasmin
dc.creatorPapadimitriou, Vassiliki
dc.creatorXenakis, Aristotelis
dc.creatorSavić, Snežana
dc.date.accessioned2022-09-21T09:26:40Z
dc.date.available2022-09-21T09:26:40Z
dc.date.issued2022
dc.identifier.issn1999-4923
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/4265
dc.description.abstractA nanotechnology-based approach to drug delivery presents one of the biggest trends in biomedical science that can provide increased active concentration, bioavailability, and safety compared to conventional drug-delivery systems. Nanoemulsions stand out amongst other nanocarriers for being biodegradable, biocompatible, and relatively easy to manufacture. For improved drug-delivery properties, longer circulation for the nanoemulsion droplets should be provided, to allow the active to reach the target site. One of the strategies used for this purpose is PEGylation. The aim of this research was assessing the impact of the oil phase selection, soybean or fish oil mixtures with medium chain triglycerides, on the physicochemical characteristics and injectability of curcumin-loaded PEGylated nanoemulsions. Electron paramagnetic resonance spectroscopy demonstrated the structural impact of the oil phase on the stabilizing layer of nanoemulsions, with a more pronounced stabilizing effect of curcumin observed in the fish oil nanoemulsion compared to the soybean oil one. The design of the experiment study, employed to simultaneously assess the impact of the oil phase, different PEGylated phospholipids and their concentrations, as well as the presence of curcumin, showed that not only the investigated factors alone, but also their interactions, had a significant influence on the critical quality attributes of the PEGylated nanoemulsions. Detailed physicochemical characterization of the NEs found all formulations were appropriate for parenteral administration and remained stable during two years of storage, with the preserved antioxidant activity demonstrated by DPPH and FRAP assays. In vitro release studies showed a more pronounced release of curcumin from the fish oil NEs compared to that from the soybean oil ones. The innovative in vitro injectability assessment, designed to mimic intravenous application, proved that all formulations tested in selected experimental setting could be employed in prospective in vivo studies. Overall, the current study shows the importance of oil phase selection when formulating PEGylated nanoemulsionssr
dc.language.isoensr
dc.publisherMDPIsr
dc.relationinfo:eu-repo/grantAgreement/ScienceFundRS/Ideje/7749108/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200026/RS//sr
dc.rightsopenAccesssr
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcePharmaceuticssr
dc.subjectCurcuminsr
dc.subjectPEGylated nanoemulsionssr
dc.subjectelectron paramagnetic resonance spectroscopysr
dc.subjectD-optimal experimental designsr
dc.subjectfish oilsr
dc.subjectinjectabilitysr
dc.titleThe Impact of the Oil Phase Selection on Physicochemical Properties, Long-Term Stability, In Vitro Performance and Injectability of Curcumin-Loaded PEGylated Nanoemulsionssr
dc.typearticlesr
dc.rights.licenseBYsr
dc.citation.volume14
dc.citation.issue8
dc.citation.rankM21
dc.identifier.wos000845739800001
dc.identifier.doi10.3390/pharmaceutics14081666
dc.identifier.scopus2-s2.0-85137414071
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/10357/The_Impact_of_pub_2022.pdf
dc.type.versionpublishedVersionsr


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу