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Formulation and characterization of immediate-release oral dosage forms with zolpidem tartrate fabricated by digital light processing (DLP) 3D printing technique

Authorized Users Only
2022
Authors
Adamov, Ivana
Stanojević, Gordana
Medarević, Đorđe
Ivković, Branka
Kočović, David
Mirković, Dušica
Ibrić, Svetlana
Article (Published version)
Metadata
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Abstract
The introduction of three-dimensional (3D) printing in the pharmaceutical field has made great strides towards innovations in the way drugs are designed and manufactured. In this study, digital light processing (DLP) technique was used to fabricate oral dosage forms of different shapes with zolpidem tartrate (ZT), incorporated within its therapeutic range. Formulation factors, such as poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) 400 (PEG 400) ratio, as well as water content, were varied in combination with the surface area/volume (SA/V) ratio to achieve immediate drug release. Hypromellose (HPMC) was used as a stabilizing agent of photoreactive suspensions in an attempt to prevent drug sedimentation and subsequent variations in drug content uniformity. Oral dosage forms with doses in the range from 0.15 mg to 6.37 mg, showing very rapid and rapid drug dissolution, were successfully fabricated, confirming the potential of this technique in drug manufacturing with t...he ability to provide flexible dose adjustments and desirable release profiles by varying formulation factors and geometry of 3D models. DSC (differential scanning calorimetry), XRPD (X-ray powder diffraction) and scanning electron microscopy (SEM) showed that ZT remained in a crystalline form within printed dosage forms and no interactions were found between ZT and polymers.

Keywords:
digital light processing (DLP) / Drug release rate / formulation factors, surface area/volume (SA/V) ratio / Individualization of therapy / three-dimensional (3D) printing
Source:
International journal of pharmaceutics, 2022, 624
Publisher:
  • Elsevier
Funding / projects:
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200161 (University of Belgrade, Faculty of Pharmacy) (RS-200161)

DOI: 10.1016/j.ijpharm.2022.122046

ISSN: 0378-5173

Scopus: 2-s2.0-85136340080
[ Google Scholar ]
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/4275
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Adamov, Ivana
AU  - Stanojević, Gordana
AU  - Medarević, Đorđe
AU  - Ivković, Branka
AU  - Kočović, David
AU  - Mirković, Dušica
AU  - Ibrić, Svetlana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4275
AB  - The introduction of three-dimensional (3D) printing in the pharmaceutical field has made great strides towards innovations in the way drugs are designed and manufactured. In this study, digital light processing (DLP) technique was used to fabricate oral dosage forms of different shapes with zolpidem tartrate (ZT), incorporated within its therapeutic range. Formulation factors, such as poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) 400 (PEG 400) ratio, as well as water content, were varied in combination with the surface area/volume (SA/V) ratio to achieve immediate drug release. Hypromellose (HPMC) was used as a stabilizing agent of photoreactive suspensions in an attempt to prevent drug sedimentation and subsequent variations in drug content uniformity. Oral dosage forms with doses in the range from 0.15 mg to 6.37 mg, showing very rapid and rapid drug dissolution, were successfully fabricated, confirming the potential of this technique in drug manufacturing with the ability to provide flexible dose adjustments and desirable release profiles by varying formulation factors and geometry of 3D models. DSC (differential scanning calorimetry), XRPD (X-ray powder diffraction) and scanning electron microscopy (SEM) showed that ZT remained in a crystalline form within printed dosage forms and no interactions were found between ZT and polymers.
PB  - Elsevier
T2  - International journal of pharmaceutics
T1  - Formulation and characterization of immediate-release oral dosage forms with zolpidem tartrate fabricated by digital light processing (DLP) 3D printing technique
VL  - 624
DO  - 10.1016/j.ijpharm.2022.122046
ER  - 
@article{
author = "Adamov, Ivana and Stanojević, Gordana and Medarević, Đorđe and Ivković, Branka and Kočović, David and Mirković, Dušica and Ibrić, Svetlana",
year = "2022",
abstract = "The introduction of three-dimensional (3D) printing in the pharmaceutical field has made great strides towards innovations in the way drugs are designed and manufactured. In this study, digital light processing (DLP) technique was used to fabricate oral dosage forms of different shapes with zolpidem tartrate (ZT), incorporated within its therapeutic range. Formulation factors, such as poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) 400 (PEG 400) ratio, as well as water content, were varied in combination with the surface area/volume (SA/V) ratio to achieve immediate drug release. Hypromellose (HPMC) was used as a stabilizing agent of photoreactive suspensions in an attempt to prevent drug sedimentation and subsequent variations in drug content uniformity. Oral dosage forms with doses in the range from 0.15 mg to 6.37 mg, showing very rapid and rapid drug dissolution, were successfully fabricated, confirming the potential of this technique in drug manufacturing with the ability to provide flexible dose adjustments and desirable release profiles by varying formulation factors and geometry of 3D models. DSC (differential scanning calorimetry), XRPD (X-ray powder diffraction) and scanning electron microscopy (SEM) showed that ZT remained in a crystalline form within printed dosage forms and no interactions were found between ZT and polymers.",
publisher = "Elsevier",
journal = "International journal of pharmaceutics",
title = "Formulation and characterization of immediate-release oral dosage forms with zolpidem tartrate fabricated by digital light processing (DLP) 3D printing technique",
volume = "624",
doi = "10.1016/j.ijpharm.2022.122046"
}
Adamov, I., Stanojević, G., Medarević, Đ., Ivković, B., Kočović, D., Mirković, D.,& Ibrić, S.. (2022). Formulation and characterization of immediate-release oral dosage forms with zolpidem tartrate fabricated by digital light processing (DLP) 3D printing technique. in International journal of pharmaceutics
Elsevier., 624.
https://doi.org/10.1016/j.ijpharm.2022.122046
Adamov I, Stanojević G, Medarević Đ, Ivković B, Kočović D, Mirković D, Ibrić S. Formulation and characterization of immediate-release oral dosage forms with zolpidem tartrate fabricated by digital light processing (DLP) 3D printing technique. in International journal of pharmaceutics. 2022;624.
doi:10.1016/j.ijpharm.2022.122046 .
Adamov, Ivana, Stanojević, Gordana, Medarević, Đorđe, Ivković, Branka, Kočović, David, Mirković, Dušica, Ibrić, Svetlana, "Formulation and characterization of immediate-release oral dosage forms with zolpidem tartrate fabricated by digital light processing (DLP) 3D printing technique" in International journal of pharmaceutics, 624 (2022),
https://doi.org/10.1016/j.ijpharm.2022.122046 . .

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