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dc.creatorAdamov, Ivana
dc.creatorStanojević, Gordana
dc.creatorMedarević, Đorđe
dc.creatorIvković, Branka
dc.creatorKočović, David
dc.creatorMirković, Dušica
dc.creatorIbrić, Svetlana
dc.date.accessioned2022-09-29T08:12:59Z
dc.date.available2022-09-29T08:12:59Z
dc.date.issued2022
dc.identifier.issn0378-5173
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/4275
dc.description.abstractThe introduction of three-dimensional (3D) printing in the pharmaceutical field has made great strides towards innovations in the way drugs are designed and manufactured. In this study, digital light processing (DLP) technique was used to fabricate oral dosage forms of different shapes with zolpidem tartrate (ZT), incorporated within its therapeutic range. Formulation factors, such as poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) 400 (PEG 400) ratio, as well as water content, were varied in combination with the surface area/volume (SA/V) ratio to achieve immediate drug release. Hypromellose (HPMC) was used as a stabilizing agent of photoreactive suspensions in an attempt to prevent drug sedimentation and subsequent variations in drug content uniformity. Oral dosage forms with doses in the range from 0.15 mg to 6.37 mg, showing very rapid and rapid drug dissolution, were successfully fabricated, confirming the potential of this technique in drug manufacturing with the ability to provide flexible dose adjustments and desirable release profiles by varying formulation factors and geometry of 3D models. DSC (differential scanning calorimetry), XRPD (X-ray powder diffraction) and scanning electron microscopy (SEM) showed that ZT remained in a crystalline form within printed dosage forms and no interactions were found between ZT and polymers.
dc.publisherElsevier
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//
dc.rightsrestrictedAccess
dc.sourceInternational journal of pharmaceutics
dc.subjectdigital light processing (DLP)
dc.subjectDrug release rate
dc.subjectformulation factors, surface area/volume (SA/V) ratio
dc.subjectIndividualization of therapy
dc.subjectthree-dimensional (3D) printing
dc.titleFormulation and characterization of immediate-release oral dosage forms with zolpidem tartrate fabricated by digital light processing (DLP) 3D printing technique
dc.typearticle
dc.rights.licenseARR
dc.citation.volume624
dc.citation.rankM21
dc.identifier.wos000879195600009
dc.identifier.doi10.1016/j.ijpharm.2022.122046
dc.identifier.scopus2-s2.0-85136340080
dc.type.versionpublishedVersion


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