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Prevalence of potentially inappropriate prescribing in older adults in Central and Eastern Europe: a systematic review and synthesis without meta-analysis
dc.creator | Brkić, Jovana | |
dc.creator | Fialova, Daniela | |
dc.creator | Okuyan, Betul | |
dc.creator | Kummer, Ingrid | |
dc.creator | Šesto, Sofija | |
dc.creator | Capiau, Andreas | |
dc.creator | Ortner Hadžiabdić, Maja | |
dc.creator | Tachkov, Konstantin | |
dc.creator | Bobrova, Veera | |
dc.date.accessioned | 2022-10-18T13:17:04Z | |
dc.date.available | 2022-10-18T13:17:04Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/4286 | |
dc.description.abstract | We aimed to systematically review the prevalence of potentially inappropriate prescribing (PIP) in older adults in Central and Eastern Europe (CEE) in all care settings. We searched Embase and MEDLINE (up to June 2019) and checked the reference lists of the included studies and relevant reviews. Eligible studies used validated explicit or implicit tools to assess the PIP prevalence in older adults in CEE. All study designs were considered, except case‒control studies and case series. We assessed the risk of bias using the Joanna Briggs Institute Prevalence Critical Appraisal Tool and the certainty of evidence using the GRADE approach. Meta-analysis was inappropriate due to heterogeneity in the outcome measurements. Therefore, we used the synthesis without meta-analysis approach—summarizing effect estimates method. This review included twenty-seven studies with 139,693 participants. Most studies were cross-sectional and conducted in high-income countries. The data synthesis across 26 studies revealed the PIP prevalence: the median was 34.6%, the interquartile range was 25.9–63.2%, and the range was 6.5–95.8%. The certainty of this evidence was very low due to the risk of bias, imprecision, and inconsistency. These findings show that PIP is a prevalent issue in the CEE region. Further well-designed studies conducted across countries are needed to strengthen the existing evidence and increase the generalizability of findings. | |
dc.publisher | Nature Research | |
dc.relation | EuroAgeism project, grant number 764632. | |
dc.relation | Ministry of Education, Youth and Sports of the Czech Republic, Czech Operational Programme Research, Development and Education, Pre-application research into innovative medicines and medical technologies (InoMed) project, grant number CZ.02.1.01/0.0/0.0/18_069/0010046; | |
dc.relation | Charles University project, grant number: SVV 260 551 | |
dc.relation | Charles University project, Research program Cooperatio, research unit KSKF-I Ageing, Polypharmacy and Changes in the Therapeutic value of Drugs in the AgeD (Chair: Assoc. Prof. Daniela Fialova); Ministry of Education, Youth and Sports of the Czech Republic, Czech Operational Programme Research, Development and Education, START Programme, grant number: CZ.02.2.69/0.0/0.0/19_073/0016935; | |
dc.relation | European Union’s Horizon 2020 research and innovation programme I-CARE4OLD project, grant number 965341 | |
dc.relation.isreferencedby | https://farfar.pharmacy.bg.ac.rs/handle/123456789/4345 | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scientific Reports | |
dc.title | Prevalence of potentially inappropriate prescribing in older adults in Central and Eastern Europe: a systematic review and synthesis without meta-analysis | |
dc.type | article | |
dc.rights.license | BY | |
dc.citation.volume | 12 | |
dc.citation.issue | 1 | |
dc.citation.rank | M21 | |
dc.description.other | This article has been corrected. Link to the correction: [https://farfar.pharmacy.bg.ac.rs/handle/123456789/4345] | |
dc.identifier.wos | 000864845400058 | |
dc.identifier.doi | 10.1038/s41598-022-19860-8 | |
dc.identifier.scopus | 2-s2.0-85139294846 | |
dc.identifier.fulltext | http://farfar.pharmacy.bg.ac.rs/bitstream/id/10456/Prevalence_of_potentially_pub_2022.pdf | |
dc.type.version | publishedVersion |