First-order UV-derivative spectrophotometry in the analysis of omeprazole and pantoprazole sodium salt and corresponding impurities
Само за регистроване кориснике
2003
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The first-order UV-derivative spectrophotometry, applying zero-crossing method was developed for the determination of omeprazole (OM), omeprazole sulphone (OMS), pantoprazole sodium salt (PANa), and N-methylpantoprazole (NPA) in methanol-ammonia 4.0% v/v, where the sufficient spectra resolutions of drug and corresponding impurity were obtained, using the amplitudes D-1(304), D-1(307), D-1(291.5) and D-1(296.5), respectively. Method showed good linearity in the ranges ( mug ml(-1)): 1.61-17.2 for OM; 2.15-21.50 for OMS; 2.13-21.30 for PANa and 2.0-20.0 for NPA, accuracy and precision (repeatability and reproducibility). The experimentally determined values of LOD (mug ml(-1)) were 1.126; 0.76; 0.691 and 0.716 for OM, OMS, PANa and NPA, respectively. The obtained values of 2.91% w/w for OMS and 3.58% w/w for NPA in the presence of their parent drug, by applying the method of standard additions, point out the usage of the proposed method in stability studies. Zero-crossing method in the f...irst-order derivative spectrophotometry showed the impurity-drug intermolecular interactions, due to the possible intermolecular hydrogen bonds, confirmed by divergences of experimentally obtained amplitudes for impurities OMS and NPA in comparison to expected values according to regression equations of calibration groups.
Кључне речи:
first-order derivative UV spectrophotometry / zero-crossing method / omeprazole / pantoprazole sodium / impurities / intermolecular interactionsИзвор:
Journal of Pharmaceutical and Biomedical Analysis, 2003, 32, 4-5, 1019-1027Издавач:
- Pergamon-Elsevier Science Ltd, Oxford
DOI: 10.1016/S0731-7085(03)00204-8
ISSN: 0731-7085
PubMed: 12899989
WoS: 000184881600044
Scopus: 2-s2.0-0042625010
Институција/група
PharmacyTY - JOUR AU - Karljiković-Rajić, Katarina AU - Novović, D AU - Marinković, Valentina AU - Agbaba, Danica PY - 2003 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/430 AB - The first-order UV-derivative spectrophotometry, applying zero-crossing method was developed for the determination of omeprazole (OM), omeprazole sulphone (OMS), pantoprazole sodium salt (PANa), and N-methylpantoprazole (NPA) in methanol-ammonia 4.0% v/v, where the sufficient spectra resolutions of drug and corresponding impurity were obtained, using the amplitudes D-1(304), D-1(307), D-1(291.5) and D-1(296.5), respectively. Method showed good linearity in the ranges ( mug ml(-1)): 1.61-17.2 for OM; 2.15-21.50 for OMS; 2.13-21.30 for PANa and 2.0-20.0 for NPA, accuracy and precision (repeatability and reproducibility). The experimentally determined values of LOD (mug ml(-1)) were 1.126; 0.76; 0.691 and 0.716 for OM, OMS, PANa and NPA, respectively. The obtained values of 2.91% w/w for OMS and 3.58% w/w for NPA in the presence of their parent drug, by applying the method of standard additions, point out the usage of the proposed method in stability studies. Zero-crossing method in the first-order derivative spectrophotometry showed the impurity-drug intermolecular interactions, due to the possible intermolecular hydrogen bonds, confirmed by divergences of experimentally obtained amplitudes for impurities OMS and NPA in comparison to expected values according to regression equations of calibration groups. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Journal of Pharmaceutical and Biomedical Analysis T1 - First-order UV-derivative spectrophotometry in the analysis of omeprazole and pantoprazole sodium salt and corresponding impurities VL - 32 IS - 4-5 SP - 1019 EP - 1027 DO - 10.1016/S0731-7085(03)00204-8 ER -
@article{ author = "Karljiković-Rajić, Katarina and Novović, D and Marinković, Valentina and Agbaba, Danica", year = "2003", abstract = "The first-order UV-derivative spectrophotometry, applying zero-crossing method was developed for the determination of omeprazole (OM), omeprazole sulphone (OMS), pantoprazole sodium salt (PANa), and N-methylpantoprazole (NPA) in methanol-ammonia 4.0% v/v, where the sufficient spectra resolutions of drug and corresponding impurity were obtained, using the amplitudes D-1(304), D-1(307), D-1(291.5) and D-1(296.5), respectively. Method showed good linearity in the ranges ( mug ml(-1)): 1.61-17.2 for OM; 2.15-21.50 for OMS; 2.13-21.30 for PANa and 2.0-20.0 for NPA, accuracy and precision (repeatability and reproducibility). The experimentally determined values of LOD (mug ml(-1)) were 1.126; 0.76; 0.691 and 0.716 for OM, OMS, PANa and NPA, respectively. The obtained values of 2.91% w/w for OMS and 3.58% w/w for NPA in the presence of their parent drug, by applying the method of standard additions, point out the usage of the proposed method in stability studies. Zero-crossing method in the first-order derivative spectrophotometry showed the impurity-drug intermolecular interactions, due to the possible intermolecular hydrogen bonds, confirmed by divergences of experimentally obtained amplitudes for impurities OMS and NPA in comparison to expected values according to regression equations of calibration groups.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Journal of Pharmaceutical and Biomedical Analysis", title = "First-order UV-derivative spectrophotometry in the analysis of omeprazole and pantoprazole sodium salt and corresponding impurities", volume = "32", number = "4-5", pages = "1019-1027", doi = "10.1016/S0731-7085(03)00204-8" }
Karljiković-Rajić, K., Novović, D., Marinković, V.,& Agbaba, D.. (2003). First-order UV-derivative spectrophotometry in the analysis of omeprazole and pantoprazole sodium salt and corresponding impurities. in Journal of Pharmaceutical and Biomedical Analysis Pergamon-Elsevier Science Ltd, Oxford., 32(4-5), 1019-1027. https://doi.org/10.1016/S0731-7085(03)00204-8
Karljiković-Rajić K, Novović D, Marinković V, Agbaba D. First-order UV-derivative spectrophotometry in the analysis of omeprazole and pantoprazole sodium salt and corresponding impurities. in Journal of Pharmaceutical and Biomedical Analysis. 2003;32(4-5):1019-1027. doi:10.1016/S0731-7085(03)00204-8 .
Karljiković-Rajić, Katarina, Novović, D, Marinković, Valentina, Agbaba, Danica, "First-order UV-derivative spectrophotometry in the analysis of omeprazole and pantoprazole sodium salt and corresponding impurities" in Journal of Pharmaceutical and Biomedical Analysis, 32, no. 4-5 (2003):1019-1027, https://doi.org/10.1016/S0731-7085(03)00204-8 . .