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First-order UV-derivative spectrophotometry in the analysis of omeprazole and pantoprazole sodium salt and corresponding impurities

Authorized Users Only
2003
Authors
Karljiković-Rajić, Katarina
Novović, D
Marinković, Valentina
Agbaba, Danica
Article (Published version)
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Abstract
The first-order UV-derivative spectrophotometry, applying zero-crossing method was developed for the determination of omeprazole (OM), omeprazole sulphone (OMS), pantoprazole sodium salt (PANa), and N-methylpantoprazole (NPA) in methanol-ammonia 4.0% v/v, where the sufficient spectra resolutions of drug and corresponding impurity were obtained, using the amplitudes D-1(304), D-1(307), D-1(291.5) and D-1(296.5), respectively. Method showed good linearity in the ranges ( mug ml(-1)): 1.61-17.2 for OM; 2.15-21.50 for OMS; 2.13-21.30 for PANa and 2.0-20.0 for NPA, accuracy and precision (repeatability and reproducibility). The experimentally determined values of LOD (mug ml(-1)) were 1.126; 0.76; 0.691 and 0.716 for OM, OMS, PANa and NPA, respectively. The obtained values of 2.91% w/w for OMS and 3.58% w/w for NPA in the presence of their parent drug, by applying the method of standard additions, point out the usage of the proposed method in stability studies. Zero-crossing method in the f...irst-order derivative spectrophotometry showed the impurity-drug intermolecular interactions, due to the possible intermolecular hydrogen bonds, confirmed by divergences of experimentally obtained amplitudes for impurities OMS and NPA in comparison to expected values according to regression equations of calibration groups.

Keywords:
first-order derivative UV spectrophotometry / zero-crossing method / omeprazole / pantoprazole sodium / impurities / intermolecular interactions
Source:
Journal of Pharmaceutical and Biomedical Analysis, 2003, 32, 4-5, 1019-1027
Publisher:
  • Pergamon-Elsevier Science Ltd, Oxford

DOI: 10.1016/S0731-7085(03)00204-8

ISSN: 0731-7085

PubMed: 12899989

WoS: 000184881600044

Scopus: 2-s2.0-0042625010
[ Google Scholar ]
89
75
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/430
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Karljiković-Rajić, Katarina
AU  - Novović, D
AU  - Marinković, Valentina
AU  - Agbaba, Danica
PY  - 2003
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/430
AB  - The first-order UV-derivative spectrophotometry, applying zero-crossing method was developed for the determination of omeprazole (OM), omeprazole sulphone (OMS), pantoprazole sodium salt (PANa), and N-methylpantoprazole (NPA) in methanol-ammonia 4.0% v/v, where the sufficient spectra resolutions of drug and corresponding impurity were obtained, using the amplitudes D-1(304), D-1(307), D-1(291.5) and D-1(296.5), respectively. Method showed good linearity in the ranges ( mug ml(-1)): 1.61-17.2 for OM; 2.15-21.50 for OMS; 2.13-21.30 for PANa and 2.0-20.0 for NPA, accuracy and precision (repeatability and reproducibility). The experimentally determined values of LOD (mug ml(-1)) were 1.126; 0.76; 0.691 and 0.716 for OM, OMS, PANa and NPA, respectively. The obtained values of 2.91% w/w for OMS and 3.58% w/w for NPA in the presence of their parent drug, by applying the method of standard additions, point out the usage of the proposed method in stability studies. Zero-crossing method in the first-order derivative spectrophotometry showed the impurity-drug intermolecular interactions, due to the possible intermolecular hydrogen bonds, confirmed by divergences of experimentally obtained amplitudes for impurities OMS and NPA in comparison to expected values according to regression equations of calibration groups.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - First-order UV-derivative spectrophotometry in the analysis of omeprazole and pantoprazole sodium salt and corresponding impurities
VL  - 32
IS  - 4-5
SP  - 1019
EP  - 1027
DO  - 10.1016/S0731-7085(03)00204-8
ER  - 
@article{
author = "Karljiković-Rajić, Katarina and Novović, D and Marinković, Valentina and Agbaba, Danica",
year = "2003",
abstract = "The first-order UV-derivative spectrophotometry, applying zero-crossing method was developed for the determination of omeprazole (OM), omeprazole sulphone (OMS), pantoprazole sodium salt (PANa), and N-methylpantoprazole (NPA) in methanol-ammonia 4.0% v/v, where the sufficient spectra resolutions of drug and corresponding impurity were obtained, using the amplitudes D-1(304), D-1(307), D-1(291.5) and D-1(296.5), respectively. Method showed good linearity in the ranges ( mug ml(-1)): 1.61-17.2 for OM; 2.15-21.50 for OMS; 2.13-21.30 for PANa and 2.0-20.0 for NPA, accuracy and precision (repeatability and reproducibility). The experimentally determined values of LOD (mug ml(-1)) were 1.126; 0.76; 0.691 and 0.716 for OM, OMS, PANa and NPA, respectively. The obtained values of 2.91% w/w for OMS and 3.58% w/w for NPA in the presence of their parent drug, by applying the method of standard additions, point out the usage of the proposed method in stability studies. Zero-crossing method in the first-order derivative spectrophotometry showed the impurity-drug intermolecular interactions, due to the possible intermolecular hydrogen bonds, confirmed by divergences of experimentally obtained amplitudes for impurities OMS and NPA in comparison to expected values according to regression equations of calibration groups.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "First-order UV-derivative spectrophotometry in the analysis of omeprazole and pantoprazole sodium salt and corresponding impurities",
volume = "32",
number = "4-5",
pages = "1019-1027",
doi = "10.1016/S0731-7085(03)00204-8"
}
Karljiković-Rajić, K., Novović, D., Marinković, V.,& Agbaba, D.. (2003). First-order UV-derivative spectrophotometry in the analysis of omeprazole and pantoprazole sodium salt and corresponding impurities. in Journal of Pharmaceutical and Biomedical Analysis
Pergamon-Elsevier Science Ltd, Oxford., 32(4-5), 1019-1027.
https://doi.org/10.1016/S0731-7085(03)00204-8
Karljiković-Rajić K, Novović D, Marinković V, Agbaba D. First-order UV-derivative spectrophotometry in the analysis of omeprazole and pantoprazole sodium salt and corresponding impurities. in Journal of Pharmaceutical and Biomedical Analysis. 2003;32(4-5):1019-1027.
doi:10.1016/S0731-7085(03)00204-8 .
Karljiković-Rajić, Katarina, Novović, D, Marinković, Valentina, Agbaba, Danica, "First-order UV-derivative spectrophotometry in the analysis of omeprazole and pantoprazole sodium salt and corresponding impurities" in Journal of Pharmaceutical and Biomedical Analysis, 32, no. 4-5 (2003):1019-1027,
https://doi.org/10.1016/S0731-7085(03)00204-8 . .

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