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dc.creatorJovanović Macura, Irena
dc.creatorĐuričić, Ivana
dc.creatorMajor, Tamara
dc.creatorMilanović, Desanka
dc.creatorBrkić, Marjana
dc.creatorŠobajić, Slađana
dc.creatorKanazir, Selma
dc.creatorIvković, Sanja
dc.date.accessioned2022-11-08T16:29:31Z
dc.date.available2022-11-08T16:29:31Z
dc.date.issued2022
dc.identifier.issn1756-4646
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/4309
dc.description.abstractThe recommended fish oil (FO) supplementation doses often yield low omega-3 polyunsaturated fatty acids (PUFAs) tissue bioavailability, and higher doses (up to 10 g per day) have been increasingly recommended. However, the exact effects of such FO supplementation on the healthy retina and retinal pigmented epithelium (RPE) are unknown. Our study showed that the high dose FO treatment did not imbalance the rigorous docosahexaenoic acid (DHA, C22:6n3) homeostasis in the retina and RPE in the three-month-old female B6/SLJ mice. Instead, we have found the significant increase in the expression of Mfsd2a, the main DHA transporter. Mfsd2a is also an essential regulator of blood vessel transcytosis and the decrease in Mfsd2a expression can be a risk factor for developing leaky blood vessels. Therefore, the high-dose FO supplementation emerges as the prophylactic fortifier of the retinal blood vessels.
dc.publisherElsevier Ltd
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200017/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200007/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceJournal of Functional Foods
dc.subjectDHA
dc.subjectEPA
dc.subjectFish oil
dc.subjectMfsd2a
dc.subjectRetina
dc.subjectRPE
dc.titleThe high-dose fish oil supplementation increased Mfsd2a expression without altering DHA levels in the retina of healthy mice
dc.typearticle
dc.rights.licenseBY
dc.citation.volume99
dc.citation.rankM21
dc.identifier.doi10.1016/j.jff.2022.105302
dc.identifier.scopus2-s2.0-85140635058
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/10549/The_high-dose_fish_PUB_2022.pdf
dc.type.versionpublishedVersion


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