Show simple item record

dc.creatorKarljiković-Rajić, Katarina
dc.creatorNovović, D
dc.creatorMarinković, Valentina
dc.creatorAgbaba, Danica
dc.date.accessioned2019-09-02T10:56:54Z
dc.date.available2019-09-02T10:56:54Z
dc.date.issued2003
dc.identifier.issn0731-7085
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/430
dc.description.abstractThe first-order UV-derivative spectrophotometry, applying zero-crossing method was developed for the determination of omeprazole (OM), omeprazole sulphone (OMS), pantoprazole sodium salt (PANa), and N-methylpantoprazole (NPA) in methanol-ammonia 4.0% v/v, where the sufficient spectra resolutions of drug and corresponding impurity were obtained, using the amplitudes D-1(304), D-1(307), D-1(291.5) and D-1(296.5), respectively. Method showed good linearity in the ranges ( mug ml(-1)): 1.61-17.2 for OM; 2.15-21.50 for OMS; 2.13-21.30 for PANa and 2.0-20.0 for NPA, accuracy and precision (repeatability and reproducibility). The experimentally determined values of LOD (mug ml(-1)) were 1.126; 0.76; 0.691 and 0.716 for OM, OMS, PANa and NPA, respectively. The obtained values of 2.91% w/w for OMS and 3.58% w/w for NPA in the presence of their parent drug, by applying the method of standard additions, point out the usage of the proposed method in stability studies. Zero-crossing method in the first-order derivative spectrophotometry showed the impurity-drug intermolecular interactions, due to the possible intermolecular hydrogen bonds, confirmed by divergences of experimentally obtained amplitudes for impurities OMS and NPA in comparison to expected values according to regression equations of calibration groups.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.rightsrestrictedAccess
dc.sourceJournal of Pharmaceutical and Biomedical Analysis
dc.subjectfirst-order derivative UV spectrophotometryen
dc.subjectzero-crossing methoden
dc.subjectomeprazoleen
dc.subjectpantoprazole sodiumen
dc.subjectimpuritiesen
dc.subjectintermolecular interactionsen
dc.titleFirst-order UV-derivative spectrophotometry in the analysis of omeprazole and pantoprazole sodium salt and corresponding impuritiesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМаринковић, Валентина; Карљиковић-Рајић, Катарина; Aгбаба, Даница; Нововић, Д;
dc.citation.volume32
dc.citation.issue4-5
dc.citation.spage1019
dc.citation.epage1027
dc.citation.other32(4-5): 1019-1027
dc.citation.rankM22
dc.identifier.wos000184881600044
dc.identifier.doi10.1016/S0731-7085(03)00204-8
dc.identifier.pmid12899989
dc.identifier.scopus2-s2.0-0042625010
dc.identifier.rcubconv_1418
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record