Behavioural and molecular study of the effects of rosuvastatin on acquisition and retention of spatial memory impaired by H-89 in rats
Аутори
Tabrizian, KavehMiri, Fatemeh
Haseli, Shiva
Shahraki, Jafar
Belaran, Maryam
Rezaee, Ramin
Buha, Aleksandra
Tsatsakis, Aristidis
Arsene, Andreea Letiția
Șerban, Dragoș
Velescu, Bruno Ștefan
Hashemzaei, Mahmoud
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
There is controversy on the effect of statins on cognitive functions such as spatial memory. In the present study, effect of ten- day oral gavage of rosuvastatin (Ros, 20 mg/kg) on spatial learning and spatial memory retention impaired by H-89, was investigated in male rats. This study was comprised of two sets of experiments each including the following 3 groups (n = 8): Control group treated with DMSO; H-89 group received bilateral intra-hippocampal H-89 (10 μM/side, in DMSO) and Ros- H-89 group orally treated with Ros (20 mg/kg) and H-89 (similar to the H-89 group). For spatial learning (acquisition phase) assessment, from day 7 of Ros gavage, rats were trained in the Morris water maze (MWM) for four days (one block of 4 stages each day) and received daily H-89, 30 min after Ros gavage. On day 11, the probe test was performed. Also, to assess spatial memory retention, from day 7 to 10 of Ros gavage, rats were trained in MWM but received H-89 on day 10 only. On day 12, the probe test... was performed. Besides, CREB and p-CREB protein expression was assessed in hippocampal samples and oxidative stress status was assessed in serum samples. We observed that H-89 led to a clear impairment of the spatial learning and spatial memory recall, increased levels of lipid peroxidation and downregulated CREB and p-CREB proteins, compared to the control group. However, Ros prevented H-89-induced deleterious consequences which might be probably in part due to its ameliorative effects on lipid peroxidation index and CREB and p-CREB expression.
Кључне речи:
Morris water maze / protein kinase AII inhibitor / protein markers / rosuvastatin / spatial memoryИзвор:
Farmacia, 2022, 70, 5, 904-911Издавач:
- Societatea de Științe Farmaceutice din România
DOI: 10.31925/farmacia.2022.5.16
ISSN: 0014-8237
WoS: 000880417600016
Scopus: 2-s2.0-85140826036
Институција/група
PharmacyTY - JOUR AU - Tabrizian, Kaveh AU - Miri, Fatemeh AU - Haseli, Shiva AU - Shahraki, Jafar AU - Belaran, Maryam AU - Rezaee, Ramin AU - Buha, Aleksandra AU - Tsatsakis, Aristidis AU - Arsene, Andreea Letiția AU - Șerban, Dragoș AU - Velescu, Bruno Ștefan AU - Hashemzaei, Mahmoud PY - 2022 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4315 AB - There is controversy on the effect of statins on cognitive functions such as spatial memory. In the present study, effect of ten- day oral gavage of rosuvastatin (Ros, 20 mg/kg) on spatial learning and spatial memory retention impaired by H-89, was investigated in male rats. This study was comprised of two sets of experiments each including the following 3 groups (n = 8): Control group treated with DMSO; H-89 group received bilateral intra-hippocampal H-89 (10 μM/side, in DMSO) and Ros- H-89 group orally treated with Ros (20 mg/kg) and H-89 (similar to the H-89 group). For spatial learning (acquisition phase) assessment, from day 7 of Ros gavage, rats were trained in the Morris water maze (MWM) for four days (one block of 4 stages each day) and received daily H-89, 30 min after Ros gavage. On day 11, the probe test was performed. Also, to assess spatial memory retention, from day 7 to 10 of Ros gavage, rats were trained in MWM but received H-89 on day 10 only. On day 12, the probe test was performed. Besides, CREB and p-CREB protein expression was assessed in hippocampal samples and oxidative stress status was assessed in serum samples. We observed that H-89 led to a clear impairment of the spatial learning and spatial memory recall, increased levels of lipid peroxidation and downregulated CREB and p-CREB proteins, compared to the control group. However, Ros prevented H-89-induced deleterious consequences which might be probably in part due to its ameliorative effects on lipid peroxidation index and CREB and p-CREB expression. PB - Societatea de Științe Farmaceutice din România T2 - Farmacia T1 - Behavioural and molecular study of the effects of rosuvastatin on acquisition and retention of spatial memory impaired by H-89 in rats VL - 70 IS - 5 SP - 904 EP - 911 DO - 10.31925/farmacia.2022.5.16 ER -
@article{ author = "Tabrizian, Kaveh and Miri, Fatemeh and Haseli, Shiva and Shahraki, Jafar and Belaran, Maryam and Rezaee, Ramin and Buha, Aleksandra and Tsatsakis, Aristidis and Arsene, Andreea Letiția and Șerban, Dragoș and Velescu, Bruno Ștefan and Hashemzaei, Mahmoud", year = "2022", abstract = "There is controversy on the effect of statins on cognitive functions such as spatial memory. In the present study, effect of ten- day oral gavage of rosuvastatin (Ros, 20 mg/kg) on spatial learning and spatial memory retention impaired by H-89, was investigated in male rats. This study was comprised of two sets of experiments each including the following 3 groups (n = 8): Control group treated with DMSO; H-89 group received bilateral intra-hippocampal H-89 (10 μM/side, in DMSO) and Ros- H-89 group orally treated with Ros (20 mg/kg) and H-89 (similar to the H-89 group). For spatial learning (acquisition phase) assessment, from day 7 of Ros gavage, rats were trained in the Morris water maze (MWM) for four days (one block of 4 stages each day) and received daily H-89, 30 min after Ros gavage. On day 11, the probe test was performed. Also, to assess spatial memory retention, from day 7 to 10 of Ros gavage, rats were trained in MWM but received H-89 on day 10 only. On day 12, the probe test was performed. Besides, CREB and p-CREB protein expression was assessed in hippocampal samples and oxidative stress status was assessed in serum samples. We observed that H-89 led to a clear impairment of the spatial learning and spatial memory recall, increased levels of lipid peroxidation and downregulated CREB and p-CREB proteins, compared to the control group. However, Ros prevented H-89-induced deleterious consequences which might be probably in part due to its ameliorative effects on lipid peroxidation index and CREB and p-CREB expression.", publisher = "Societatea de Științe Farmaceutice din România", journal = "Farmacia", title = "Behavioural and molecular study of the effects of rosuvastatin on acquisition and retention of spatial memory impaired by H-89 in rats", volume = "70", number = "5", pages = "904-911", doi = "10.31925/farmacia.2022.5.16" }
Tabrizian, K., Miri, F., Haseli, S., Shahraki, J., Belaran, M., Rezaee, R., Buha, A., Tsatsakis, A., Arsene, A. L., Șerban, D., Velescu, B. Ș.,& Hashemzaei, M.. (2022). Behavioural and molecular study of the effects of rosuvastatin on acquisition and retention of spatial memory impaired by H-89 in rats. in Farmacia Societatea de Științe Farmaceutice din România., 70(5), 904-911. https://doi.org/10.31925/farmacia.2022.5.16
Tabrizian K, Miri F, Haseli S, Shahraki J, Belaran M, Rezaee R, Buha A, Tsatsakis A, Arsene AL, Șerban D, Velescu BȘ, Hashemzaei M. Behavioural and molecular study of the effects of rosuvastatin on acquisition and retention of spatial memory impaired by H-89 in rats. in Farmacia. 2022;70(5):904-911. doi:10.31925/farmacia.2022.5.16 .
Tabrizian, Kaveh, Miri, Fatemeh, Haseli, Shiva, Shahraki, Jafar, Belaran, Maryam, Rezaee, Ramin, Buha, Aleksandra, Tsatsakis, Aristidis, Arsene, Andreea Letiția, Șerban, Dragoș, Velescu, Bruno Ștefan, Hashemzaei, Mahmoud, "Behavioural and molecular study of the effects of rosuvastatin on acquisition and retention of spatial memory impaired by H-89 in rats" in Farmacia, 70, no. 5 (2022):904-911, https://doi.org/10.31925/farmacia.2022.5.16 . .