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COVID-19 signalome: Pathways for SARS-CoV-2 infection and impact on COVID-19 associated comorbidity
dc.creator | Lundstrom, Kenneth | |
dc.creator | Hromić-Jahjefendić, Altijana | |
dc.creator | Bilajac, Esma | |
dc.creator | Aljabali, Alla | |
dc.creator | Baralić, Katarina | |
dc.creator | Sabri, Nagwa | |
dc.creator | Shehata, Eslam | |
dc.creator | Raslan, Mohamed | |
dc.creator | Ferreira, Ana Cláudia | |
dc.creator | Orlandi, Lidiane | |
dc.creator | Serrano-Aroca, Ángel | |
dc.creator | Tambuwala, Murtaza | |
dc.creator | Uversky, Vladimir | |
dc.creator | Azevedo, Vasco | |
dc.creator | Alzahrani, Khalid | |
dc.creator | Alsharif, Khalaf | |
dc.creator | Halawani, Ibrahim | |
dc.creator | Alzahrani, Fuad | |
dc.creator | Redwan, Elrashdy | |
dc.creator | Barh, Debmalya | |
dc.date.accessioned | 2022-11-22T14:59:48Z | |
dc.date.available | 2022-11-22T14:59:48Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 0898-6568 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/4317 | |
dc.description.abstract | The COVID-19 pandemic has been the focus of research the past two years. The major breakthrough was made by discovering pathways related to SARS-CoV-2 infection through cellular interaction by angiotensin-converting enzyme (ACE2) and cytokine storm. The presence of ACE2 in lungs, intestines, cardiovascular tissues, brain, kidneys, liver, and eyes shows that SARS-CoV-2 may have targeted these organs to further activate intracellular signalling pathways that lead to cytokine release syndrome. It has also been reported that SARS-CoV-2 can hijack coatomer protein-I (COPI) for S protein retrograde trafficking to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC), which, in turn, acts as the assembly site for viral progeny. In infected cells, the newly synthesized S protein in endoplasmic reticulum (ER) is transported first to the Golgi body, and then from the Golgi body to the ERGIC compartment resulting in the formation of specific a motif at the C-terminal end. This review summarizes major events of SARS-CoV-2 infection route, immune response following host-cell infection as an important factor for disease outcome, as well as comorbidity issues of various tissues and organs arising due to COVID-19. Investigations on alterations of host-cell machinery and viral interactions with multiple intracellular signaling pathways could represent a major factor in more effective disease management. | |
dc.publisher | Elsevier Inc. | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Cellular Signalling | |
dc.subject | SARS-CoV-2 | |
dc.subject | ACE2 | |
dc.subject | Pathway interactions | |
dc.subject | Signaling pathways | |
dc.subject | Signalomes | |
dc.title | COVID-19 signalome: Pathways for SARS-CoV-2 infection and impact on COVID-19 associated comorbidity | |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dc.citation.volume | 101 | |
dc.citation.rank | M22~ | |
dc.identifier.wos | 000891857700004 | |
dc.identifier.doi | 10.1016/j.cellsig.2022.110495 | |
dc.identifier.pmid | 36252792 | |
dc.identifier.scopus | 2-s2.0-85141534117 | |
dc.identifier.fulltext | http://farfar.pharmacy.bg.ac.rs/bitstream/id/10840/COVID-19_signalome_Pathways_pub_2023.pdf | |
dc.type.version | publishedVersion |