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Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic Activity

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2022
Black_Trumpet_Craterellus_pub_2022.pdf (465.8Kb)
Authors
Radović, Jelena
Leković, Aleksandra
Tačić, Ana
Dodevska, Margarita
Stanojković, Tatjana
Marinković, Tijana
Jelić, Čedomir
Kundaković-Vasović, Tatjana
Article (Published version)
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Abstract
Nutritional value and chemical composition, including the content of vitamins, fatty acids, 5'-nucleotides and nucleosides and amino acids, as well as biological activities, including antioxidant, angiotensin converting enzyme (ACE) inhibitory and cytotoxic activity of black trumpet (Craterellus cornucopioides (L.) Pers.) were tested in vitro. C. cornucopioides was low in energy, fat and carbohydrate contents, but rich in dietary fibre, especially β-glucan as well as niacin and α-tocopherol. The content of essential and non-essential free amino acids was 1.49 and 5.48 mg/g dry weight (dw). The nucleosides and 5'-nucleotides were determined at 1.84 and 3.99 mg/g dw, respectively. The share of unsaturated fatty acids (UFAs) was 75.92% with oleic acid as the major UFA. Cyclohexane and dichloromethane extracts expressed significant cytotoxic activity against selected cell lines, human epithelial cervical cancer cells (HeLa), adenocarcinomic human alveolar basal epithelial cells (A549), col...orectal cancer cells (LS174) and normal MRC-5 human embryonic lung fibroblast cells (IC50 of 78.3-155.6 μg/mL). ACE inhibitory activity of the aqueous extract was strong with an IC50 of 0.74 μg/mL. It can be concluded that black trumpet is a good source of nutrients, such as vitamins, dietary fibres, amino acids, nucleotides and fatty acids, which contribute to the overall nutritional value of this fungus with potential for ACE inhibitory activity and use in anti-hypertensive diet.

Keywords:
cytotoxicity / nutrients / angiotensin converting enzyme inhibition / Craterellus cornucopioides / β-glucan
Source:
Polish Journal of Food and Nutrition Sciences, 2022, 72, 2, 171-181
Publisher:
  • Polish Academy Sciences. Institute of Animal Reproduction and Food Research
Funding / projects:
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200161 (University of Belgrade, Faculty of Pharmacy) (RS-200161)

DOI: 10.31883/pjfns/149914

ISSN: 1230-0322

WoS: 000816960500006

Scopus: 2-s2.0-85141942756
[ Google Scholar ]
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/4324
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Radović, Jelena
AU  - Leković, Aleksandra
AU  - Tačić, Ana
AU  - Dodevska, Margarita
AU  - Stanojković, Tatjana
AU  - Marinković, Tijana
AU  - Jelić, Čedomir
AU  - Kundaković-Vasović, Tatjana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4324
AB  - Nutritional value and chemical composition, including the content of vitamins, fatty acids, 5'-nucleotides and nucleosides and amino acids, as well as biological activities, including antioxidant, angiotensin converting enzyme (ACE) inhibitory and cytotoxic activity of black trumpet (Craterellus cornucopioides (L.) Pers.) were tested in vitro. C. cornucopioides was low in energy, fat and carbohydrate contents, but rich in dietary fibre, especially β-glucan as well as niacin and α-tocopherol. The content of essential and non-essential free amino acids was 1.49 and 5.48 mg/g dry weight (dw). The nucleosides and 5'-nucleotides were determined at 1.84 and 3.99 mg/g dw, respectively. The share of unsaturated fatty acids (UFAs) was 75.92% with oleic acid as the major UFA. Cyclohexane and dichloromethane extracts expressed significant cytotoxic activity against selected cell lines, human epithelial cervical cancer cells (HeLa), adenocarcinomic human alveolar basal epithelial cells (A549), colorectal cancer cells (LS174) and normal MRC-5 human embryonic lung fibroblast cells (IC50 of 78.3-155.6 μg/mL). ACE inhibitory activity of the aqueous extract was strong with an IC50 of 0.74 μg/mL. It can be concluded that black trumpet is a good source of nutrients, such as vitamins, dietary fibres, amino acids, nucleotides and fatty acids, which contribute to the overall nutritional value of this fungus with potential for ACE inhibitory activity and use in anti-hypertensive diet.
PB  - Polish Academy Sciences. Institute of Animal Reproduction and Food Research
T2  - Polish Journal of Food and Nutrition Sciences
T1  - Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic Activity
VL  - 72
IS  - 2
SP  - 171
EP  - 181
DO  - 10.31883/pjfns/149914
ER  - 
@article{
author = "Radović, Jelena and Leković, Aleksandra and Tačić, Ana and Dodevska, Margarita and Stanojković, Tatjana and Marinković, Tijana and Jelić, Čedomir and Kundaković-Vasović, Tatjana",
year = "2022",
abstract = "Nutritional value and chemical composition, including the content of vitamins, fatty acids, 5'-nucleotides and nucleosides and amino acids, as well as biological activities, including antioxidant, angiotensin converting enzyme (ACE) inhibitory and cytotoxic activity of black trumpet (Craterellus cornucopioides (L.) Pers.) were tested in vitro. C. cornucopioides was low in energy, fat and carbohydrate contents, but rich in dietary fibre, especially β-glucan as well as niacin and α-tocopherol. The content of essential and non-essential free amino acids was 1.49 and 5.48 mg/g dry weight (dw). The nucleosides and 5'-nucleotides were determined at 1.84 and 3.99 mg/g dw, respectively. The share of unsaturated fatty acids (UFAs) was 75.92% with oleic acid as the major UFA. Cyclohexane and dichloromethane extracts expressed significant cytotoxic activity against selected cell lines, human epithelial cervical cancer cells (HeLa), adenocarcinomic human alveolar basal epithelial cells (A549), colorectal cancer cells (LS174) and normal MRC-5 human embryonic lung fibroblast cells (IC50 of 78.3-155.6 μg/mL). ACE inhibitory activity of the aqueous extract was strong with an IC50 of 0.74 μg/mL. It can be concluded that black trumpet is a good source of nutrients, such as vitamins, dietary fibres, amino acids, nucleotides and fatty acids, which contribute to the overall nutritional value of this fungus with potential for ACE inhibitory activity and use in anti-hypertensive diet.",
publisher = "Polish Academy Sciences. Institute of Animal Reproduction and Food Research",
journal = "Polish Journal of Food and Nutrition Sciences",
title = "Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic Activity",
volume = "72",
number = "2",
pages = "171-181",
doi = "10.31883/pjfns/149914"
}
Radović, J., Leković, A., Tačić, A., Dodevska, M., Stanojković, T., Marinković, T., Jelić, Č.,& Kundaković-Vasović, T.. (2022). Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic Activity. in Polish Journal of Food and Nutrition Sciences
Polish Academy Sciences. Institute of Animal Reproduction and Food Research., 72(2), 171-181.
https://doi.org/10.31883/pjfns/149914
Radović J, Leković A, Tačić A, Dodevska M, Stanojković T, Marinković T, Jelić Č, Kundaković-Vasović T. Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic Activity. in Polish Journal of Food and Nutrition Sciences. 2022;72(2):171-181.
doi:10.31883/pjfns/149914 .
Radović, Jelena, Leković, Aleksandra, Tačić, Ana, Dodevska, Margarita, Stanojković, Tatjana, Marinković, Tijana, Jelić, Čedomir, Kundaković-Vasović, Tatjana, "Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic Activity" in Polish Journal of Food and Nutrition Sciences, 72, no. 2 (2022):171-181,
https://doi.org/10.31883/pjfns/149914 . .

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