Приказ основних података о документу
ex vivo–in vivo comparison of drug penetration analysis by confocal Raman microspectroscopy and tape stripping
dc.creator | Krombholz, Richard | |
dc.creator | Fressle, Stefanie | |
dc.creator | Nikolić, Ines | |
dc.creator | Pantelić, Ivana | |
dc.creator | Savić, Snežana | |
dc.creator | Crevar-Sakač, Milkica | |
dc.creator | Lunter, Dominique | |
dc.date.accessioned | 2022-12-07T16:42:36Z | |
dc.date.available | 2022-12-07T16:42:36Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 0906-6705 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/4333 | |
dc.description.abstract | When it comes to skin penetration analysis of a topically applied formulation, the number of suitable methods is limited, and they often lack in spatial resolution. In vivo studies are pivotal, especially in the approval of a new product, but high costs and ethical difficulties are limiting factors. For that reason, good ex vivo models for testing skin penetration are crucial. In this study, caffeine was used as a hydrophilic model drug, applied as a 2% (w/w) hydrogel, to compare different techniques for skin penetration analysis. Confocal Raman microspectroscopy (CRM) and tape stripping with subsequent HPLC analysis were used to quantify caffeine. Experiments were performed ex vivo and in vivo. Furthermore, the effect of 5% (w/w) 1,2-pentanediol on caffeine skin penetration was tested, to compare those methods regarding their effectiveness in detecting differences between both formulations. | |
dc.publisher | John Wiley and Sons Inc | |
dc.relation | Ministry of Education, Science and Technological Development, Republic of Serbia (grant numbers 57514345 and 451–03‐01855/2019–09/12). | |
dc.relation | Industrial Collective Research, German Federation of Industrial Research Associations (Forschungsvereinigung der Arzneimittelhersteller) and German Federal Ministry for economic affairs and energy | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Experimental Dermatology | |
dc.subject | caffeine | |
dc.subject | confocal Raman spectroscopy | |
dc.subject | dermatology | |
dc.subject | drug delivery | |
dc.subject | skin barrier | |
dc.subject | skin penetration | |
dc.title | ex vivo–in vivo comparison of drug penetration analysis by confocal Raman microspectroscopy and tape stripping | |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dc.citation.volume | 31 | |
dc.citation.issue | 12 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000852120500001 | |
dc.identifier.doi | 10.1111/exd.14672 | |
dc.identifier.scopus | 2-s2.0-85137507915 | |
dc.identifier.fulltext | http://farfar.pharmacy.bg.ac.rs/bitstream/id/11142/ex_vivo_in_pub_2022.pdf | |
dc.type.version | publishedVersion |