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Orodispersible films — Pharmaceutical development for improved performance: A review

Authorized Users Only
2022
Authors
Turković, Erna
Vasiljević, Ivana
Drašković, Milica
Parojčić, Jelena
Article (Published version)
Metadata
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Abstract
Orodispersible films (ODFs) have recently emerged as innovative dosage form which provides distinct advantages in the patient centric pharmaceutical drug product design due to inherent dosing flexibility and improved patient acceptability. Although their potential advantages in pharmacotherapy are well recognized, there is still a lot of research work to be done in order to explore and understand complex relationships among different formulation factors, film mechanical properties, and their bioperformance. Lack of standardized characterization methods and relevant specifications pose additional limitation for their wider application. In the present study, in-depth review of the available body of data published on ODF development and characterization was performed. In total, 112 papers published between November 2008 and April 2022 were taken into consideration for dataset building. Data collected have been critically evaluated and compiled into the representative dataset formed around... three domains, namely: (A) Manufacturing method and composition; (B) ODF characteristics; and (C) ODF sensory attributes. Based on the investigated dataset, an attempt was made to identify the acceptable range of Critical Quality Attributes (CQA) values and propose ODF specific Quality Targeted Product Profile (QTPP) as a foundation which should guide and facilitate pharmaceutical development.

Keywords:
Disintegration time / Critical quality attributes / Mechanical properties / ODF composition / ODF manufacturing methods / ODF sensory attributes / Quality target product profile
Source:
Journal of Drug Delivery Science and Technology, 2022, 75
Publisher:
  • Elsevier B.V.
Funding / projects:
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200161 (University of Belgrade, Faculty of Pharmacy) (RS-200161)

DOI: 10.1016/j.jddst.2022.103708

ISSN: 1773-2247

WoS: 000859535100003

Scopus: 2-s2.0-85136287303
[ Google Scholar ]
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/4336
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Turković, Erna
AU  - Vasiljević, Ivana
AU  - Drašković, Milica
AU  - Parojčić, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4336
AB  - Orodispersible films (ODFs) have recently emerged as innovative dosage form which provides distinct advantages in the patient centric pharmaceutical drug product design due to inherent dosing flexibility and improved patient acceptability. Although their potential advantages in pharmacotherapy are well recognized, there is still a lot of research work to be done in order to explore and understand complex relationships among different formulation factors, film mechanical properties, and their bioperformance. Lack of standardized characterization methods and relevant specifications pose additional limitation for their wider application. In the present study, in-depth review of the available body of data published on ODF development and characterization was performed. In total, 112 papers published between November 2008 and April 2022 were taken into consideration for dataset building. Data collected have been critically evaluated and compiled into the representative dataset formed around three domains, namely: (A) Manufacturing method and composition; (B) ODF characteristics; and (C) ODF sensory attributes. Based on the investigated dataset, an attempt was made to identify the acceptable range of Critical Quality Attributes (CQA) values and propose ODF specific Quality Targeted Product Profile (QTPP) as a foundation which should guide and facilitate pharmaceutical development.
PB  - Elsevier B.V.
T2  - Journal of Drug Delivery Science and Technology
T1  - Orodispersible films — Pharmaceutical development for improved performance: A review
VL  - 75
DO  - 10.1016/j.jddst.2022.103708
ER  - 
@article{
author = "Turković, Erna and Vasiljević, Ivana and Drašković, Milica and Parojčić, Jelena",
year = "2022",
abstract = "Orodispersible films (ODFs) have recently emerged as innovative dosage form which provides distinct advantages in the patient centric pharmaceutical drug product design due to inherent dosing flexibility and improved patient acceptability. Although their potential advantages in pharmacotherapy are well recognized, there is still a lot of research work to be done in order to explore and understand complex relationships among different formulation factors, film mechanical properties, and their bioperformance. Lack of standardized characterization methods and relevant specifications pose additional limitation for their wider application. In the present study, in-depth review of the available body of data published on ODF development and characterization was performed. In total, 112 papers published between November 2008 and April 2022 were taken into consideration for dataset building. Data collected have been critically evaluated and compiled into the representative dataset formed around three domains, namely: (A) Manufacturing method and composition; (B) ODF characteristics; and (C) ODF sensory attributes. Based on the investigated dataset, an attempt was made to identify the acceptable range of Critical Quality Attributes (CQA) values and propose ODF specific Quality Targeted Product Profile (QTPP) as a foundation which should guide and facilitate pharmaceutical development.",
publisher = "Elsevier B.V.",
journal = "Journal of Drug Delivery Science and Technology",
title = "Orodispersible films — Pharmaceutical development for improved performance: A review",
volume = "75",
doi = "10.1016/j.jddst.2022.103708"
}
Turković, E., Vasiljević, I., Drašković, M.,& Parojčić, J.. (2022). Orodispersible films — Pharmaceutical development for improved performance: A review. in Journal of Drug Delivery Science and Technology
Elsevier B.V.., 75.
https://doi.org/10.1016/j.jddst.2022.103708
Turković E, Vasiljević I, Drašković M, Parojčić J. Orodispersible films — Pharmaceutical development for improved performance: A review. in Journal of Drug Delivery Science and Technology. 2022;75.
doi:10.1016/j.jddst.2022.103708 .
Turković, Erna, Vasiljević, Ivana, Drašković, Milica, Parojčić, Jelena, "Orodispersible films — Pharmaceutical development for improved performance: A review" in Journal of Drug Delivery Science and Technology, 75 (2022),
https://doi.org/10.1016/j.jddst.2022.103708 . .

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