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dc.creatorStevanović, Magdalena M.
dc.creatorFilipović, Nenad
dc.creatorKuzmanović, Maja
dc.creatorTomić, Nina
dc.creatorUšjak, Dušan
dc.creatorMilenković, Marina
dc.creatorZheng, Kai
dc.creatorStampfl, Juergen
dc.creatorBoccaccini, Aldo R.
dc.date.accessioned2022-12-26T14:46:38Z
dc.date.available2022-12-26T14:46:38Z
dc.date.issued2022
dc.identifier.issn0885-3282
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/4357
dc.description.abstractMultidrug-resistant bacterial strains represent an emerging global health threat and a great obstacle for bone tissue engineering. One of the major components of the extracellular matrix of the bone is a collagen protein, while selenium is an element that has antimicrobial potential, and is also important for bone metabolism and bone health. Here we represent the incorporation of selenium nanoparticles (SeNPs) synthesized by the green chemical reduction method into collagen gels to produce a composite material, collagen/SeNPs, with antimicrobial properties. The samples were comprehensively characterized by zeta potential measurements, dynamic light scattering inductively coupled plasma-mass spectrometry (ICP-MS), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), optical microscopy, field-emission scanning electron microscopy (FE-SEM), and differential scanning calorimetry The cytotoxicity of the SeNPS, as well as collagen/SeNPs, was tested on the MRC-5 cells. It was revealed that collagen/SeNPS expressed a lower cytotoxic effect. Collagen/SeNPs showed significant antibacterial activity against all tested Gram-positive strains, the major causative agents of orthopedic infections as well as Candida albicans. Furthermore, three-dimensional β-tricalcium phosphate (3D-TCP) scaffolds were fabricated by a well-established 3D printing (lithography) method, and afterward preliminary coated by newly-synthesized SeNPs or collagen/SeNPs. In addition, uncoated 3D-TCP scaffolds as well as coated by collagen/SeNPs were subjected to biofilm formation. The production of Staphylococcus aureus biofilm on coated scaffolds by collagen/SeNPs was significantly reduced compared to the uncoated ones.
dc.publisherSAGE Publications Ltd
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200175/RS//
dc.relationThe bilateral project between Serbia and Austria (project No: SRB 24/2018, project title: Scaffolds with controlled 3-D architecture designed by photopolymerization
dc.relationBilateral project between Serbia and Germany (DAAD project 57514776)
dc.rightsrestrictedAccess
dc.sourceJournal of Biomaterials Applications
dc.subjectbiomaterials
dc.subjectcomposite materials
dc.subjectselenium nanoparticles
dc.subjectcollagen
dc.subjectantimicrobial activity
dc.subjectscaffolds
dc.titleSynthesis and characterization of a collagen-based composite material containing selenium nanoparticles
dc.typearticle
dc.rights.licenseARR
dc.citation.volume36
dc.citation.issue10
dc.citation.spage1800
dc.citation.epage1811
dc.citation.rankM23
dc.identifier.wos000764244600001
dc.identifier.doi10.1177/08853282211073731
dc.identifier.scopus2-s2.0-85126034982
dc.type.versionpublishedVersion


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Приказ основних података о документу