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dc.creatorVujčić, Sanja
dc.creatorKotur-Stevuljević, Jelena
dc.creatorVekić, Jelena
dc.creatorPerović-Blagojević, Iva
dc.creatorStefanović, Tatjana
dc.creatorIlić-Mijailović, Sanja
dc.creatorKoprivica Uzelac, Branka
dc.creatorBosić, Srećko
dc.creatorAntonić, Tamara
dc.creatorGuzonjić, Azra
dc.creatorMastilović, Ana-Marija
dc.creatorMarković, Zorica
dc.creatorRizzo, Manfredi
dc.date.accessioned2023-01-09T12:08:12Z
dc.date.available2023-01-09T12:08:12Z
dc.date.issued2022
dc.identifier.issn1010-660X
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/4369
dc.description.abstractBackground and Objectives: Diabetic foot (DF) development is driven by complex interactions of hyperglycemia, inflammation, and oxidative stress (OS). We aimed to investigate OS and inflammatory biomarkers in patients with DF and their potential to improve early diagnosis and management of DF. Materials and Methods: The prooxidant–antioxidant balance (PAB), superoxide dismutase (SOD), total oxidative status (TOS), total sulfhydryl groups (SHG), routine biochemical parameters, and complete blood count were determined in 42 patients with type-2 DM, of which 23 patients had DF, while 19 patients were without DF complications. The neutrophils-to-lymphocyte ratio (NLR) was evaluated as a biomarker of inflammation. Results: Patients with DF had significantly higher (p < 0.05) PAB levels (170 ± 33.9 U/L) compared to those without DF complications (142 ± 31.3 U/L). In addition, patients with DF had significantly reduced SOD activities (p < 0.01). NLR values were significantly higher in the DF group (median: 2.8; interquartile range: 2.0–4.3) than in the group without DF (median: 1.4; interquartile range: 1.4–2.1; p < 0.01). A positive correlation was found between the PAB and NLR index (r = 0.449; p < 0.05). The diagnostic accuracy of both PAB (AUC = 0.741; p < 0.01) and NLR (AUC = 0.760; p < 0.01) was estimated as acceptable. Conclusions: In conclusion, the development of DF is associated with enhanced OS and inflammation processes. PAB and NLR could be useful non-invasive biomarkers of DF development.
dc.publisherMDPI
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceMedicina (Lithuania)
dc.subjectoxidative stress
dc.subjectdiabetes mellitus
dc.subjectdiabetic foot
dc.subjectNLR
dc.subjectPAB
dc.titleOxidative Stress and Inflammatory Biomarkers in Patients with Diabetic Foot
dc.typearticle
dc.rights.licenseBY
dc.citation.volume58
dc.citation.issue12
dc.citation.rankM22
dc.identifier.wos000902834300001
dc.identifier.doi10.3390/medicina58121866
dc.identifier.scopus2-s2.0-85144545308
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/11371/Oxidative_Stress_and_pub_2022.pdf
dc.type.versionpublishedVersion


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