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dc.creatorBaralić, Katarina
dc.creatorŽivančević, Katarina
dc.creatorBožić, Dragica
dc.creatorĐukić-Ćosić, Danijela
dc.date.accessioned2023-01-10T08:53:00Z
dc.date.available2023-01-10T08:53:00Z
dc.date.issued2023
dc.identifier.issn0278-6915
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/4371
dc.description.abstractEnvironmentally relevant toxic substances may affect human health, provoking numerous harmful effects on central nervous, respiratory, cardiovascular, endocrine and reproductive system, and even cause various types of carcinoma. These substances, to which general population is constantly and simultaneously exposed, enter human body via food and water, but also by inhalation and dermal contact, while accumulating evidence suggests that probiotic cultures are able to efficiently adsorb and/or degrade them. Cell wall of probiotic bacteria/fungi, which contains structures such as exopolysaccharide, teichoic acid, protein and peptidoglycan components, is considered the main place of toxic substances adsorption. Moreover, probiotics are able to induce metabolism and degradation of various toxic substances, making them less toxic and more suitable for elimination. Other probable in vivo protective effects have also been suggested, including decreased intestinal absorption and increased excretion of toxic substances, prevented gut microbial dysbiosis, increase in the intestinal mucus secretion, decreased production of reactive oxygen species, reduction of inflammation, etc. Having all of this in mind, this review aims to summarize the state-of-the-art knowledge regarding the potential protective effects of different probiotic strains against environmentally relevant toxic substances (mycotoxins, polycyclic aromatic hydrocarbons, pesticides, perfluoroalkyl and polyfluoroalkyl substances, phthalates, bisphenol A and toxic metals)
dc.publisherElsevier Ltd
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//
dc.rightsrestrictedAccess
dc.sourceFood and Chemical Toxicology
dc.subjectProbiotic
dc.subjectBinding
dc.subjectDegradation
dc.subjectEnvironmental chemicals
dc.subjectExposure
dc.subjectMitigation
dc.titleProbiotic cultures as a potential protective strategy against the toxicity of environmentally relevant chemicals: State-of-the-art knowledge
dc.typearticle
dc.rights.licenseARR
dc.citation.volume172
dc.citation.rankM21~
dc.identifier.wos000920597100001
dc.identifier.doi10.1016/j.fct.2022.113582
dc.identifier.pmid36581092
dc.identifier.scopus2-s2.0-85145341027
dc.type.versionpublishedVersion


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