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Photochemical degradation of solid-state nisoldipine monitored by HPLC

Authorized Users Only
2003
Authors
Marinković, Valentina
Agbaba, Danica
Karljiković-Rajić, Katarina
Vladimirov, S
Nedeljković, Jovan M.
Article (Published version)
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Abstract
The photochemical degradation of solid-state nisoldipine, 1,4-dihydropyridine calcium antagonist, was investigated under daylight and UV light conditions. Degradation products were identified by using the retention times of corresponding standards and quantified by high-performance liquid chromatographic method. The daylight illumination induced appearance of nitrosophenylpyridine, while formation of second degradation product, nitrophenylpyridine, was observed only upon UV light illumination. The photodegradation kinetics of solid-state nisoldipine under daylight and UV light illumination belongs to class of zero-order reactions. The rate constants of disappearance of nisoldipine upon illumination were determined for raw material as well as pharmaceuticals (tablets, film-tablets and capsules).
Keywords:
nisoldipine / photochemical degradation / illumination
Source:
Journal of Pharmaceutical and Biomedical Analysis, 2003, 32, 4-5, 929-935
Publisher:
  • Pergamon-Elsevier Science Ltd, Oxford

DOI: 10.1016/S0731-7085(03)00194-8

ISSN: 0731-7085

PubMed: 12899979

WoS: 000184881600034

Scopus: 2-s2.0-0041623025
[ Google Scholar ]
33
32
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/438
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Marinković, Valentina
AU  - Agbaba, Danica
AU  - Karljiković-Rajić, Katarina
AU  - Vladimirov, S
AU  - Nedeljković, Jovan M.
PY  - 2003
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/438
AB  - The photochemical degradation of solid-state nisoldipine, 1,4-dihydropyridine calcium antagonist, was investigated under daylight and UV light conditions. Degradation products were identified by using the retention times of corresponding standards and quantified by high-performance liquid chromatographic method. The daylight illumination induced appearance of nitrosophenylpyridine, while formation of second degradation product, nitrophenylpyridine, was observed only upon UV light illumination. The photodegradation kinetics of solid-state nisoldipine under daylight and UV light illumination belongs to class of zero-order reactions. The rate constants of disappearance of nisoldipine upon illumination were determined for raw material as well as pharmaceuticals (tablets, film-tablets and capsules).
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Photochemical degradation of solid-state nisoldipine monitored by HPLC
VL  - 32
IS  - 4-5
SP  - 929
EP  - 935
DO  - 10.1016/S0731-7085(03)00194-8
ER  - 
@article{
author = "Marinković, Valentina and Agbaba, Danica and Karljiković-Rajić, Katarina and Vladimirov, S and Nedeljković, Jovan M.",
year = "2003",
abstract = "The photochemical degradation of solid-state nisoldipine, 1,4-dihydropyridine calcium antagonist, was investigated under daylight and UV light conditions. Degradation products were identified by using the retention times of corresponding standards and quantified by high-performance liquid chromatographic method. The daylight illumination induced appearance of nitrosophenylpyridine, while formation of second degradation product, nitrophenylpyridine, was observed only upon UV light illumination. The photodegradation kinetics of solid-state nisoldipine under daylight and UV light illumination belongs to class of zero-order reactions. The rate constants of disappearance of nisoldipine upon illumination were determined for raw material as well as pharmaceuticals (tablets, film-tablets and capsules).",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Photochemical degradation of solid-state nisoldipine monitored by HPLC",
volume = "32",
number = "4-5",
pages = "929-935",
doi = "10.1016/S0731-7085(03)00194-8"
}
Marinković, V., Agbaba, D., Karljiković-Rajić, K., Vladimirov, S.,& Nedeljković, J. M.. (2003). Photochemical degradation of solid-state nisoldipine monitored by HPLC. in Journal of Pharmaceutical and Biomedical Analysis
Pergamon-Elsevier Science Ltd, Oxford., 32(4-5), 929-935.
https://doi.org/10.1016/S0731-7085(03)00194-8
Marinković V, Agbaba D, Karljiković-Rajić K, Vladimirov S, Nedeljković JM. Photochemical degradation of solid-state nisoldipine monitored by HPLC. in Journal of Pharmaceutical and Biomedical Analysis. 2003;32(4-5):929-935.
doi:10.1016/S0731-7085(03)00194-8 .
Marinković, Valentina, Agbaba, Danica, Karljiković-Rajić, Katarina, Vladimirov, S, Nedeljković, Jovan M., "Photochemical degradation of solid-state nisoldipine monitored by HPLC" in Journal of Pharmaceutical and Biomedical Analysis, 32, no. 4-5 (2003):929-935,
https://doi.org/10.1016/S0731-7085(03)00194-8 . .

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