The photochemical degradation of solid-state nisoldipine, 1,4-dihydropyridine calcium antagonist, was investigated under daylight and UV light conditions. Degradation products were identified by using the retention times of corresponding standards and quantified by high-performance liquid chromatographic method. The daylight illumination induced appearance of nitrosophenylpyridine, while formation of second degradation product, nitrophenylpyridine, was observed only upon UV light illumination. The photodegradation kinetics of solid-state nisoldipine under daylight and UV light illumination belongs to class of zero-order reactions. The rate constants of disappearance of nisoldipine upon illumination were determined for raw material as well as pharmaceuticals (tablets, film-tablets and capsules).
TY - JOUR
AU - Marinković, Valentina
AU - Agbaba, Danica
AU - Karljiković-Rajić, Katarina
AU - Vladimirov, S
AU - Nedeljković, Jovan M.
PY - 2003
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/438
AB - The photochemical degradation of solid-state nisoldipine, 1,4-dihydropyridine calcium antagonist, was investigated under daylight and UV light conditions. Degradation products were identified by using the retention times of corresponding standards and quantified by high-performance liquid chromatographic method. The daylight illumination induced appearance of nitrosophenylpyridine, while formation of second degradation product, nitrophenylpyridine, was observed only upon UV light illumination. The photodegradation kinetics of solid-state nisoldipine under daylight and UV light illumination belongs to class of zero-order reactions. The rate constants of disappearance of nisoldipine upon illumination were determined for raw material as well as pharmaceuticals (tablets, film-tablets and capsules).
PB - Pergamon-Elsevier Science Ltd, Oxford
T2 - Journal of Pharmaceutical and Biomedical Analysis
T1 - Photochemical degradation of solid-state nisoldipine monitored by HPLC
VL - 32
IS - 4-5
SP - 929
EP - 935
DO - 10.1016/S0731-7085(03)00194-8
ER -
@article{
author = "Marinković, Valentina and Agbaba, Danica and Karljiković-Rajić, Katarina and Vladimirov, S and Nedeljković, Jovan M.",
year = "2003",
abstract = "The photochemical degradation of solid-state nisoldipine, 1,4-dihydropyridine calcium antagonist, was investigated under daylight and UV light conditions. Degradation products were identified by using the retention times of corresponding standards and quantified by high-performance liquid chromatographic method. The daylight illumination induced appearance of nitrosophenylpyridine, while formation of second degradation product, nitrophenylpyridine, was observed only upon UV light illumination. The photodegradation kinetics of solid-state nisoldipine under daylight and UV light illumination belongs to class of zero-order reactions. The rate constants of disappearance of nisoldipine upon illumination were determined for raw material as well as pharmaceuticals (tablets, film-tablets and capsules).",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Photochemical degradation of solid-state nisoldipine monitored by HPLC",
volume = "32",
number = "4-5",
pages = "929-935",
doi = "10.1016/S0731-7085(03)00194-8"
}
Marinković, V., Agbaba, D., Karljiković-Rajić, K., Vladimirov, S.,& Nedeljković, J. M.. (2003). Photochemical degradation of solid-state nisoldipine monitored by HPLC. in Journal of Pharmaceutical and Biomedical Analysis
Pergamon-Elsevier Science Ltd, Oxford., 32(4-5), 929-935.
https://doi.org/10.1016/S0731-7085(03)00194-8
Marinković V, Agbaba D, Karljiković-Rajić K, Vladimirov S, Nedeljković JM. Photochemical degradation of solid-state nisoldipine monitored by HPLC. in Journal of Pharmaceutical and Biomedical Analysis. 2003;32(4-5):929-935.
doi:10.1016/S0731-7085(03)00194-8 .
Marinković, Valentina, Agbaba, Danica, Karljiković-Rajić, Katarina, Vladimirov, S, Nedeljković, Jovan M., "Photochemical degradation of solid-state nisoldipine monitored by HPLC" in Journal of Pharmaceutical and Biomedical Analysis, 32, no. 4-5 (2003):929-935,
https://doi.org/10.1016/S0731-7085(03)00194-8 . .
