Photochemical degradation of solid-state nisoldipine monitored by HPLC
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Nedeljković, Jovan M.
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The photochemical degradation of solid-state nisoldipine, 1,4-dihydropyridine calcium antagonist, was investigated under daylight and UV light conditions. Degradation products were identified by using the retention times of corresponding standards and quantified by high-performance liquid chromatographic method. The daylight illumination induced appearance of nitrosophenylpyridine, while formation of second degradation product, nitrophenylpyridine, was observed only upon UV light illumination. The photodegradation kinetics of solid-state nisoldipine under daylight and UV light illumination belongs to class of zero-order reactions. The rate constants of disappearance of nisoldipine upon illumination were determined for raw material as well as pharmaceuticals (tablets, film-tablets and capsules).
Ključne reči:nisoldipine / photochemical degradation / illumination
Izvor:Journal of Pharmaceutical and Biomedical Analysis, 2003, 32, 4-5, 929-935
- Pergamon-Elsevier Science Ltd, Oxford