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dc.creatorMarinković, Valentina
dc.creatorAgbaba, Danica
dc.creatorKarljiković-Rajić, Katarina
dc.creatorVladimirov, S
dc.creatorNedeljković, Jovan M.
dc.date.accessioned2019-09-02T10:57:06Z
dc.date.available2019-09-02T10:57:06Z
dc.date.issued2003
dc.identifier.issn0731-7085
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/438
dc.description.abstractThe photochemical degradation of solid-state nisoldipine, 1,4-dihydropyridine calcium antagonist, was investigated under daylight and UV light conditions. Degradation products were identified by using the retention times of corresponding standards and quantified by high-performance liquid chromatographic method. The daylight illumination induced appearance of nitrosophenylpyridine, while formation of second degradation product, nitrophenylpyridine, was observed only upon UV light illumination. The photodegradation kinetics of solid-state nisoldipine under daylight and UV light illumination belongs to class of zero-order reactions. The rate constants of disappearance of nisoldipine upon illumination were determined for raw material as well as pharmaceuticals (tablets, film-tablets and capsules).en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.rightsrestrictedAccess
dc.sourceJournal of Pharmaceutical and Biomedical Analysis
dc.subjectnisoldipineen
dc.subjectphotochemical degradationen
dc.subjectilluminationen
dc.titlePhotochemical degradation of solid-state nisoldipine monitored by HPLCen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМаринковић, Валентина; Aгбаба, Даница; Карљиковић-Рајић, Катарина; Недељковић, Јован М.; Владимиров, С;
dc.citation.volume32
dc.citation.issue4-5
dc.citation.spage929
dc.citation.epage935
dc.citation.other32(4-5): 929-935
dc.citation.rankM22
dc.identifier.wos000184881600034
dc.identifier.doi10.1016/S0731-7085(03)00194-8
dc.identifier.pmid12899979
dc.identifier.scopus2-s2.0-0041623025
dc.identifier.rcubconv_1416
dc.type.versionpublishedVersion


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