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Photochemical degradation of solid-state nisoldipine monitored by HPLC
dc.creator | Marinković, Valentina | |
dc.creator | Agbaba, Danica | |
dc.creator | Karljiković-Rajić, Katarina | |
dc.creator | Vladimirov, S | |
dc.creator | Nedeljković, Jovan M. | |
dc.date.accessioned | 2019-09-02T10:57:06Z | |
dc.date.available | 2019-09-02T10:57:06Z | |
dc.date.issued | 2003 | |
dc.identifier.issn | 0731-7085 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/438 | |
dc.description.abstract | The photochemical degradation of solid-state nisoldipine, 1,4-dihydropyridine calcium antagonist, was investigated under daylight and UV light conditions. Degradation products were identified by using the retention times of corresponding standards and quantified by high-performance liquid chromatographic method. The daylight illumination induced appearance of nitrosophenylpyridine, while formation of second degradation product, nitrophenylpyridine, was observed only upon UV light illumination. The photodegradation kinetics of solid-state nisoldipine under daylight and UV light illumination belongs to class of zero-order reactions. The rate constants of disappearance of nisoldipine upon illumination were determined for raw material as well as pharmaceuticals (tablets, film-tablets and capsules). | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.rights | restrictedAccess | |
dc.source | Journal of Pharmaceutical and Biomedical Analysis | |
dc.subject | nisoldipine | en |
dc.subject | photochemical degradation | en |
dc.subject | illumination | en |
dc.title | Photochemical degradation of solid-state nisoldipine monitored by HPLC | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Маринковић, Валентина; Aгбаба, Даница; Карљиковић-Рајић, Катарина; Недељковић, Јован М.; Владимиров, С; | |
dc.citation.volume | 32 | |
dc.citation.issue | 4-5 | |
dc.citation.spage | 929 | |
dc.citation.epage | 935 | |
dc.citation.other | 32(4-5): 929-935 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000184881600034 | |
dc.identifier.doi | 10.1016/S0731-7085(03)00194-8 | |
dc.identifier.pmid | 12899979 | |
dc.identifier.scopus | 2-s2.0-0041623025 | |
dc.type.version | publishedVersion |