Functional thyroid disorders in the pharmacy setting – how can we help our patients?
Funkcionalni poremećaji štitaste žlezde u farmaceutskoj praksi - kako možemo pomoći našim pacijentima?
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Functional thyroid disorders (hypothyroidism and hyperthyroidism) are amongst the most
common endocrine disorders pharmacists encounter on a daily basis. They are highly prevalent
in iodine-replete areas, and affect women about 10 times more often than man. Hypothyroidism
(thyroid hormone deficiency) is usually caused by Hashimoto’s thyroiditis, an autoimmune
disorder that leads to gradual thyroid destruction. The drug-of-choice for treating hypothyroidism
is levothyroxine, a synthetic form of thyroxine. Key points which need to be discussed with
patients who are prescribed levothyroxine for the first time are when/how to administer this drug,
how its effects are monitored, what drugs may affect its efficacy, and the importance of properly
treating hypothyroidism during pregnancy. Hyperthyroidism (increased production of thyroid
hormones) is most often caused by Graves’ disease, another thyroid autoimmune disorder in
which stimulatory autoantibodies against the TSH receptor l...ead to increased thyroid function.
Graves’ disease is most commonly treated with thionamide drugs (thiamazole, carbimazole or
propylthiouracil) and patients using these drugs should be advised on the monitoring
requirements, duration of treatment, and how to recognize possible serious adverse effects
(agranulocytosis and hepatotoxicity), and informed that these drugs must be used during
pregnancy in order to reduce the risk of adverse outcomes for the mother and baby.
Funkcionalni poremećaji štitaste žlezde (hipotiroidizam i hipertiroidizam) spadaju u najčešće endokrine poremećaje sa kojima se farmaceuti svakodnevno susreću. Ovi poremećaji su veoma prevalentni u područjima sa adekvatnim unosom joda i pogađaju žene oko 10 puta češće nego muškarce. Hipotiroidizam (nedostatak tiroidnih hormona) je obično posledica Hašimotovog tiroiditisa, autoimunskog poremećaja koji dovodi do postepene destrukcije štitaste žlezde. Lek izbora za lečenje hipotiroidizma je levotiroksin, sintetski oblik hormona tiroksina. Ključne tačke o kojima treba razgovarati sa pacijentima kojima je prvi put propisan levotiroksin su kada/kako da se primeni ovaj lek, kako se prate njegovi efekti, koji lekovi mogu uticati na njegovu efikasnost i važnost pravilnog lečenja hipotiroidizma tokom trudnoće. Hipertiroidizam (povećana proizvodnja tiroidnih hormona) najčešće je uzrokovan Grejvsovom bolešću, još jednim autoimunskim poremećajem štitaste žlezde, u kojem stimulatorna autoantitela na... TSH receptore dovode do povećane funkcije štitaste žlezde. Grejvsova bolest se najčešće leči tioamidima (tiamazol, karbimazol, propiltiouracil), a pacijenti koji koriste ove lekove treba da budu obavešteni o načinu praćenja efikasnosti, trajanju lečenja, kako da prepoznaju moguće ozbiljne neželjene efekte (agranulocitozu i hepatotoksičnost), kao i da se ovi lekovi moraju koristiti tokom trudnoće kako bi se smanjio rizik od štetnih ishoda za majku i bebu.
Кључне речи:
hypothyroidism / hyperthyroidism / levothyroxine / thionamide drugs / hipotiroidizam / hipertiroidizam / levotiroksin / tioamidiИзвор:
Arhiv za farmaciju, 2022, 72, 5, 503-520Издавач:
- Beograd : Savez farmaceutskih udruženja Srbije
Институција/група
PharmacyTY - JOUR AU - Pecikoza, Uroš PY - 2022 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4399 AB - Functional thyroid disorders (hypothyroidism and hyperthyroidism) are amongst the most common endocrine disorders pharmacists encounter on a daily basis. They are highly prevalent in iodine-replete areas, and affect women about 10 times more often than man. Hypothyroidism (thyroid hormone deficiency) is usually caused by Hashimoto’s thyroiditis, an autoimmune disorder that leads to gradual thyroid destruction. The drug-of-choice for treating hypothyroidism is levothyroxine, a synthetic form of thyroxine. Key points which need to be discussed with patients who are prescribed levothyroxine for the first time are when/how to administer this drug, how its effects are monitored, what drugs may affect its efficacy, and the importance of properly treating hypothyroidism during pregnancy. Hyperthyroidism (increased production of thyroid hormones) is most often caused by Graves’ disease, another thyroid autoimmune disorder in which stimulatory autoantibodies against the TSH receptor lead to increased thyroid function. Graves’ disease is most commonly treated with thionamide drugs (thiamazole, carbimazole or propylthiouracil) and patients using these drugs should be advised on the monitoring requirements, duration of treatment, and how to recognize possible serious adverse effects (agranulocytosis and hepatotoxicity), and informed that these drugs must be used during pregnancy in order to reduce the risk of adverse outcomes for the mother and baby. AB - Funkcionalni poremećaji štitaste žlezde (hipotiroidizam i hipertiroidizam) spadaju u najčešće endokrine poremećaje sa kojima se farmaceuti svakodnevno susreću. Ovi poremećaji su veoma prevalentni u područjima sa adekvatnim unosom joda i pogađaju žene oko 10 puta češće nego muškarce. Hipotiroidizam (nedostatak tiroidnih hormona) je obično posledica Hašimotovog tiroiditisa, autoimunskog poremećaja koji dovodi do postepene destrukcije štitaste žlezde. Lek izbora za lečenje hipotiroidizma je levotiroksin, sintetski oblik hormona tiroksina. Ključne tačke o kojima treba razgovarati sa pacijentima kojima je prvi put propisan levotiroksin su kada/kako da se primeni ovaj lek, kako se prate njegovi efekti, koji lekovi mogu uticati na njegovu efikasnost i važnost pravilnog lečenja hipotiroidizma tokom trudnoće. Hipertiroidizam (povećana proizvodnja tiroidnih hormona) najčešće je uzrokovan Grejvsovom bolešću, još jednim autoimunskim poremećajem štitaste žlezde, u kojem stimulatorna autoantitela na TSH receptore dovode do povećane funkcije štitaste žlezde. Grejvsova bolest se najčešće leči tioamidima (tiamazol, karbimazol, propiltiouracil), a pacijenti koji koriste ove lekove treba da budu obavešteni o načinu praćenja efikasnosti, trajanju lečenja, kako da prepoznaju moguće ozbiljne neželjene efekte (agranulocitozu i hepatotoksičnost), kao i da se ovi lekovi moraju koristiti tokom trudnoće kako bi se smanjio rizik od štetnih ishoda za majku i bebu. PB - Beograd : Savez farmaceutskih udruženja Srbije T2 - Arhiv za farmaciju T1 - Functional thyroid disorders in the pharmacy setting – how can we help our patients? T1 - Funkcionalni poremećaji štitaste žlezde u farmaceutskoj praksi - kako možemo pomoći našim pacijentima? VL - 72 IS - 5 SP - 503 EP - 520 DO - 10.5937/arhfarm72-39858 ER -
@article{ author = "Pecikoza, Uroš", year = "2022", abstract = "Functional thyroid disorders (hypothyroidism and hyperthyroidism) are amongst the most common endocrine disorders pharmacists encounter on a daily basis. They are highly prevalent in iodine-replete areas, and affect women about 10 times more often than man. Hypothyroidism (thyroid hormone deficiency) is usually caused by Hashimoto’s thyroiditis, an autoimmune disorder that leads to gradual thyroid destruction. The drug-of-choice for treating hypothyroidism is levothyroxine, a synthetic form of thyroxine. Key points which need to be discussed with patients who are prescribed levothyroxine for the first time are when/how to administer this drug, how its effects are monitored, what drugs may affect its efficacy, and the importance of properly treating hypothyroidism during pregnancy. Hyperthyroidism (increased production of thyroid hormones) is most often caused by Graves’ disease, another thyroid autoimmune disorder in which stimulatory autoantibodies against the TSH receptor lead to increased thyroid function. Graves’ disease is most commonly treated with thionamide drugs (thiamazole, carbimazole or propylthiouracil) and patients using these drugs should be advised on the monitoring requirements, duration of treatment, and how to recognize possible serious adverse effects (agranulocytosis and hepatotoxicity), and informed that these drugs must be used during pregnancy in order to reduce the risk of adverse outcomes for the mother and baby., Funkcionalni poremećaji štitaste žlezde (hipotiroidizam i hipertiroidizam) spadaju u najčešće endokrine poremećaje sa kojima se farmaceuti svakodnevno susreću. Ovi poremećaji su veoma prevalentni u područjima sa adekvatnim unosom joda i pogađaju žene oko 10 puta češće nego muškarce. Hipotiroidizam (nedostatak tiroidnih hormona) je obično posledica Hašimotovog tiroiditisa, autoimunskog poremećaja koji dovodi do postepene destrukcije štitaste žlezde. Lek izbora za lečenje hipotiroidizma je levotiroksin, sintetski oblik hormona tiroksina. Ključne tačke o kojima treba razgovarati sa pacijentima kojima je prvi put propisan levotiroksin su kada/kako da se primeni ovaj lek, kako se prate njegovi efekti, koji lekovi mogu uticati na njegovu efikasnost i važnost pravilnog lečenja hipotiroidizma tokom trudnoće. Hipertiroidizam (povećana proizvodnja tiroidnih hormona) najčešće je uzrokovan Grejvsovom bolešću, još jednim autoimunskim poremećajem štitaste žlezde, u kojem stimulatorna autoantitela na TSH receptore dovode do povećane funkcije štitaste žlezde. Grejvsova bolest se najčešće leči tioamidima (tiamazol, karbimazol, propiltiouracil), a pacijenti koji koriste ove lekove treba da budu obavešteni o načinu praćenja efikasnosti, trajanju lečenja, kako da prepoznaju moguće ozbiljne neželjene efekte (agranulocitozu i hepatotoksičnost), kao i da se ovi lekovi moraju koristiti tokom trudnoće kako bi se smanjio rizik od štetnih ishoda za majku i bebu.", publisher = "Beograd : Savez farmaceutskih udruženja Srbije", journal = "Arhiv za farmaciju", title = "Functional thyroid disorders in the pharmacy setting – how can we help our patients?, Funkcionalni poremećaji štitaste žlezde u farmaceutskoj praksi - kako možemo pomoći našim pacijentima?", volume = "72", number = "5", pages = "503-520", doi = "10.5937/arhfarm72-39858" }
Pecikoza, U.. (2022). Functional thyroid disorders in the pharmacy setting – how can we help our patients?. in Arhiv za farmaciju Beograd : Savez farmaceutskih udruženja Srbije., 72(5), 503-520. https://doi.org/10.5937/arhfarm72-39858
Pecikoza U. Functional thyroid disorders in the pharmacy setting – how can we help our patients?. in Arhiv za farmaciju. 2022;72(5):503-520. doi:10.5937/arhfarm72-39858 .
Pecikoza, Uroš, "Functional thyroid disorders in the pharmacy setting – how can we help our patients?" in Arhiv za farmaciju, 72, no. 5 (2022):503-520, https://doi.org/10.5937/arhfarm72-39858 . .