Show simple item record

dc.creatorPetrović, Silvana
dc.creatorDobrić, Silva
dc.creatorBokonjić, Dubravko
dc.creatorNiketić, Marjan
dc.creatorGarcia-Pineres, A
dc.creatorMerfort, I
dc.date.accessioned2019-09-02T10:57:15Z
dc.date.available2019-09-02T10:57:15Z
dc.date.issued2003
dc.identifier.issn0378-8741
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/443
dc.description.abstractOral administration of the chloroform extract from Tanacetum larvatum (Griseb. ex Pant.) Kanitz caused a dose-dependent anti-inflammatory effect in the carrageenan-induced rat paw oedema test. The obtained anti-inflammatory effect was 8.6, 32.8, 37.0 and 49.5% for the extract doses of 25, 50, 100 and 200 mg/kg, respectively, being statistically significant at a dose of 50 mg/kg. Indomethacin had a strong anti-inflammatory effect of 73.4% at a dose of 8 mg/kg, but large gastric lesions were detected. When the plant extract in the highest tested dose (200 mg/kg) was concomitantly given with indomethacin, the anti-inflammatory effect was slightly enhanced, but the gastric lesions were significantly reduced. The anti-inflammatory and anti-ulcer activity may be mainly due to the inhibition of DNA binding of the transcription factor NF-kappaB by components of the plant extract. This was proven in an electrophoretic mobility shift assay at a concentration of 50 mug/ml. Due to its anti-inflammatory as well as anti-ulcer effects, Tanacetum larvatum should especially be used combined with those drugs that are known both for their strong anti-inflammatory activities and the ulcerogenic side effects such as NSAIDs.en
dc.publisherElsevier Ireland Ltd, Clare
dc.rightsrestrictedAccess
dc.sourceJournal of Ethnopharmacology
dc.subjectTanacetum larvatum extracten
dc.subjectanti-inflammatoryen
dc.subjectgastric anti-ulceren
dc.subjectNF-kappa Ben
dc.titleEvaluation of Tanacetum larvatum for an anti-inflammatory activity and for the protection against indomethacin-induced ulcerogenesis in ratsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБокоњић, Дубравко; Гарциа-Пинерес, A; Никетић, Марјан; Мерфорт, И; Петровић, Силвана; Добрић, Силва;
dc.citation.volume87
dc.citation.issue1
dc.citation.spage109
dc.citation.epage113
dc.citation.other87(1): 109-113
dc.citation.rankM21
dc.identifier.wos000183590200018
dc.identifier.doi10.1016/S0378-8741(03)00118-1
dc.identifier.pmid12787963
dc.identifier.scopus2-s2.0-0038350856
dc.identifier.rcubconv_1403
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record