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Evaluation of Tanacetum larvatum for an anti-inflammatory activity and for the protection against indomethacin-induced ulcerogenesis in rats
dc.creator | Petrović, Silvana | |
dc.creator | Dobrić, Silva | |
dc.creator | Bokonjić, Dubravko | |
dc.creator | Niketić, Marjan | |
dc.creator | Garcia-Pineres, A | |
dc.creator | Merfort, I | |
dc.date.accessioned | 2019-09-02T10:57:15Z | |
dc.date.available | 2019-09-02T10:57:15Z | |
dc.date.issued | 2003 | |
dc.identifier.issn | 0378-8741 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/443 | |
dc.description.abstract | Oral administration of the chloroform extract from Tanacetum larvatum (Griseb. ex Pant.) Kanitz caused a dose-dependent anti-inflammatory effect in the carrageenan-induced rat paw oedema test. The obtained anti-inflammatory effect was 8.6, 32.8, 37.0 and 49.5% for the extract doses of 25, 50, 100 and 200 mg/kg, respectively, being statistically significant at a dose of 50 mg/kg. Indomethacin had a strong anti-inflammatory effect of 73.4% at a dose of 8 mg/kg, but large gastric lesions were detected. When the plant extract in the highest tested dose (200 mg/kg) was concomitantly given with indomethacin, the anti-inflammatory effect was slightly enhanced, but the gastric lesions were significantly reduced. The anti-inflammatory and anti-ulcer activity may be mainly due to the inhibition of DNA binding of the transcription factor NF-kappaB by components of the plant extract. This was proven in an electrophoretic mobility shift assay at a concentration of 50 mug/ml. Due to its anti-inflammatory as well as anti-ulcer effects, Tanacetum larvatum should especially be used combined with those drugs that are known both for their strong anti-inflammatory activities and the ulcerogenic side effects such as NSAIDs. | en |
dc.publisher | Elsevier Ireland Ltd, Clare | |
dc.rights | restrictedAccess | |
dc.source | Journal of Ethnopharmacology | |
dc.subject | Tanacetum larvatum extract | en |
dc.subject | anti-inflammatory | en |
dc.subject | gastric anti-ulcer | en |
dc.subject | NF-kappa B | en |
dc.title | Evaluation of Tanacetum larvatum for an anti-inflammatory activity and for the protection against indomethacin-induced ulcerogenesis in rats | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Бокоњић, Дубравко; Гарциа-Пинерес, A; Никетић, Марјан; Мерфорт, И; Петровић, Силвана; Добрић, Силва; | |
dc.citation.volume | 87 | |
dc.citation.issue | 1 | |
dc.citation.spage | 109 | |
dc.citation.epage | 113 | |
dc.citation.other | 87(1): 109-113 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000183590200018 | |
dc.identifier.doi | 10.1016/S0378-8741(03)00118-1 | |
dc.identifier.pmid | 12787963 | |
dc.identifier.scopus | 2-s2.0-0038350856 | |
dc.type.version | publishedVersion |